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Vol 27, No 4 (2020)
Original articles — Clinical cardiology
Published online: 2018-09-07
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Prognostic significance of red cell distribution width and its relation to increased pulmonary pressure and inflammation in acute heart failure

Ryszard Targoński, Janusz Sadowski, Magdalena Starek-Stelmaszczyk, Radosław Targoński, Andrzej Rynkiewicz
DOI: 10.5603/CJ.a2018.0103
·
Pubmed: 30234900
·
Cardiol J 2020;27(4):394-403.

open access

Vol 27, No 4 (2020)
Original articles — Clinical cardiology
Published online: 2018-09-07

Abstract

Background: Red cell distribution width (RDW) in acute heart failure (AHF) is accepted as a prognostic indicator with unclear pathophysiological ties. The aim of this study was to evaluate the prognostic value of RDW in AHF patients in relation to clinical and echocardiographic data.
Methods: 170 patients with AHF were retrospectively studied. All patients had laboratory testing and an echocardiogram performed within 24 h of admission to the Cardiology Department.
Results: During the mean 193 ± 111 days of follow-up, 33 patients died. More advanced age, high RDW and low peak early diastolic velocity of the lateral mitral annulus (MVe’) were independent predictors of all-cause mortality with hazard ratios of: 1.05 (95% CI 1.02–1.09), p < 0.005, 1.40 (95% CI 1.22–1.60), p < 0.001, and 0.77 (95% CI 0.63–0.93), p < 0.007, respectively. In a stepwise multiple linear regression model, RDW was correlated with hemoglobin concentration (standardized b = –0.233, p < 0.001), mean corpuscular volum (standardized b = –0.230, p < 0.001), mean corpuscular hemoglobin concentration (standardized b = –0.207, p < 0.007), the natural logarithm of C-reactive protein (CRP) (standardized b = 0.184, p < 0.004) and tricuspid regurgitation peak gradient (TRPG) values (standardized b = 0.179, p < 0.006), whereas MVe’ was correlated with atrial fibrillation (standardized b = 0.269, p < 0.001).
Conclusions: The present data demonstrates a novel relation between higher levels of RDW and elevated
TRPG and high sensitivity CRP values in patients with AHF. These findings suggest that RDW, the most important mortality predictor, is independently associated with elevated pulmonary pressure and systemic
inflammation in patients with AHF. Moreover, in AHF patients, more advanced age and decreased MVe’ are also independently associated with total mortality risk.

Abstract

Background: Red cell distribution width (RDW) in acute heart failure (AHF) is accepted as a prognostic indicator with unclear pathophysiological ties. The aim of this study was to evaluate the prognostic value of RDW in AHF patients in relation to clinical and echocardiographic data.
Methods: 170 patients with AHF were retrospectively studied. All patients had laboratory testing and an echocardiogram performed within 24 h of admission to the Cardiology Department.
Results: During the mean 193 ± 111 days of follow-up, 33 patients died. More advanced age, high RDW and low peak early diastolic velocity of the lateral mitral annulus (MVe’) were independent predictors of all-cause mortality with hazard ratios of: 1.05 (95% CI 1.02–1.09), p < 0.005, 1.40 (95% CI 1.22–1.60), p < 0.001, and 0.77 (95% CI 0.63–0.93), p < 0.007, respectively. In a stepwise multiple linear regression model, RDW was correlated with hemoglobin concentration (standardized b = –0.233, p < 0.001), mean corpuscular volum (standardized b = –0.230, p < 0.001), mean corpuscular hemoglobin concentration (standardized b = –0.207, p < 0.007), the natural logarithm of C-reactive protein (CRP) (standardized b = 0.184, p < 0.004) and tricuspid regurgitation peak gradient (TRPG) values (standardized b = 0.179, p < 0.006), whereas MVe’ was correlated with atrial fibrillation (standardized b = 0.269, p < 0.001).
Conclusions: The present data demonstrates a novel relation between higher levels of RDW and elevated
TRPG and high sensitivity CRP values in patients with AHF. These findings suggest that RDW, the most important mortality predictor, is independently associated with elevated pulmonary pressure and systemic
inflammation in patients with AHF. Moreover, in AHF patients, more advanced age and decreased MVe’ are also independently associated with total mortality risk.

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Keywords

acute heart failure, red cell distribution width, anemia, MVe’, tricuspid regurgitation peak gradient, high sensitivity C-reactive protein

About this article
Title

Prognostic significance of red cell distribution width and its relation to increased pulmonary pressure and inflammation in acute heart failure

Journal

Cardiology Journal

Issue

Vol 27, No 4 (2020)

Pages

394-403

Published online

2018-09-07

DOI

10.5603/CJ.a2018.0103

Pubmed

30234900

Bibliographic record

Cardiol J 2020;27(4):394-403.

Keywords

acute heart failure
red cell distribution width
anemia
MVe’
tricuspid regurgitation peak gradient
high sensitivity C-reactive protein

Authors

Ryszard Targoński
Janusz Sadowski
Magdalena Starek-Stelmaszczyk
Radosław Targoński
Andrzej Rynkiewicz

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