open access

Vol 27, No 4 (2020)
Submitted: 2020-07-28
Accepted: 2020-07-29
Published online: 2020-09-10
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ISCHEMIA trial: The long-awaited evidence to confirm our prejudices

Carlos Cortés1, Thomas W. Johnson2, Sigmund Silber3, Piotr P. Buszman4, Tudor C. Poerner5, Francesco Lavarra6, Borja Ibáñez789, Yongcheol Kim10, Karl Mischke11, Miłosz Jaguszewski12, Juan Luis Gutiérrez-Chico13
DOI: 10.5603/CJ.2020.0109
Pubmed: 32929701
Cardiol J 2020;27(4):336-341.
  1. San Pedro Hospital, Logroño, Spain
  2. Department of Cardiology, Bristol Heart Instittute, Bristol, United Kingdom
  3. Cardiology Practice, München, Germany
  4. Cardiology Department, Andrzej Frycz-Modrzewski Kraków University, American Heart of Poland, Bielsko Biała, Poland
  5. Marienhospital, Aachen, Germany
  6. Jilin Heart Hospital, Changchun, China
  7. Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
  8. Department of Cardiology, IIS-Hospital Universitario Fundación Jiménez Díaz — Quironsalud, Madrid, Spain
  9. Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain
  10. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
  11. Leopoldina hospital Schweinfurt, Gustav- Adolf- Str. 8, Germany
  12. 1st Department of Cardiology Medical University of Gdansk, Poland
  13. Cardio Care Heart Centre, Ventura del Mar 11, 29660 Marbella, Spain

open access

Vol 27, No 4 (2020)
Submitted: 2020-07-28
Accepted: 2020-07-29
Published online: 2020-09-10


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ISCHEMIA trial: The long-awaited evidence to confirm our prejudices


Cardiology Journal


Vol 27, No 4 (2020)

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Cardiol J 2020;27(4):336-341.


Carlos Cortés
Thomas W. Johnson
Sigmund Silber
Piotr P. Buszman
Tudor C. Poerner
Francesco Lavarra
Borja Ibáñez
Yongcheol Kim
Karl Mischke
Miłosz Jaguszewski
Juan Luis Gutiérrez-Chico

References (22)
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  5. Hochman JS, Reynolds HR, Bangalore S, et al. ISCHEMIA Research Group. Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial. JAMA Cardiol. 2019; 4(3): 273–286.
  6. Spertus JA, Jones PG, Maron DJ, et al. ISCHEMIA Research Group. Health-Status Outcomes with Invasive or Conservative Care in Coronary Disease. N Engl J Med. 2020; 382(15): 1408–1419.
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  10. Lee SW, Lee PH, Ahn JM, et al. Randomized trial evaluating percutaneous coronary intervention for the treatment of chronic total occlusion. Circulation. 2019; 139(14): 1674–1683.
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  12. Tonino PAL, De Bruyne B, Pijls NHJ, et al. FAME Study Investigators. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med. 2009; 360(3): 213–224.
  13. Neumann F-J, Sousa-Uva M, Ahlsson A, et al. 2018 ESC/EACTS Guidelines on myocardial revascularization. Eur Heart J. 2019; 40: 87–165.
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  15. Jaguszewski M, Zabalza Cerdeiriña M, Alushi B, et al. How should I treat recurrent chest pain and systolic dysfunction after chemotherapy with anthracyclines? EuroIntervention. 2017; 12(13): 1674–1677.
  16. Gutiérrez-Chico JL, Zhao S, Chatzizisis YS. Vorticity: At the crossroads of coronary biomechanics and physiology. Atherosclerosis. 2018; 273: 115–116.
  17. Boden WE, O’Rourke RA, Teo KK, et al. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med. 2007; 356: 1503–1516.
  18. Härle T, Zeymer U, Hochadel M, et al. Real-world use of fractional flow reserve in Germany: results of the prospective ALKK coronary angiography and PCI registry. Clin Res Cardiol. 2017; 106(2): 140–150.
  19. Lee HS, Lee JM, Nam CW, et al. Consensus document for invasive coronary physiologic assessment in Asia-Pacific countries. Cardiol J. 2019; 26(3): 215–225.
  20. Sleight P. Debate: Subgroup analyses in clinical trials: fun to look at - but don’t believe them! Curr Control Trials Cardiovasc Med. 2000; 1(1): 25–27.
  21. Figulla HR, Lauten A, Maier LS, et al. Percutaneous Coronary Intervention in Stable Coronary Heart Disease -Is Less More? Dtsch Arztebl Int. 2020; 117(9): 137–144.
  22. Gutiérrez-Chico JL, Chen Y, Yu W, et al. Diagnostic accuracy and reproducibility of optical flow ratio for functional evaluation of coronary stenosis in a prospective series. Cardiol J. 2020 [Epub ahead of print].


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