open access
New scoring system for predicting percutaneous coronary intervention of chronic total occlusion success: Impact of operator’s experience


- Interventional Cardiology Unit, Cardiology Division, Joan XXIII University Hospital, Pere Virgili Health Research Institute (IISPV), Tarragona, Spain
- Cardiology Division, Joan XXIII Univer sity Hospital, Pere Virgili Health Research Insitute (IISPV), Tarragona, Spain
open access
Abstract
Background: Several scoring systems have been developed in order to predict percutaneous coronary intervention (PCI) result of chronic total occlusion (CTO). The scores principally include anatomic and clinical variables. Operator experience is a decisive factor for achieving successful result. We sought to assess the real impact of operator growing experience on CTO-PCI success.
Methods: The angiographic and clinical variables of CTO-PCIs performed in our center between May 2007 and April 2021 were collected, and variables with potential association with procedural result were thoroughly reviewed. The influence of operator experience based on the number of previous CTO-PCIs was statistically assessed. A scoring system with combination of anatomic variables and operator experience was devised.
Results: A total of 540 PCIs in 457 patients were performed in our institution. The scoring model was developed from the derivation set (2/3 of the cohort). The final variables in logistic regression model were CTO length ≥ 20 mm, blunt stump, vessel tortuosity > 45o and operator experience < 100 PCIs. The model showed good performance in the derivation set (area under curve [AUC]: 0.768; confidence interval [CI]: 0706–0.830; p < 0.001) with no significant shrinkage in the validation set (AUC: 0.704; CI: 0.613–0.796; p < 0.001).
Conclusions: This new score (E-CTO score) adequately predict the probability of CTO-PCI failure. The model includes a variable representing operator experience along with other anatomic variables.
Abstract
Background: Several scoring systems have been developed in order to predict percutaneous coronary intervention (PCI) result of chronic total occlusion (CTO). The scores principally include anatomic and clinical variables. Operator experience is a decisive factor for achieving successful result. We sought to assess the real impact of operator growing experience on CTO-PCI success.
Methods: The angiographic and clinical variables of CTO-PCIs performed in our center between May 2007 and April 2021 were collected, and variables with potential association with procedural result were thoroughly reviewed. The influence of operator experience based on the number of previous CTO-PCIs was statistically assessed. A scoring system with combination of anatomic variables and operator experience was devised.
Results: A total of 540 PCIs in 457 patients were performed in our institution. The scoring model was developed from the derivation set (2/3 of the cohort). The final variables in logistic regression model were CTO length ≥ 20 mm, blunt stump, vessel tortuosity > 45o and operator experience < 100 PCIs. The model showed good performance in the derivation set (area under curve [AUC]: 0.768; confidence interval [CI]: 0706–0.830; p < 0.001) with no significant shrinkage in the validation set (AUC: 0.704; CI: 0.613–0.796; p < 0.001).
Conclusions: This new score (E-CTO score) adequately predict the probability of CTO-PCI failure. The model includes a variable representing operator experience along with other anatomic variables.
Keywords
percutaneous coronary intervention, coronary occlusions, coronary arteries


Title
New scoring system for predicting percutaneous coronary intervention of chronic total occlusion success: Impact of operator’s experience
Journal
Issue
Article type
Original Article
Pages
506-515
Published online
2021-09-23
Page views
1719
Article views/downloads
629
DOI
Pubmed
Bibliographic record
Cardiol J 2023;30(4):506-515.
Keywords
percutaneous coronary intervention
coronary occlusions
coronary arteries
Authors
Mohsen Mohandes
Cristina Moreno
Mónica Fuertes
Sergio Rojas
Alberto Pernigotti
Diego Zambrano
Victor Doblas
Francisco Fernández
Jordi Guarinos
Alfredo Bardají


- Brilakis E, Banerjee S, Karmpaliotis D, et al. Procedural outcomes of chronic total occlusion percutaneous coronary intervention. JACC: Cardiovascular Interventions. 2015; 8(2): 245–253.
- Azzalini L, Carlino M, Bellini B, et al. Long-Term outcomes of chronic total occlusion recanalization versus percutaneous coronary intervention for complex non-occlusive coronary artery disease. Am J Cardiol. 2020; 125(2): 182–188.
- Morino Y, Abe M, Morimoto T, et al. Predicting successful guidewire crossing through chronic total occlusion of native coronary lesions within 30 minutes. JACC: Cardiovascular Interventions. 2011; 4(2): 213–221.
- Christopoulos G, Kandzari DE, Yeh RW, et al. Development and Validation of a Novel Scoring System for Predicting Technical Success of Chronic Total Occlusion Percutaneous Coronary Interventions: The PROGRESS CTO (Prospective Global Registry for the Study of Chronic Total Occlusion Intervention) Score. JACC Cardiovasc Interv. 2016; 9(1): 1–9.
- De Jin C, Kim MH, Kim SJ, et al. Predicting successful recanalization in patients with native coronary chronic total occlusion: the busan CTO score. Cardiology. 2017; 137(2): 83–91.
- Guelker JE, Bansemir L, Ott R, et al. Validity of the J-CTO Score and the CL-Score for predicting successful CTO recanalization. Int J Cardiol. 2017; 230: 228–231.
- Christopoulos G, Wyman RM, Alaswad K, et al. Clinical utility of the japan-chronic total occlusion score in coronary chronic total occlusion interventions: results from a multicenter registry. Circ Cardiovasc Interv. 2015; 8(7): e002171.
- Ybarra LF, Rinfret S, Brilakis ES, et al. Definitions and clinical trial design principles for coronary artery chronic total occlusion therapies: CTO-ARC consensus recommendations. Circulation. 2021; 143(5): 479–500.
- Morino Y, Abe M, Morimoto T. Predicting Successful Guidewire Crossing Through Chronic Total Occlusion of Native Coronary Lesions Within 30 Minutes The J-CTO (Multicenter CTO Registry in Japan) Score as a Difficulty Grading and Time Assessment Tool. JACC Cardiovasc Interv. 2011; 4(2): 213–221.
- Sumitsuji S, Inoue K, Ochiai M, et al. Fundamental wire technique and current standard strategy of percutaneous intervention for chronic total occlusion with histopathological insights. JACC Cardiovasc Interv. 2011; 4(9): 941–951.
- Thygesen K, Alpert J, Jaffe A, et al. Fourth universal definition of myocardial infarction (2018). Eur Heart J. 2018; 40(3): 237–269.
- Alessandrino G, Chevalier B, Lefèvre T, et al. A clinical and angiographic scoring system to predict the probability of successful first-attempt percutaneous coronary intervention in patients with total chronic coronary occlusion. JACC Cardiovasc Interv. 2015; 8(12): 1540–1548.
- Szijgyarto Z, Rampat R, Werner GS, et al. Derivation and Validation of a Chronic Total Coronary Occlusion Intervention Procedural Success Score From the 20,000-Patient EuroCTO Registry: The EuroCTO (CASTLE) Score. JACC Cardiovasc Interv. 2019; 12(4): 335–342.
- Mohandes M, Guarinos J, Rodríguez J, et al. [Negative angiographic markers in percutaneous coronary intervention of chronic total occlusions]. Arch Cardiol Mex. 2018; 88(2): 93–99.
- Harding SA, Wu EB, Lo S, et al. A new algorithm for crossing chronic total occlusions from the asia pacific chronic total occlusion club. JACC Cardiovasc Interv. 2017; 10(21): 2135–2143.
- Galassi AR, Werner GS, Boukhris M, et al. Percutaneous recanalisation of chronic total occlusions: 2019 consensus document from the EuroCTO Club. EuroIntervention. 2019; 15(2): 198–208.
- Zein R, Seth M, Othman H, et al. Association of operator and hospital experience with procedural success rates and outcomes in patients undergoing percutaneous coronary interventions for chronic total occlusions: insights from the blue cross blue shield of Michigan cardiovascular consortium. Circ Cardiovasc Interv. 2020; 13(8): e008863.
- Suzuki Y, Tsuchikane E, Katoh O, et al. Outcomes of percutaneous coronary interventions for chronic total occlusion performed by highly experienced japanese specialists: the first report from the japanese CTO-PCI expert registry. JACC Cardiovasc Interv. 2017; 10(21): 2144–2154.
- Habara M, Tsuchikane E, Muramatsu T, et al. Comparison of percutaneous coronary intervention for chronic total occlusion outcome according to operator experience from the Japanese retrograde summit registry. Catheter Cardiovasc Interv. 2016; 87(6): 1027–1035.
- Mohandes M, Moreno C, Rojas S, et al. J-chronic total occlusion score predictive capacity for percutaneous coronary intervention success of chronic total occlusion: Results from a European single center cohort with progressive experience over time. Cardiol J. 2021 [Epub ahead of print].
- Whitlow PL, Burke MN, Lombardi WL, et al. Use of a novel crossing and re-entry system in coronary chronic total occlusions that have failed standard crossing techniques: results of the FAST-CTOs (Facilitated Antegrade Steering Technique in Chronic Total Occlusions) trial. JACC Cardiovasc Interv. 2012; 5(4): 393–401.
- Christopoulos G, Menon R, Karmpaliotis D, et al. Application of the “hybrid approach” to chronic total occlusions in a contemporary multicenter us registry. J Am Coll Cardiol. 2015; 65(10): A1796.