open access
Colocalization of plaque macrophages and calcification in coronary plaques as detected by optical coherence tomography predicts cardiovascular outcome


- Department of Cardiology, University Hospital of the RWTH Aachen, Pauwelstr. 30, 52062, Germany
- Department of Electrophysiology, Heart Center University Leipzig, Germany
- Institute of Medical Statistics and Computational Biology (IMSB), University of Cologne, Faculty of Medicine and University Hospital Cologne, Germany
open access
Abstract
Abstract


Title
Colocalization of plaque macrophages and calcification in coronary plaques as detected by optical coherence tomography predicts cardiovascular outcome
Journal
Issue
Pages
303-306
Published online
2020-05-20
Page views
967
Article views/downloads
599
DOI
Pubmed
Bibliographic record
Cardiol J 2020;27(3):303-306.
Authors
Mathias Burgmaier
Andrea Milzi
Rosalia Dettori
Kathrin Burgmaier
Martin Hellmich
Mohammad Almalla
Nikolaus Marx
Sebastian Reith


- Kato K, Yonetsu T, Kim SJ, et al. Nonculprit plaques in patients with acute coronary syndromes have more vulnerable features compared with those with non-acute coronary syndromes: a 3-vessel optical coherence tomography study. Circ Cardiovasc Imaging. 2012; 5(4): 433–440.
- Reith S, Milzi A, Dettori R, et al. Predictors for target lesion microcalcifications in patients with stable coronary artery disease: an optical coherence tomography study. Clin Res Cardiol. 2018; 107(9): 763–771.
- Aikawa E, Nahrendorf M, Figueiredo JL, et al. Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo. Circulation. 2007; 116(24): 2841–2850.
- Nadra I, Mason JC, Philippidis P, et al. Proinflammatory activation of macrophages by basic calcium phosphate crystals via protein kinase C and MAP kinase pathways: a vicious cycle of inflammation and arterial calcification? Circ Res. 2005; 96(12): 1248–1256.
- Burgmaier M, Milzi A, Dettori R, et al. Co-localization of plaque macrophages with calcification is associated with a more vulnerable plaque phenotype and a greater calcification burden in coronary target segments as determined by OCT. PLoS One. 2018; 13(10): e0205984.
- Prati F, Romagnoli E, La Manna A, et al. Long-term consequences of optical coherence tomography findings during percutaneous coronary intervention: the Centro Per La Lotta Contro L'infarto - Optimization Of Percutaneous Coronary Intervention (CLI-OPCI) LATE study. EuroIntervention. 2018; 14(4): e443–e451.
- Naghavi M, Libby P, Falk E, et al. From vulnerable plaque to vulnerable patient. A call for new definitions and risk assessment strategies: Part I. Circulation. 2003; 108(14): 1664–1672.
- Vergallo R, Ren X, Yonetsu T, et al. Pancoronary plaque vulnerability in patients with acute coronary syndrome and ruptured culprit plaque: a 3-vessel optical coherence tomography study. Am Heart J. 2014; 167(1): 59–67.
- Tearney GJ, Regar E, Akasaka T, et al. Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation. J Am Coll Cardiol. 2012; 59(12): 1058–1072.
- Habara M, Otsuka F, Tsuchikane E, et al. In vivo tissue characterization of human atherosclerotic plaques by optical coherence tomography: A directional coronary atherectomy study with histopathologic confirmation. Int J Cardiol. 2018; 268: 1–10.