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Influence of METHoxyflurane on ANtiplatelet Effect of ticagrelor in patients with unstable angina pectoris: Rationale and a protocol of a randomized clinical METHANE-SIRIO 4 study
, 1, 1, 2, 1, 3, 4, 5, 6, 78, 1, 2, 1
Affiliations- Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
- Department of Health Promotion, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
- Medical University of Silesia, Katowice, Poland
- University and Clinical Hospital of Wroclaw, Poland
- National Heart and Lung Institute, Imperial College London, United Kingdom
- Department of Clinical Pharmacology, Medical University of Vienna, Austria
- Medical University of Bialystok, Poland
- Higher School of Strategic Planning, Dabrowa Gornicza, Poland
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Abstract
Abstract
About this articleTitle
Influence of METHoxyflurane on ANtiplatelet Effect of ticagrelor in patients with unstable angina pectoris: Rationale and a protocol of a randomized clinical METHANE-SIRIO 4 study
Journal
Issue
Article type
Study Protocol
Pages
324-328
Published online
2021-10-08
Page views
5262
Article views/downloads
829
DOI
Pubmed
Bibliographic record
Cardiol J 2022;29(2):324-328.
Authors
Piotr Niezgoda
Malwina Barańska
Piotr Adamski
Łukasz Pietrzykowski
Michał Piotr Marszałł
Wojciech Wojakowski
Wiktor Kuliczkowski
Diana Gorog
Bernd Jilma
Klaudiusz Nadolny
Eliano Pio Navarese
Aldona Kubica
Jacek Kubica
References (18)- Kubica J, Adamski P, Ostrowska M, et al. Morphine delays and attenuates ticagrelor exposure and action in patients with myocardial infarction: the randomized, double-blind, placebo-controlled IMPRESSION trial. Eur Heart J. 2015; 37(3): 245–252.
- Hobl EL, Reiter B, Schoergenhofer C, et al. Morphine decreases ticagrelor concentrations but not its antiplatelet effects: a randomized trial in healthy volunteers. Eur J Clin Invest. 2016; 46(1): 7–14.
- Parodi G, Bellandi B, Xanthopoulou I, et al. Morphine is associated with a delayed activity of oral antiplatelet agents in patients with ST-elevation acute myocardial infarction undergoing primary percutaneous coronary intervention. Circ Cardiovasc Interv. 2015; 8(1).
- Hobl EL, Stimpfl T, Ebner J, et al. Morphine decreases clopidogrel concentrations and effects: a randomized, double-blind, placebo-controlled trial. J Am Coll Cardiol. 2014; 63(7): 630–635.
- Hobl EL, Reiter B, Schoergenhofer C, et al. Morphine interaction with prasugrel: a double-blind, cross-over trial in healthy volunteers. Clin Res Cardiol. 2016; 105(4): 349–355.
- Umińska JM, Ratajczak J, Buszko K, et al. Impact of mild therapeutic hypothermia on bioavailability of ticagrelor in patients with acute myocardial infarction after out-of-hospital cardiac arrest. Cardiol J. 2020; 27(6): 780–788.
- Ibanez B, James S, Agewall S, et al. et al.. ESC Scientific Document Group. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018; 39(2): 119–177.
- Ostrowska M, Gorog D. Does morphine remain a standard of care in acute myocardial infarction? Med Res J. 2020; 5(1): 46–49.
- Kubica J, Adamski P, Paciorek P, et al. Treatment of patients with acute coronary syndrome: Recommendations for medical emergency teams: Focus on antiplatelet therapies. Updated experts' standpoint. Cardiol J. 2018; 25(3): 291–300.
- Nadolny K, Ładny JR, Gałązkowski R, et al. Medical emergency team interventions in patients with ST-segment elevation myocardial infarction in Poland in 2018. Kardiol Pol. 2020; 78(4): 292–299.
- Kubica J, Kubica A, Jilma B, et al. Impact of morphine on antiplatelet effects of oral P2Y12 receptor inhibitors. Int J Cardiol. 2016; 215: 201–208.
- Zhang K, Yang W, Zhang M, et al. Pretreatment with antiplatelet drugs improves the cardiac function after myocardial infarction without reperfusion in a mouse model. Cardiol J. 2021; 28(1): 118–128.
- Niezgoda P, Sikora J, Barańska M, et al. Crushed sublingual versus oral ticagrelor administration strategies in patients with unstable angina. A pharmacokinetic/pharmacodynamic study. Thromb Haemost. 2017; 117(4): 718–726.
- Zafar MU, Farkouh ME, Fuster V, et al. Crushed clopidogrel administered via nasogastric tube has faster and greater absorption than oral whole tablets. J Interv Cardiol. 2009; 22(4): 385–389.
- Parodi G, Xanthopoulou I, Bellandi B, et al. Ticagrelor crushed tablets administration in STEMI patients: the MOJITO study. J Am Coll Cardiol. 2015; 65(5): 511–512.
- Sikora J, Niezgoda P, Barańska M, et al. METoclopramide Administration as a Strategy to Overcome MORPHine-ticagrelOr Interaction in PatientS with Unstable Angina PectorIS-The METAMORPHOSIS Trial. Thromb Haemost. 2018; 118(12): 2126–2133.
- Niezgoda P, Barańska MA, Sikora J, et al. Oral NAloxone to overcome the moRphine effect in acute COronary syndrome patients treated with TICagrelor - NARCOTIC trial. Cardiol J. 2020 [Epub ahead of print].
- Ibrahim K, Shah R, Goli RR, et al. Fentanyl Delays the Platelet Inhibition Effects of Oral Ticagrelor: Full Report of the PACIFY Randomized Clinical Trial. Thromb Haemost. 2018; 118(8): 1409–1418.
