Vol 27, No 3 (2020)
Brief communication — Interventional cardiology
Published online: 2020-05-20

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Colocalization of plaque macrophages and calcification in coronary plaques as detected by optical coherence tomography predicts cardiovascular outcome

Mathias Burgmaier1, Andrea Milzi1, Rosalia Dettori1, Kathrin Burgmaier2, Martin Hellmich3, Mohammad Almalla1, Nikolaus Marx1, Sebastian Reith1
Pubmed: 32436586
Cardiol J 2020;27(3):303-306.


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  1. Kato K, Yonetsu T, Kim SJ, et al. Nonculprit plaques in patients with acute coronary syndromes have more vulnerable features compared with those with non-acute coronary syndromes: a 3-vessel optical coherence tomography study. Circ Cardiovasc Imaging. 2012; 5(4): 433–440.
  2. Reith S, Milzi A, Dettori R, et al. Predictors for target lesion microcalcifications in patients with stable coronary artery disease: an optical coherence tomography study. Clin Res Cardiol. 2018; 107(9): 763–771.
  3. Aikawa E, Nahrendorf M, Figueiredo JL, et al. Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo. Circulation. 2007; 116(24): 2841–2850.
  4. Nadra I, Mason JC, Philippidis P, et al. Proinflammatory activation of macrophages by basic calcium phosphate crystals via protein kinase C and MAP kinase pathways: a vicious cycle of inflammation and arterial calcification? Circ Res. 2005; 96(12): 1248–1256.
  5. Burgmaier M, Milzi A, Dettori R, et al. Co-localization of plaque macrophages with calcification is associated with a more vulnerable plaque phenotype and a greater calcification burden in coronary target segments as determined by OCT. PLoS One. 2018; 13(10): e0205984.
  6. Prati F, Romagnoli E, La Manna A, et al. Long-term consequences of optical coherence tomography findings during percutaneous coronary intervention: the Centro Per La Lotta Contro L'infarto - Optimization Of Percutaneous Coronary Intervention (CLI-OPCI) LATE study. EuroIntervention. 2018; 14(4): e443–e451.
  7. Naghavi M, Libby P, Falk E, et al. From vulnerable plaque to vulnerable patient. A call for new definitions and risk assessment strategies: Part I. Circulation. 2003; 108(14): 1664–1672.
  8. Vergallo R, Ren X, Yonetsu T, et al. Pancoronary plaque vulnerability in patients with acute coronary syndrome and ruptured culprit plaque: a 3-vessel optical coherence tomography study. Am Heart J. 2014; 167(1): 59–67.
  9. Tearney GJ, Regar E, Akasaka T, et al. Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation. J Am Coll Cardiol. 2012; 59(12): 1058–1072.
  10. Habara M, Otsuka F, Tsuchikane E, et al. In vivo tissue characterization of human atherosclerotic plaques by optical coherence tomography: A directional coronary atherectomy study with histopathologic confirmation. Int J Cardiol. 2018; 268: 1–10.