open access

Vol 26, No 5 (2019)
Original articles — Clinical cardiology
Published online: 2018-09-13
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The usefulness of selected biomarkers in aortic regurgitation

Piotr Duchnowski, Tomasz Hryniewiecki, Mariusz Kuśmierczyk, Piotr Szymański
DOI: 10.5603/CJ.a2018.0108
·
Pubmed: 30234893
·
Cardiol J 2019;26(5):477-482.

open access

Vol 26, No 5 (2019)
Original articles — Clinical cardiology
Published online: 2018-09-13

Abstract

Background: The aim of the study was to investigate the prognostic value of selected biomarkers in
patients with aortic regurgitation undergoing valve surgery.


Methods: A prospective study was conducted on a group of consecutive patients with hemodynamically significant aortic regurgitation that underwent elective aortic valve surgery. The primary endpoint was 30-day mortality and any major adverse event within 30 days.


Results: The study group included 205 consecutive patients who underwent replacement or repair of the aortic valve. The primary endpoint occurred in 72 patients. At multivariate analysis red cell distribution width (RDW; p = 0.03) and high-sensitivity troponin T (hs-TnT; p = 0.02) remained independent predictors of the major complications including death.


Conclusions: Elevated preoperative RDW and hs-TnT were associated with a poorer outcome following
aortic valve surgery.

Abstract

Background: The aim of the study was to investigate the prognostic value of selected biomarkers in
patients with aortic regurgitation undergoing valve surgery.


Methods: A prospective study was conducted on a group of consecutive patients with hemodynamically significant aortic regurgitation that underwent elective aortic valve surgery. The primary endpoint was 30-day mortality and any major adverse event within 30 days.


Results: The study group included 205 consecutive patients who underwent replacement or repair of the aortic valve. The primary endpoint occurred in 72 patients. At multivariate analysis red cell distribution width (RDW; p = 0.03) and high-sensitivity troponin T (hs-TnT; p = 0.02) remained independent predictors of the major complications including death.


Conclusions: Elevated preoperative RDW and hs-TnT were associated with a poorer outcome following
aortic valve surgery.

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Keywords

aortic regurgitation; biomarkers; EuroSCORE II; risk stratification; high-sensitivity troponin T

About this article
Title

The usefulness of selected biomarkers in aortic regurgitation

Journal

Cardiology Journal

Issue

Vol 26, No 5 (2019)

Pages

477-482

Published online

2018-09-13

DOI

10.5603/CJ.a2018.0108

Pubmed

30234893

Bibliographic record

Cardiol J 2019;26(5):477-482.

Keywords

aortic regurgitation
biomarkers
EuroSCORE II
risk stratification
high-sensitivity troponin T

Authors

Piotr Duchnowski
Tomasz Hryniewiecki
Mariusz Kuśmierczyk
Piotr Szymański

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