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Cardiac sarcoidosis and ventricular arrhythmias. A rare association of a rare disease. A retrospective cohort study from the National Inpatient Sample and current evidence for management
Affiliations- Department of Medicine, Unity Hospital, 1555 Long Pond Rd, 14626 Rochester, New York, United States
- Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States
- Department of Cardiology, Rochester Regional Health, New York, United States
- chool of Health Sciences, Rochester Institute of Technology, New York, United States
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Abstract
Background: Sarcoidosis is an increasingly recognized multi-systemic condition. Cardiac sarcoidosis is associated with ventricular arrhythmias and higher mortality rates. Little epidemiological data is available regarding the disease and associated ventricular arrhythmias.
Methods: Data from the National Inpatient Sample (NIS) database 2012–2014, were reviewed. Discharges associated with sarcoidosis were identified as the target population using relevant ICD-9-CM codes. Primary outcome was a diagnosis of ventricular tachycardia (VT) in the sarcoidosis population. Secondary outcomes include rate of ventricular fibrillation (VF) and cardiac arrest. Subgroup analyses were performed to examine the association of VT with multiple potential confounding clinical variables.
Results: Of 18,013,878 health encounters, 46,289 (0.26%) subjects had a diagnosis of sarcoidosis. VT and VF were more prevalent among patients with sarcoidosis compared to those without a diagnosis of sarcoidosis (2.29% vs. 1.22%; p < 0.001 and 0.25% vs. 0.21%; p < 0.001, respectively). Sarcoidosis was also associated with a higher prevalence of cardiac arrest (0.72% vs. 0.6%; p < 0.001). In unadjusted analyses, all examined comorbidities were significantly more common in those with sarcoidosis, including diabetes mellitus (31.6% vs. 21.25%; p < 0.001), hypertension (65.2% vs. 51.74%; p < 0.001), chronic kidney disease (21.09% vs. 14.02%; p < 0.001), heart failure (24.87% vs. 15%; p < 0.001) and acute coronary syndrome (4.32% vs. 3.35%; p < 0.001).
Conclusions: The present study showed that sarcoidosis was associated with increased rates of ventricular tachyarrhythmia, which can affect the overall disease morbidity and mortality.
Abstract
Background: Sarcoidosis is an increasingly recognized multi-systemic condition. Cardiac sarcoidosis is associated with ventricular arrhythmias and higher mortality rates. Little epidemiological data is available regarding the disease and associated ventricular arrhythmias.
Methods: Data from the National Inpatient Sample (NIS) database 2012–2014, were reviewed. Discharges associated with sarcoidosis were identified as the target population using relevant ICD-9-CM codes. Primary outcome was a diagnosis of ventricular tachycardia (VT) in the sarcoidosis population. Secondary outcomes include rate of ventricular fibrillation (VF) and cardiac arrest. Subgroup analyses were performed to examine the association of VT with multiple potential confounding clinical variables.
Results: Of 18,013,878 health encounters, 46,289 (0.26%) subjects had a diagnosis of sarcoidosis. VT and VF were more prevalent among patients with sarcoidosis compared to those without a diagnosis of sarcoidosis (2.29% vs. 1.22%; p < 0.001 and 0.25% vs. 0.21%; p < 0.001, respectively). Sarcoidosis was also associated with a higher prevalence of cardiac arrest (0.72% vs. 0.6%; p < 0.001). In unadjusted analyses, all examined comorbidities were significantly more common in those with sarcoidosis, including diabetes mellitus (31.6% vs. 21.25%; p < 0.001), hypertension (65.2% vs. 51.74%; p < 0.001), chronic kidney disease (21.09% vs. 14.02%; p < 0.001), heart failure (24.87% vs. 15%; p < 0.001) and acute coronary syndrome (4.32% vs. 3.35%; p < 0.001).
Conclusions: The present study showed that sarcoidosis was associated with increased rates of ventricular tachyarrhythmia, which can affect the overall disease morbidity and mortality.
Keywords
cardiac sarcoidosis, ventricular tachycardia, ventricular fibrillation, cardiac death
About this articleTitle
Cardiac sarcoidosis and ventricular arrhythmias. A rare association of a rare disease. A retrospective cohort study from the National Inpatient Sample and current evidence for management
Journal
Issue
Pages
272-277
Published online
2018-09-07
Page views
2264
Article views/downloads
1010
DOI
Pubmed
Bibliographic record
Cardiol J 2020;27(3):272-277.
Keywords
cardiac sarcoidosis
ventricular tachycardia
ventricular fibrillation
cardiac death
Authors
Amr Salama
Abdullah Abdullah
Abdul Wahab
George Eigbire
Ryan Hoefen
Richard Alweis
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