Vol 28, No 4 (2021)
Original Article
Published online: 2019-03-08
The effect of Cistus incanus herbal tea supplementation on oxidative stress markers and lipid profile in healthy adults
Abstract
Background: Oxidative stress and dyslipidemia play a critical role in the development of cardiovascular disease (CVD). Regular intake of polyphenol-rich diets is associated with a reduced risk of CVDs.
Methods: The present study was a pilot study with 24 healthy volunteers and was designed to determine if a 12-week administration of Cistus incanus herbal tea, containing phenolic acids and flavonoids, reduces cardiovascular risk factors including oxidative stress and dyslipidemia in healthy adults. Phenolic compounds profile and antibacterial activity of Cistus incanus infusion were also measured.
Results: Herbal infusion led to improvement in lipid profile by increase (D4%, p = 0.033) high-density lipoprotein cholesterol concentration and decrease triglyceride (D14%, p = 0.013) concentrations. In addition, the Cistus incanus diet was associated with decreased serum concentrations of malondialdehyde (D16%, p < 0.01) and advanced oxidation protein products (D18%, p < 0.001).
Conclusions: Cistus incanus administration decreases cardiovascular risk factors including oxidative stress and dyslipidemia and this action supports the idea of using Cistus incanus tea on a daily basis as an effective dietary component for prevention of atherosclerotic CVD.
Keywords: Cistus incanuslipid profileoxidative stress markers
References
- Barrajón-Catalán E, Fernández-Arroyo S, Roldán C, et al. A systematic study of the polyphenolic composition of aqueous extracts deriving from several Cistus genus species: evolutionary relationship. Phytochem Anal. 2011; 22(4): 303–312.
- Scalbert A, Manach C, Morand C, et al. Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr. 2005; 45(4): 287–306.
- Reis JF, Monteiro VV, de Souza Gomes R, et al. Action mechanism and cardiovascular effect of anthocyanins: a systematic review of animal and human studies. J Transl Med. 2016; 14(1): 315.
- Tressera-Rimbau A, Arranz S, Eder M, et al. Dietary Polyphenols in the Prevention of Stroke. Oxid Med Cell Longev. 2017; 2017: 7467962.
- Manach C, Mazur A, Scalbert A. Polyphenols and prevention of cardiovascular diseases. Curr Opin Lipidol. 2005; 16(1): 77–84.
- Oak MH, Auger C, Belcastro E, et al. Potential mechanisms underlying cardiovascular protection by polyphenols: Role of the endothelium. Free Radic Biol Med. 2018; 122: 161–170.
- Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev. 2009; 2(5): 270–278.
- Cutler BR, Petersen C, Anandh Babu PV. Mechanistic insights into the vascular effects of blueberries: Evidence from recent studies. Mol Nutr Food Res. 2017; 61(6).
- Kalus U, Grigorov A, Kadecki O, et al. Cistus incanus (CYSTUS052) for treating patients with infection of the upper respiratory tract. A prospective, randomised, placebo-controlled clinical study. Antiviral Res. 2009; 84(3): 267–271.
- MacKness B, Mackness MI, Durrington PN, et al. Paraoxonase activity in two healthy populations with differing rates of coronary heart disease. Eur J Clin Invest. 2000; 30(1): 4–10.
- Nakanishi M, Takanami Y, Maruyama T, et al. The ratio of serum paraoxonase/arylesterase activity using an improved assay for arylesterase activity to discriminate PON1(R192) from PON1(Q192). J Atheroscler Thromb. 2003; 10(6): 337–342.
- Yokode M, Kita T, Kikawa Y, et al. Stimulated arachidonate metabolism during foam cell transformation of mouse peritoneal macrophages with oxidized low density lipoprotein. J Clin Invest. 1988; 81(3): 720–729.
- Witko-Sarsat V, Friedlander M, Capeillère-Blandin C, et al. Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int. 1996; 49(5): 1304–1313.
- Singleton V, Orthofer R, Lamuela-Raventós R. [14] Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent. Methods in Enzymology. Academic Press. 1999; 299: 152–178.
- European Pharmacopeia. European Pharmacopoeia. 2002.
- Polish Pharmacopoeia VI. pp. 150. Warsaw: Polish Pharmacological Society. 2002: 150.
- Abdelmageed OH, Khashaba PY, Askal HF, et al. Selective spectrophotometric determination of ascorbic acid in drugs and foods. Talanta. 1995; 42(4): 573–579.
- Tuberoso C, Rosa A, Bifulco E, et al. Chemical composition and antioxidant activities of Myrtus communis L. berries extracts. Food Chemistry. 2010; 123(4): 1242–1251.
- Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem. 1996; 239(1): 70–76.
- Viapiana A, Konopacka A, Waleron K, et al. Cistus incanus L. commercial products as a good source of polyphenols in human diet. Industrial Crops and Products. 2017; 107: 297–304.
- Martínez-Huélamo M, Vallverdú-Queralt A, Di Lecce G, et al. Bioavailability of tomato polyphenols is enhanced by processing and fat addition: Evidence from a randomized feeding trial. Mol Nutr Food Res. 2016; 60(7): 1578–1589.
- Khurana S, Venkataraman K, Hollingsworth A, et al. Polyphenols: benefits to the cardiovascular system in health and in aging. Nutrients. 2013; 5(10): 3779–3827.
- Litvinov D, Mahini H, Garelnabi M. Antioxidant and anti-inflammatory role of paraoxonase 1: implication in arteriosclerosis diseases. N Am J Med Sci. 2012; 4(11): 523–532.
- Young JF, Nielsen SE, Haraldsdóttir J, et al. Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status. Am J Clin Nutr. 1999; 69(1): 87–94.
- Sharpe PC, McGrath LT, McClean E, et al. Effect of red wine consumption on lipoprotein (a) and other risk factors for atherosclerosis. Qjm. 1995; 88: 101–108.
- Chopra M, Fitzsimons PE, Strain JJ, et al. Nonalcoholic red wine extract and quercetin inhibit LDL oxidation without affecting plasma antioxidant vitamin and carotenoid concentrations. Clin Chem. 2000; 46: 1162–1170.
- Puddey IB, Croft KD, Abdu-Amsha Caccetta R, et al. Alcohol, free radicals and antioxidants. Novartis Found Symp. 1998; 216: 51–62; discussion 63.
- Karim M, McCormick K, Kappagoda CT. Effects of cocoa extracts on endothelium-dependent relaxation. J Nutr. 2000; 130(8S Suppl): 2105S–2108S.
- Wollny T, Aiello L, Di To, et al. Modulation of haemostatic function and prevention of experimental thrombosis by red wine in rats: a role for increased nitric oxide production. Br J Pharmacol. 1999; 127: 747–755.
- Baba S, Osakabe N, Kato Y, et al. Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans. Am J Clin Nutr. 2007; 85(3): 709–717.
- Mollace V, Sacco I, Janda E, et al. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies. Fitoterapia. 2011; 82(3): 309–316.
- Wang D, Chen C, Wang Yu, et al. Effect of black tea consumption on blood cholesterol: a meta-analysis of 15 randomized controlled trials. PLoS One. 2014; 9(9): e107711.
- Zhao Y, Asimi S, Wu K, et al. Black tea consumption and serum cholesterol concentration: Systematic review and meta-analysis of randomized controlled trials. Clin Nutr. 2015; 34(4): 612–619.
- Petereit F, Kolodziej H, Nahrstedt A. Flavan-3-ols and proanthocyanidins from Cistus incanus. Phytochemistry. 1991; 30(3): 981–985.
- Santagati NA, Salerno L, Attaguile G, et al. Simultaneous determination of catechins, rutin, and gallic acid in Cistus species extracts by HPLC with diode array detection. J Chromatogr Sci. 2008; 46(2): 150–156.
- Riehle P, Vollmer M, Rohn S. Phenolic compounds in Cistus incanus herbal infusions — Antioxidant capacity and thermal stability during the brewing process. Food Res Int. 2013; 53(2): 891–899.
- Wittpahl G, Kölling-Speer I, Basche S, et al. The polyphenolic composition of cistus incanus herbal tea and its antibacterial and anti-adherent activity against streptococcus mutans. Planta Med. 2015; 81(18): 1727–1735.
- Deng GF, Lin Xi, Xu XR, et al. Antioxidant capacities and total phenolic contents of 56 vegetables. J Functional Foods. 2013; 5(1): 260–266.
- Konieczynski P, Viapiana A, Wesolowski M. Comparison of Infusions from Black and Green Teas (Camellia sinensis L. Kuntze) and Erva-mate (Ilex paraguariensis A. St.-Hil.) Based on the Content of Essential Elements, Secondary Metabolites, and Antioxidant Activity. Food Analytical Methods. 2017; 10(9): 3063–3070.
