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Elevated resting heart rate as independent in-hospital prognostic marker in COVID-19
Affiliations- Clinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy
- Divisione di Medicina, Ospedale Bassini, Cinisello Balsamo, Milan, Italy
- Unità Operativa Complessa di Cardiologia, Magenta Hospital, Magenta, Milan, Italy
open access
Abstract
Background: Scarce and non-homogeneous data are available on the prognostic value of clinic heart rate (HR) in coronavirus disease 2019 (COVID-19).
Methods: The present study evaluated in 389 patients hospitalized for COVID-19 the in-hospital prognostic value of resting HR, assessed over different time periods, i.e., at hospital admission, during initial 3 days and 7 days of hospitalization.
Results: Results show that assessment of this hemodynamic variable during hospitalization provides information on the clinical outcome of the patients, greater HR values being associated with a worse inhospital prognosis. The prognostic value of elevated HR during COVID-19: 1) was independent on other confounders such as age, gender, comorbidities and fever, 2) appeared to be strengthened by repeated measurements of HR during the initial 3/7 days of hospitalization, and 3) was detectable in patients in which the therapeutic intervention did not include drugs, such as beta-blockers, calcium antagonists, digoxin, ivabradine and antiarrhythmic compounds known to interfere with HR.
Conclusions: Heart rate may represent an important marker of a patient’s outcome in COVID-19.
Abstract
Background: Scarce and non-homogeneous data are available on the prognostic value of clinic heart rate (HR) in coronavirus disease 2019 (COVID-19).
Methods: The present study evaluated in 389 patients hospitalized for COVID-19 the in-hospital prognostic value of resting HR, assessed over different time periods, i.e., at hospital admission, during initial 3 days and 7 days of hospitalization.
Results: Results show that assessment of this hemodynamic variable during hospitalization provides information on the clinical outcome of the patients, greater HR values being associated with a worse inhospital prognosis. The prognostic value of elevated HR during COVID-19: 1) was independent on other confounders such as age, gender, comorbidities and fever, 2) appeared to be strengthened by repeated measurements of HR during the initial 3/7 days of hospitalization, and 3) was detectable in patients in which the therapeutic intervention did not include drugs, such as beta-blockers, calcium antagonists, digoxin, ivabradine and antiarrhythmic compounds known to interfere with HR.
Conclusions: Heart rate may represent an important marker of a patient’s outcome in COVID-19.
Keywords
coronavirus disease 2019 (COVID-19), heart rate, sympathetic nervous system, prognosis
About this articleTitle
Elevated resting heart rate as independent in-hospital prognostic marker in COVID-19
Journal
Issue
Article type
Original Article
Pages
181-187
Published online
2022-02-18
Page views
5178
Article views/downloads
801
DOI
Pubmed
Bibliographic record
Cardiol J 2022;29(2):181-187.
Keywords
coronavirus disease 2019 (COVID-19)
heart rate
sympathetic nervous system
prognosis
Authors
Jennifer Vanoli
Giacomo Marro
Raffaella Dell'Oro
Rita Facchetti
Fosca Quarti-Trevano
Domenico Spaziani
Guido Grassi
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