open access

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Original Article
Published online: 2018-06-14
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The atherogenic index of plasma and its impact on recanalization of chronic total occlusion

Jan-Erik Guelker, Alexander Bufe, Christian Blockhaus, Knut Kroeger, Thomas Rock, Ibrahim Akin, Michael Behnes, Kambis Mashayekhi
DOI: 10.5603/CJ.a2018.0064
·
Pubmed: 29924378

open access

Ahead of print
Original articles
Published online: 2018-06-14

Abstract

Background: The plasma-derived atherogenic index (AIP) is associated with an increasing risk for cardiovascular diseases. Whether an increased AIP may predict the complexity of percutaneous coronary intervention (PCI) of chronic total occlusion (CTO), according to available research, has never been investigated before.

Methods: 317 patients were included prospectively and treated with PCI for at least one CTO between 2012 and 2017. High-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) plasma levels were measured 24 h before PCI. All patients were stratified into tertiles of AIP (defined as 0.11, 0.11–0.21, > 0.21) based on their TG/HDL-C (AIP) levels.

Results: Mean AIP of all patients undergoing CTO-PCI was 0.53 ± 0.29. The majority of patients were male (82.6%), and mean age was 61 ± 10.4 years. Increased AIP > 0.21 was associated with longer occlusion length (statistical trend p = 0.082) and stent routes (p = 0.022) and with a higher number of implanted stents (n > 4) (statistical trend p = 0.072). Success rates were similar in all AIP categories (p = 0.461). In-hospital PCI-related complications were rare and not statistically different (p = 0.852). 

Conclusions: This  study demonstrates for the first time that an increased AIP may predict the complexity of CTO-PCI and additionally may help to improve planning and quality of CTO-PCI.

Abstract

Background: The plasma-derived atherogenic index (AIP) is associated with an increasing risk for cardiovascular diseases. Whether an increased AIP may predict the complexity of percutaneous coronary intervention (PCI) of chronic total occlusion (CTO), according to available research, has never been investigated before.

Methods: 317 patients were included prospectively and treated with PCI for at least one CTO between 2012 and 2017. High-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) plasma levels were measured 24 h before PCI. All patients were stratified into tertiles of AIP (defined as 0.11, 0.11–0.21, > 0.21) based on their TG/HDL-C (AIP) levels.

Results: Mean AIP of all patients undergoing CTO-PCI was 0.53 ± 0.29. The majority of patients were male (82.6%), and mean age was 61 ± 10.4 years. Increased AIP > 0.21 was associated with longer occlusion length (statistical trend p = 0.082) and stent routes (p = 0.022) and with a higher number of implanted stents (n > 4) (statistical trend p = 0.072). Success rates were similar in all AIP categories (p = 0.461). In-hospital PCI-related complications were rare and not statistically different (p = 0.852). 

Conclusions: This  study demonstrates for the first time that an increased AIP may predict the complexity of CTO-PCI and additionally may help to improve planning and quality of CTO-PCI.

Get Citation

Keywords

atherogenic index, chronic total occlusion (CTO), coronary artery disease, percutaneous coronary intervention (PCI)

About this article
Title

The atherogenic index of plasma and its impact on recanalization of chronic total occlusion

Journal

Cardiology Journal

Issue

Ahead of print

Article type

Original Article

Published online

2018-06-14

DOI

10.5603/CJ.a2018.0064

Pubmed

29924378

Keywords

atherogenic index
chronic total occlusion (CTO)
coronary artery disease
percutaneous coronary intervention (PCI)

Authors

Jan-Erik Guelker
Alexander Bufe
Christian Blockhaus
Knut Kroeger
Thomas Rock
Ibrahim Akin
Michael Behnes
Kambis Mashayekhi

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