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Research paper
Published online: 2019-03-14
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The role of hemostatic markers as venous stenosis or occlusion predictors following first transvenous cardiac device implantation

Andrzej Cacko, Eliza Kozyra-Pydyś, Monika Gawałko, Grzegorz Opolski, Marcin Grabowski
DOI: 10.5603/CJ.a2019.0030
·
Pubmed: 30912577

open access

Ahead of print
Original articles
Published online: 2019-03-14

Abstract

Background: Among patients with implanted cardiac implantable electronic device (CIED), ipsilateral upper extremity vein stenosis or occlusion (VSO) is observed more frequently than the in general population. However, there are no data available concerning relationship between hemostatic markers (and their dynamics) and occurrence of VSO. The aim of this study was to assess the predictive value of beta-thromboglobulin, von Wilebrand factor, fibrynogen and D-dimer for VSO development among first time CIED recipients. Methods: We performed a single-center, prospective study of consecutive first time CIED recipients. In an ultrasound examination before CIED implantation the presence of upper extremity VSO was excluded. Biochemical data were collected from all the patients before CIED implantation (first measuring), up to seven days (second measuring) and six months after the operation (third measuring). Primary endpoint was defined as the presence of upper extremity VSO at the implantation site during the ultrasound examination six months after the operation. Results: The study included 71 patients (mean age 73.1 + 10.5 years; 39 (55%) male). The incidence of VSO within 6-months follow up was 21.1%. Average concentrations of hemostatic markers increased significantly in all the patients immediately after CIED implantation. Serial hemostatic marker concentrations were similar in patients who met and did not meet the primary endpoint, apart from von Wilebrand factor. Its mean concentration was significantly elevated in a group who reached primary endpoint (p = 0.032). Conclusion: A significant increase in von Wilebrand factor concentration at six months post implantation may be a marker for VSO occurrence.

Abstract

Background: Among patients with implanted cardiac implantable electronic device (CIED), ipsilateral upper extremity vein stenosis or occlusion (VSO) is observed more frequently than the in general population. However, there are no data available concerning relationship between hemostatic markers (and their dynamics) and occurrence of VSO. The aim of this study was to assess the predictive value of beta-thromboglobulin, von Wilebrand factor, fibrynogen and D-dimer for VSO development among first time CIED recipients. Methods: We performed a single-center, prospective study of consecutive first time CIED recipients. In an ultrasound examination before CIED implantation the presence of upper extremity VSO was excluded. Biochemical data were collected from all the patients before CIED implantation (first measuring), up to seven days (second measuring) and six months after the operation (third measuring). Primary endpoint was defined as the presence of upper extremity VSO at the implantation site during the ultrasound examination six months after the operation. Results: The study included 71 patients (mean age 73.1 + 10.5 years; 39 (55%) male). The incidence of VSO within 6-months follow up was 21.1%. Average concentrations of hemostatic markers increased significantly in all the patients immediately after CIED implantation. Serial hemostatic marker concentrations were similar in patients who met and did not meet the primary endpoint, apart from von Wilebrand factor. Its mean concentration was significantly elevated in a group who reached primary endpoint (p = 0.032). Conclusion: A significant increase in von Wilebrand factor concentration at six months post implantation may be a marker for VSO occurrence.

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Keywords

cardiac implanted electronic devices, vein stenosis or occlusion, hemostatic markers

Supplementary Files (1)
Table S1. Clinical characteristics of the patients at the time of inclusion in the study.
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About this article
Title

The role of hemostatic markers as venous stenosis or occlusion predictors following first transvenous cardiac device implantation

Journal

Cardiology Journal

Issue

Ahead of print

Article type

Research paper

Published online

2019-03-14

DOI

10.5603/CJ.a2019.0030

Pubmed

30912577

Keywords

cardiac implanted electronic devices
vein stenosis or occlusion
hemostatic markers

Authors

Andrzej Cacko
Eliza Kozyra-Pydyś
Monika Gawałko
Grzegorz Opolski
Marcin Grabowski

References (18)
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