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Original Article
Published online: 2019-11-06
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Acute effects of difference in glucose intake on arterial stiffness in healthy subjects

Ryota Kobayashi, Kaori Sato, Miki Sakazaki, Yukie Nagai, Soichiro Iwanuma, Nobuyuki Ohashi, Takeo Hashiguchi
DOI: 10.5603/CJ.a2019.0108
·
Pubmed: 31702047

open access

Ahead of print
Original articles
Published online: 2019-11-06

Abstract

Background: Post-prandial hyperglycemia is associated with higher cardiovascular risk, which causes arterial stiffening and impaired function. Although post-prandial increases in blood glucose are proportional to the level of intake, the acute effects of different glucose intakes on arterial stiffness have not been fully characterized. The present study aimed to determine the acute effects of differences in glucose intake on arterial stiffness. Methods: Six healthy middle-aged and elderly individuals (mean age, 60.0 ± 12.1 years) were orally administered 15, 20, and 25 g of glucose on separate days in a randomized, controlled, cross-over fashion. Brachial-ankle pulse wave velocity, heart-brachial pulse wave velocity, cardio-ankle vascular index, brachial and ankle blood pressure, heart rate, and blood glucose and serum insulin concentrations before and 30, 60, and 90 min after glucose ingestion were measured. Results: Compared to baseline, brachial-ankle pulse wave velocity was higher at 30, 60 and 90 min after ingestion of 25 g glucose, and higher at 90 min after ingestion of 20 g glucose, but at no time points after ingestion of 15 g. Cardio-ankle vascular index was higher at 60 min than at baseline after ingestion of 25 g glucose, but not after ingestion of 15 or 20 g. Conclusions: These results suggest that brachial-ankle pulse wave velocity and cardio-ankle vascular index is affected by the quantity of glucose ingested. Proposed presently is that glucose intake should be reduced at each meal to avoid increases in brachial-ankle pulse wave velocity and cardio-ankle vascular index during acute hyperglycemia.

Abstract

Background: Post-prandial hyperglycemia is associated with higher cardiovascular risk, which causes arterial stiffening and impaired function. Although post-prandial increases in blood glucose are proportional to the level of intake, the acute effects of different glucose intakes on arterial stiffness have not been fully characterized. The present study aimed to determine the acute effects of differences in glucose intake on arterial stiffness. Methods: Six healthy middle-aged and elderly individuals (mean age, 60.0 ± 12.1 years) were orally administered 15, 20, and 25 g of glucose on separate days in a randomized, controlled, cross-over fashion. Brachial-ankle pulse wave velocity, heart-brachial pulse wave velocity, cardio-ankle vascular index, brachial and ankle blood pressure, heart rate, and blood glucose and serum insulin concentrations before and 30, 60, and 90 min after glucose ingestion were measured. Results: Compared to baseline, brachial-ankle pulse wave velocity was higher at 30, 60 and 90 min after ingestion of 25 g glucose, and higher at 90 min after ingestion of 20 g glucose, but at no time points after ingestion of 15 g. Cardio-ankle vascular index was higher at 60 min than at baseline after ingestion of 25 g glucose, but not after ingestion of 15 or 20 g. Conclusions: These results suggest that brachial-ankle pulse wave velocity and cardio-ankle vascular index is affected by the quantity of glucose ingested. Proposed presently is that glucose intake should be reduced at each meal to avoid increases in brachial-ankle pulse wave velocity and cardio-ankle vascular index during acute hyperglycemia.

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Keywords

arterial stiffness, brachial-ankle pulse wave velocity, cardio-ankle vascular index, quantity of glucose ingestion, healthy subjects

About this article
Title

Acute effects of difference in glucose intake on arterial stiffness in healthy subjects

Journal

Cardiology Journal

Issue

Ahead of print

Article type

Original Article

Published online

2019-11-06

DOI

10.5603/CJ.a2019.0108

Pubmed

31702047

Keywords

arterial stiffness
brachial-ankle pulse wave velocity
cardio-ankle vascular index
quantity of glucose ingestion
healthy subjects

Authors

Ryota Kobayashi
Kaori Sato
Miki Sakazaki
Yukie Nagai
Soichiro Iwanuma
Nobuyuki Ohashi
Takeo Hashiguchi

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