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Published online: 2019-03-26
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Selected matrix metalloproteinases activity and hypertension-mediated organ damage in relation to uric acid serum level

Krystian Gruszka, Marek Rajzer, Tomasz Drożdż, Wiktoria Wojciechowska, Tomasz Pizoń, Kamila Migacz-Gruszka, Danuta Czarnecka
DOI: 10.5603/CJ.a2019.0033
·
Pubmed: 30994184

open access

Ahead of print
Original articles
Published online: 2019-03-26

Abstract

Background: Atherosclerosis is as a systemic inflammatory disease associated with the activation of many mediators, including matrix metalloproteinases (MMPs), and may be amplified by abnormal high serum uric acid (UA) concentration (hyperuricemia, HU). The aim of the study was to determine the relationship between serum UA concentration and activity of MMPs and their correlation with the hypertension-mediated organ damage (HMOD) intensity.

Methods: 109 patients untreated with antihypertensive, hypolipemic or urate-lowering drugs with diagnosed stage 1–2 essential hypertension were included in this study. In all participants blood pressure (BP) was measured, carotid-femoral pulse wave velocity (PWV), intima–media thickness (IMT),  echocardiography and blood tests including UA, lipids and serum concentrations of MMPs (1, 2, 3, 9) were observed. The participants were divided into hyper- and normuricemic groups.

Results: Uric acid concentration in the whole study group positively correlated with some HMOD parameters (IMT, PWV, left ventricular mass index, left atrial dimension). Among the studied metalloproteinases only MMP-3 activity positively correlated with serum UA concentration independently of age, body mass index and serum lipids (R2 = 0.11, p = 0.048). Multivariate regression analysis showed positive association between IMT and BP, UA concentration and MMP-3 activity, independently of waist circumference and serum lipids (R2 = 0.328, p < 0.002). Patients with HU were characterized by higher activity of MMP-3 than those without (19.41 [14.45; 21.74] vs. 13.98 [9.52; 18.97] ng/mL, p = 0.016).

Conclusions: The present results may support the thesis that UA and the increased by UA activity of MMPs may take part in the development of HMOD, especially IMT.

Abstract

Background: Atherosclerosis is as a systemic inflammatory disease associated with the activation of many mediators, including matrix metalloproteinases (MMPs), and may be amplified by abnormal high serum uric acid (UA) concentration (hyperuricemia, HU). The aim of the study was to determine the relationship between serum UA concentration and activity of MMPs and their correlation with the hypertension-mediated organ damage (HMOD) intensity.

Methods: 109 patients untreated with antihypertensive, hypolipemic or urate-lowering drugs with diagnosed stage 1–2 essential hypertension were included in this study. In all participants blood pressure (BP) was measured, carotid-femoral pulse wave velocity (PWV), intima–media thickness (IMT),  echocardiography and blood tests including UA, lipids and serum concentrations of MMPs (1, 2, 3, 9) were observed. The participants were divided into hyper- and normuricemic groups.

Results: Uric acid concentration in the whole study group positively correlated with some HMOD parameters (IMT, PWV, left ventricular mass index, left atrial dimension). Among the studied metalloproteinases only MMP-3 activity positively correlated with serum UA concentration independently of age, body mass index and serum lipids (R2 = 0.11, p = 0.048). Multivariate regression analysis showed positive association between IMT and BP, UA concentration and MMP-3 activity, independently of waist circumference and serum lipids (R2 = 0.328, p < 0.002). Patients with HU were characterized by higher activity of MMP-3 than those without (19.41 [14.45; 21.74] vs. 13.98 [9.52; 18.97] ng/mL, p = 0.016).

Conclusions: The present results may support the thesis that UA and the increased by UA activity of MMPs may take part in the development of HMOD, especially IMT.

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Keywords

arterial hypertension, uric acid, hyperuricemia, matrix metalloproteinases, metabolic syndrome

About this article
Title

Selected matrix metalloproteinases activity and hypertension-mediated organ damage in relation to uric acid serum level

Journal

Cardiology Journal

Issue

Ahead of print

Article type

Original Article

Published online

2019-03-26

DOI

10.5603/CJ.a2019.0033

Pubmed

30994184

Keywords

arterial hypertension
uric acid
hyperuricemia
matrix metalloproteinases
metabolic syndrome

Authors

Krystian Gruszka
Marek Rajzer
Tomasz Drożdż
Wiktoria Wojciechowska
Tomasz Pizoń
Kamila Migacz-Gruszka
Danuta Czarnecka

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