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Research paper
Published online: 2019-09-03
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Evaluation of the InterTAK Diagnostic Score in differentiating Takotsubo syndrome from acute coronary syndrome. A single center experience

Judyta Samul-Jastrzębska, Marek Roik, Dominik Wretowski, Andrzej Łabyk, Antonina Ślubowska, Anna Bizoń, Marzanna Paczyńska, Katarzyna Kurnicka, Piotr Pruszczyk, Michał Ciurzyński
DOI: 10.5603/CJ.a2019.0086
·
Pubmed: 31489610

open access

Ahead of print
Original articles
Published online: 2019-09-03

Abstract

Background: The aim of this study was to evaluate the usefulness of a novel clinical score - the InterTAK Diagnostic Score in differentiating Takotsubo syndrome (TTS) from acute coronary syndrome (ACS).

Methods: Medical records of 40 consecutive patients with ACS and 20 patients with TTS were managed and retrospectively analyzed at the documented center. Each patient was evaluated using the InterTAK Diagnostic Score. To illustrate the diagnostic ability of the score, a receiver operating characteristic (ROC) curve was performed.

Results: Takotsube syndrome patients were more often female compared to the ACS group (70% vs. 27.5%, p = 0.002), an emotional trigger was more prevalent among the TTS group (65% vs. 7.5%, p < 0.001). The area under the curve (AUC) for the score was 0.885 (95% confidence interval [CI] 0.78–0.97). Using a cut-off value of 45 points, the sum of sensitivity and specificity was the highest. However, when patients with a score of ≥ 50 were diagnosed as TTS, 85% were diagnosed correctly. When patients with score ≤ 31 were diagnosed as ACS, 92% were diagnosed correctly.

Conclusions: The InterTAK Diagnostic Score might help in differentiating TTS from ACSs with high sensitivity and specificity. This finding requires further investigation to confirm its clinical utility.

Abstract

Background: The aim of this study was to evaluate the usefulness of a novel clinical score - the InterTAK Diagnostic Score in differentiating Takotsubo syndrome (TTS) from acute coronary syndrome (ACS).

Methods: Medical records of 40 consecutive patients with ACS and 20 patients with TTS were managed and retrospectively analyzed at the documented center. Each patient was evaluated using the InterTAK Diagnostic Score. To illustrate the diagnostic ability of the score, a receiver operating characteristic (ROC) curve was performed.

Results: Takotsube syndrome patients were more often female compared to the ACS group (70% vs. 27.5%, p = 0.002), an emotional trigger was more prevalent among the TTS group (65% vs. 7.5%, p < 0.001). The area under the curve (AUC) for the score was 0.885 (95% confidence interval [CI] 0.78–0.97). Using a cut-off value of 45 points, the sum of sensitivity and specificity was the highest. However, when patients with a score of ≥ 50 were diagnosed as TTS, 85% were diagnosed correctly. When patients with score ≤ 31 were diagnosed as ACS, 92% were diagnosed correctly.

Conclusions: The InterTAK Diagnostic Score might help in differentiating TTS from ACSs with high sensitivity and specificity. This finding requires further investigation to confirm its clinical utility.

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Keywords

Takotsubo syndrome, broken heart syndrome, acute coronary syndrome, clinical score

About this article
Title

Evaluation of the InterTAK Diagnostic Score in differentiating Takotsubo syndrome from acute coronary syndrome. A single center experience

Journal

Cardiology Journal

Issue

Ahead of print

Article type

Research paper

Published online

2019-09-03

DOI

10.5603/CJ.a2019.0086

Pubmed

31489610

Keywords

Takotsubo syndrome
broken heart syndrome
acute coronary syndrome
clinical score

Authors

Judyta Samul-Jastrzębska
Marek Roik
Dominik Wretowski
Andrzej Łabyk
Antonina Ślubowska
Anna Bizoń
Marzanna Paczyńska
Katarzyna Kurnicka
Piotr Pruszczyk
Michał Ciurzyński

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