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A systematic review of nonsynonymous single nucleotide polymorphisms in the renin–angiotensin–aldosterone system
, 1
Affiliations- 1st Department and Chair of Car diology, Medical University of Lodz, Poland
open access
Abstract
In this recent publication review the authors aimed to collect evidence of impact of nonsynonymous single nucleotide polymorphisms (nsSNP) in the renin–angiotensin–aldosterone system on patients’ phenotype not only regarding arterial hypertension and its complications, but also the impact on other diseases of interest outside the field of cardiovascular medicine.
PubMed database records published between 2017–2020 were searched and all positive case-control studies or positive studies with human DNA were selected.
The search identified 104 articles, of which 22 were included on the basis of the inclusion criteria. This paper presents the impact of 44 nsSNPs in panels for genes of renin, angiotensinogen, angiotensin-converting enzyme, angiotensin receptor and aldosterone on the clinical picture of investigated cohorts or on the peptide-protein interactions as consequence of nsSNPs.
Genetic variability in nsSNPs of the RAAS is involved in the pathogenesis of arterial hypertension and its complications, and surprisingly also in the pathogenesis of conditions not associated with elevated blood pressure, like neoplasms or inflammatory diseases.
Abstract
In this recent publication review the authors aimed to collect evidence of impact of nonsynonymous single nucleotide polymorphisms (nsSNP) in the renin–angiotensin–aldosterone system on patients’ phenotype not only regarding arterial hypertension and its complications, but also the impact on other diseases of interest outside the field of cardiovascular medicine.
PubMed database records published between 2017–2020 were searched and all positive case-control studies or positive studies with human DNA were selected.
The search identified 104 articles, of which 22 were included on the basis of the inclusion criteria. This paper presents the impact of 44 nsSNPs in panels for genes of renin, angiotensinogen, angiotensin-converting enzyme, angiotensin receptor and aldosterone on the clinical picture of investigated cohorts or on the peptide-protein interactions as consequence of nsSNPs.
Genetic variability in nsSNPs of the RAAS is involved in the pathogenesis of arterial hypertension and its complications, and surprisingly also in the pathogenesis of conditions not associated with elevated blood pressure, like neoplasms or inflammatory diseases.
Keywords
nonsynonymous single nucleotide polymorphisms, renin–angiotensin–aldosterone system
About this articleTitle
A systematic review of nonsynonymous single nucleotide polymorphisms in the renin–angiotensin–aldosterone system
Journal
Issue
Article type
Review Article
Pages
1020-1027
Published online
2021-05-28
Page views
5405
Article views/downloads
1267
DOI
Pubmed
Bibliographic record
Cardiol J 2022;29(6):1020-1027.
Keywords
nonsynonymous single nucleotide polymorphisms
renin–angiotensin–aldosterone system
Authors
Tomasz Rechciński
Jarosław D. Kasprzak
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