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The usefulness of selected biomarkers in aortic regurgitation
Affiliations- Department of Acquired Cardiac Defects, Institute of Cardiology, Alpejska 42, Warsaw, Poland
- Department of Cardiosurgery and Transplantology, Institute of Cardiology, Warsaw, Poland
open access
Abstract
Background: The aim of the study was to investigate the prognostic value of selected biomarkers in
patients with aortic regurgitation undergoing valve surgery.
Methods: A prospective study was conducted on a group of consecutive patients with hemodynamically significant aortic regurgitation that underwent elective aortic valve surgery. The primary endpoint was 30-day mortality and any major adverse event within 30 days.
Results: The study group included 205 consecutive patients who underwent replacement or repair of the aortic valve. The primary endpoint occurred in 72 patients. At multivariate analysis red cell distribution width (RDW; p = 0.03) and high-sensitivity troponin T (hs-TnT; p = 0.02) remained independent predictors of the major complications including death.
Conclusions: Elevated preoperative RDW and hs-TnT were associated with a poorer outcome following
aortic valve surgery.
Abstract
Background: The aim of the study was to investigate the prognostic value of selected biomarkers in
patients with aortic regurgitation undergoing valve surgery.
Methods: A prospective study was conducted on a group of consecutive patients with hemodynamically significant aortic regurgitation that underwent elective aortic valve surgery. The primary endpoint was 30-day mortality and any major adverse event within 30 days.
Results: The study group included 205 consecutive patients who underwent replacement or repair of the aortic valve. The primary endpoint occurred in 72 patients. At multivariate analysis red cell distribution width (RDW; p = 0.03) and high-sensitivity troponin T (hs-TnT; p = 0.02) remained independent predictors of the major complications including death.
Conclusions: Elevated preoperative RDW and hs-TnT were associated with a poorer outcome following
aortic valve surgery.
Keywords
aortic regurgitation; biomarkers; EuroSCORE II; risk stratification; high-sensitivity troponin T
About this articleTitle
The usefulness of selected biomarkers in aortic regurgitation
Journal
Issue
Pages
477-482
Published online
2018-09-13
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1420
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1053
DOI
Pubmed
Bibliographic record
Cardiol J 2019;26(5):477-482.
Keywords
aortic regurgitation
biomarkers
EuroSCORE II
risk stratification
high-sensitivity troponin T
Authors
Piotr Duchnowski
Tomasz Hryniewiecki
Mariusz Kuśmierczyk
Piotr Szymański
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