open access
ISCHEMIA trial: The long-awaited evidence to confirm our prejudices


- San Pedro Hospital, Logroño, Spain
- Department of Cardiology, Bristol Heart Instittute, Bristol, United Kingdom
- Cardiology Practice, München, Germany
- Cardiology Department, Andrzej Frycz-Modrzewski Kraków University, American Heart of Poland, Bielsko Biała, Poland
- Marienhospital, Aachen, Germany
- Jilin Heart Hospital, Changchun, China
- Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
- Department of Cardiology, IIS-Hospital Universitario Fundación Jiménez Díaz — Quironsalud, Madrid, Spain
- Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain
- Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
- Leopoldina hospital Schweinfurt, Gustav- Adolf- Str. 8, Germany
- 1st Department of Cardiology Medical University of Gdansk, Poland
- Cardio Care Heart Centre, Ventura del Mar 11, 29660 Marbella, Spain
open access
Abstract
Abstract


Title
ISCHEMIA trial: The long-awaited evidence to confirm our prejudices
Journal
Issue
Article type
Editorial
Pages
336-341
Published online
2020-09-10
Page views
1029
Article views/downloads
1334
DOI
10.5603/CJ.2020.0109
Pubmed
Bibliographic record
Cardiol J 2020;27(4):336-341.
Authors
Carlos Cortés
Thomas W. Johnson
Sigmund Silber
Piotr P. Buszman
Tudor C. Poerner
Francesco Lavarra
Borja Ibáñez
Yongcheol Kim
Karl Mischke
Miłosz Jaguszewski
Juan Luis Gutiérrez-Chico


- Maron D, Hochman J, Reynolds H, et al. Initial Invasive or Conservative Strategy for Stable Coronary Disease. N Engl J Med. 2020; 382(15): 1395–1407.
- Knuuti J, Wijns W, Saraste A, et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J. 2020; 41: 407–477.
- Machiavelli, Niccolò, 1469-1527. The prince. Reprinted with revisions 1984. Harmondsworth, Eng.; New York, NY: Penguin Books; 1981.Available at: https://search.library.wisc.edu/catalog/999715970702121.
- Maron DJ, Hochman JS, O'Brien SM, et al. ISCHEMIA Trial Research Group. International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial: Rationale and design. Am Heart J. 2018; 201: 124–135.
- Hochman JS, Reynolds HR, Bangalore S, et al. ISCHEMIA Research Group. Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial. JAMA Cardiol. 2019; 4(3): 273–286.
- Spertus JA, Jones PG, Maron DJ, et al. ISCHEMIA Research Group. Health-Status Outcomes with Invasive or Conservative Care in Coronary Disease. N Engl J Med. 2020; 382(15): 1408–1419.
- Gutiérrez-Chico JL, Louvard Y. DECISION-CTO: A "negative" clinical trial? Really? Cardiol J. 2017; 24(3): 231–233.
- Bangalore S, Maron D, Stone G, et al. Routine revascularization versus initial medical therapy for stable ischemic heart disease: a systematic review and meta-analysis of randomized trials. Circulation. 2020.
- Werner GS, Martin-Yuste V, Hildick-Smith D, et al. EUROCTO trial investigators. A randomized multicentre trial to compare revascularization with optimal medical therapy for the treatment of chronic total coronary occlusions. Eur Heart J. 2018; 39(26): 2484–2493.
- Lee SW, Lee PH, Ahn JM, et al. Randomized trial evaluating percutaneous coronary intervention for the treatment of chronic total occlusion. Circulation. 2019; 139(14): 1674–1683.
- Toth GG, Toth B, Johnson NP, et al. Revascularization decisions in patients with stable angina and intermediate lesions: results of the international survey on interventional strategy. Circ Cardiovasc Interv. 2014; 7(6): 751–759.
- Tonino PAL, De Bruyne B, Pijls NHJ, et al. FAME Study Investigators. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med. 2009; 360(3): 213–224.
- Neumann F-J, Sousa-Uva M, Ahlsson A, et al. 2018 ESC/EACTS Guidelines on myocardial revascularization. Eur Heart J. 2019; 40: 87–165.
- De Bruyne B, Pijls NHJ, Kalesan B, et al. FAME 2 Trial Investigators. Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease. N Engl J Med. 2012; 367(11): 991–1001.
- Jaguszewski M, Zabalza Cerdeiriña M, Alushi B, et al. How should I treat recurrent chest pain and systolic dysfunction after chemotherapy with anthracyclines? EuroIntervention. 2017; 12(13): 1674–1677.
- Gutiérrez-Chico JL, Zhao S, Chatzizisis YS. Vorticity: At the crossroads of coronary biomechanics and physiology. Atherosclerosis. 2018; 273: 115–116.
- Boden WE, O’Rourke RA, Teo KK, et al. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med. 2007; 356: 1503–1516.
- Härle T, Zeymer U, Hochadel M, et al. Real-world use of fractional flow reserve in Germany: results of the prospective ALKK coronary angiography and PCI registry. Clin Res Cardiol. 2017; 106(2): 140–150.
- Lee HS, Lee JM, Nam CW, et al. Consensus document for invasive coronary physiologic assessment in Asia-Pacific countries. Cardiol J. 2019; 26(3): 215–225.
- Sleight P. Debate: Subgroup analyses in clinical trials: fun to look at - but don’t believe them! Curr Control Trials Cardiovasc Med. 2000; 1(1): 25–27.
- Figulla HR, Lauten A, Maier LS, et al. Percutaneous Coronary Intervention in Stable Coronary Heart Disease -Is Less More? Dtsch Arztebl Int. 2020; 117(9): 137–144.
- Gutiérrez-Chico JL, Chen Y, Yu W, et al. Diagnostic accuracy and reproducibility of optical flow ratio for functional evaluation of coronary stenosis in a prospective series. Cardiol J. 2020 [Epub ahead of print].