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Angiotensin converting enzyme and sodium glucose cotransporter inhibitors alleviate inflammatory effects of SARS-CoV-2 in cardiomyocytes
, 1, 1, 2, 3, 3, 3, 3, 2, 2, 1
Affiliations- Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
- Infectious Disease Division, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
open access
Abstract
Abstract
About this articleTitle
Angiotensin converting enzyme and sodium glucose cotransporter inhibitors alleviate inflammatory effects of SARS-CoV-2 in cardiomyocytes
Journal
Issue
Article type
Research Letter
Pages
702-706
Published online
2022-05-13
Page views
4250
Article views/downloads
467
DOI
10.5603/CJ.a2022.0033
Pubmed
Bibliographic record
Cardiol J 2022;29(4):702-706.
Authors
Chun-Ka Wong
Yee-Man Lau
Wing-Hon Lai
Ricky-Ruiqi Zhang
Hayes Kam-Hei Luk
Antonio Cheuk-Pui Wong
Patrick Chiu-Yat Woo
Susanna Kar-Pui Lau
Kwok-Hung Chan
Ivan Fan-Ngai Hung
Chung-Wah Siu
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- Wang L, Zhang YL, Lin QY, et al. CXCL1-CXCR2 axis mediates angiotensin II-induced cardiac hypertrophy and remodelling through regulation of monocyte infiltration. Eur Heart J. 2018; 39(20): 1818–1831.
- Bean DM, Kraljevic Z, Searle T, et al. Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers are not associated with severe COVID-19 infection in a multi-site UK acute hospital trust. Eur J Heart Fail. 2020; 22(6): 967–974.
- Németh ZH, Deitch EA, Lu Qi, et al. NHE blockade inhibits chemokine production and NF-kappaB activation in immunostimulated endothelial cells. Am J Physiol Cell Physiol. 2002; 283(2): C396–C403.
- Uthman L, Baartscheer A, Bleijlevens B, et al. Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na/H exchanger, lowering of cytosolic Na and vasodilation. Diabetologia. 2018; 61(3): 722–726.
