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open access

Vol 29, No 4 (2022)
Review Article
Submitted: 2021-07-29
Accepted: 2022-05-14
Published online: 2022-05-30
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Heart failure with preserved ejection fraction update: A review of clinical trials and new therapeutic considerations

Andrii Maryniak1, Nodari Maisuradze1, Rafsan Ahmed1, Patrick Biskupski2, Joseph Jayaraj1, Adam S. Budzikowski3
DOI: 10.5603/CJ.a2022.0051
·
Pubmed: 35762077
·
Cardiol J 2022;29(4):670-679.
Affiliations
  1. Department of Medicine, State University of New York: Downstate Medical Center, Brooklyn, NY, United States
  2. Department of Medicine, Lincoln Medical Center, Bronx, NY, United States
  3. Division of Cardiology, Department of Medicine, State University of New York: Downstate Medical Center, Brooklyn, NY, United States

open access

Vol 29, No 4 (2022)
Review articles — Clinical cardiology
Submitted: 2021-07-29
Accepted: 2022-05-14
Published online: 2022-05-30

Abstract

Between 2013 and 2016 there were approximately 6.2 million adults in the United States living with heart failure; nearly half had an ejection fraction that was preserved. Despite the high prevalence of heart failure with preserved ejection fraction (HFpEF), our understanding of this disease is limited and it still carries significant morbidity and mortality worldwide. At present, physicians are burdened by the inconclusive benefits of currently available treatment options. Recently the scientific community has seen an influx of new pathophysiology studies and outcome trials that have reshaped our understanding of HFpEF as a complex, multi-systemic disease. Pharmacological trials involving beta-blockers, angiotensin II receptor antagonists, aldosterone antagonists, and angiotensin-neprilysin inhibitors have demonstrated encouraging results, but have yet to reach the significance of advancements made in the treatment of heart failure with reduced ejection fraction. This review aims to summarize landmark clinical trials that have influenced current treatment guidelines, and reports on emerging evidence supporting/refuting new treatment modalities including pharmacotherapy, lifestyle modification and device therapy.

Abstract

Between 2013 and 2016 there were approximately 6.2 million adults in the United States living with heart failure; nearly half had an ejection fraction that was preserved. Despite the high prevalence of heart failure with preserved ejection fraction (HFpEF), our understanding of this disease is limited and it still carries significant morbidity and mortality worldwide. At present, physicians are burdened by the inconclusive benefits of currently available treatment options. Recently the scientific community has seen an influx of new pathophysiology studies and outcome trials that have reshaped our understanding of HFpEF as a complex, multi-systemic disease. Pharmacological trials involving beta-blockers, angiotensin II receptor antagonists, aldosterone antagonists, and angiotensin-neprilysin inhibitors have demonstrated encouraging results, but have yet to reach the significance of advancements made in the treatment of heart failure with reduced ejection fraction. This review aims to summarize landmark clinical trials that have influenced current treatment guidelines, and reports on emerging evidence supporting/refuting new treatment modalities including pharmacotherapy, lifestyle modification and device therapy.

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Keywords

heart failure, heart failure with preserved ejection fraction, HFpEF, diastolic heart failure, clinical trials

About this article
Title

Heart failure with preserved ejection fraction update: A review of clinical trials and new therapeutic considerations

Journal

Cardiology Journal

Issue

Vol 29, No 4 (2022)

Article type

Review Article

Pages

670-679

Published online

2022-05-30

Page views

5805

Article views/downloads

1647

DOI

10.5603/CJ.a2022.0051

Pubmed

35762077

Bibliographic record

Cardiol J 2022;29(4):670-679.

Keywords

heart failure
heart failure with preserved ejection fraction
HFpEF
diastolic heart failure
clinical trials

Authors

Andrii Maryniak
Nodari Maisuradze
Rafsan Ahmed
Patrick Biskupski
Joseph Jayaraj
Adam S. Budzikowski

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