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Published online: 2020-03-18
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QRS duration and cardiovascular mortality in Asian patients with heart failure and preserved and reduced ejection fraction

Jonathan Yap, Yann Shan Keh, Tong Shen, Carolyn S.P. Lam, Shaw Yang Chia, Fazlur Rehman Jaufeerally, Wilson Ong, David Sim, Chi-Keong Ching
DOI: 10.5603/CJ.a2020.0041
·
Pubmed: 32207835

open access

Ahead of print
Research letter
Published online: 2020-03-18

Abstract

Background: We aim to study the association between QRS duration and mortality in our Asian heart failure cohort with HFpEF and HFrEF.

Methods: Consecutive patients admitted with heart failure from Jan 2008 to Dec 2009 were included. Preserved ejection fraction (EF) was defined as EF ≥50% and reduced EF as EF < 50%. All patients were followed-up for 5-7 years. Outcomes studied were overall mortality and cardiovascular mortality.

Results: A total of 666 HFpEF and 1032 HFrEF were included. In patients with HFpEF, the 5-year overall and cardiovascular mortality was 57% (n=381) and 28% (n=189) respectively. QRS duration was a significant predictor of cardiovascular (adjusted HR 1.010 (95% CI1.002-1.018), p=0.011) but not overall mortality (p=0.190). In patients with HFrEF, the 5-year overall and cardiovascular mortality was 65% (n=673) and 43.0% (n=444). QRS duration was a significant predictor of both overall (adjusted HR 1.005 (95% CI1.001-1.008), p=0.004) and cardiovascular mortality (adjusted HR 1.006 (95% CI1.002-1.010), p=0.003). A cut-off of 100ms was found to provide the optimal discriminatory AUC in both cohorts.

Conclusions: In our Asian heart failure cohort, QRS duration is a significant predictor of cardiovascular mortality in both HFpEF and HFrEF patients. QRS duration also significantly predicted overall mortality in HFrEF patients.

Abstract

Background: We aim to study the association between QRS duration and mortality in our Asian heart failure cohort with HFpEF and HFrEF.

Methods: Consecutive patients admitted with heart failure from Jan 2008 to Dec 2009 were included. Preserved ejection fraction (EF) was defined as EF ≥50% and reduced EF as EF < 50%. All patients were followed-up for 5-7 years. Outcomes studied were overall mortality and cardiovascular mortality.

Results: A total of 666 HFpEF and 1032 HFrEF were included. In patients with HFpEF, the 5-year overall and cardiovascular mortality was 57% (n=381) and 28% (n=189) respectively. QRS duration was a significant predictor of cardiovascular (adjusted HR 1.010 (95% CI1.002-1.018), p=0.011) but not overall mortality (p=0.190). In patients with HFrEF, the 5-year overall and cardiovascular mortality was 65% (n=673) and 43.0% (n=444). QRS duration was a significant predictor of both overall (adjusted HR 1.005 (95% CI1.001-1.008), p=0.004) and cardiovascular mortality (adjusted HR 1.006 (95% CI1.002-1.010), p=0.003). A cut-off of 100ms was found to provide the optimal discriminatory AUC in both cohorts.

Conclusions: In our Asian heart failure cohort, QRS duration is a significant predictor of cardiovascular mortality in both HFpEF and HFrEF patients. QRS duration also significantly predicted overall mortality in HFrEF patients.

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Keywords

heart failure; QRS duration; presereved ejection fraction; reduced ejection fraction; mortality

About this article
Title

QRS duration and cardiovascular mortality in Asian patients with heart failure and preserved and reduced ejection fraction

Journal

Cardiology Journal

Issue

Ahead of print

Published online

2020-03-18

DOI

10.5603/CJ.a2020.0041

Pubmed

32207835

Keywords

heart failure
QRS duration
presereved ejection fraction
reduced ejection fraction
mortality

Authors

Jonathan Yap
Yann Shan Keh
Tong Shen
Carolyn S.P. Lam
Shaw Yang Chia
Fazlur Rehman Jaufeerally
Wilson Ong
David Sim
Chi-Keong Ching

References (10)
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