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Comparison of short-term clinical outcomes between Resolute Onyx zotarolimus-eluting stents and everolimus-eluting stent in patients with acute myocardial infarction: Results from the Korea Acute Myocardial infarction Registry (KAMIR)

Yongcheol Kim, Sung Sik Oh, Myung Ho Jeong, Youngkeun Ahn, Ju han Kim, Young Joon Hong, Doo Sun Sim, Min Chul Kim, Hyo-Soo Kim, Kyeong Ho Yun, Seok Kyu Oh, Chong Jin Kim, Myeong Chan Cho
DOI: 10.5603/CJ.a2018.0053
·
Pubmed: 29745969

open access

Ahead of print
Original articles
Published online: 2018-05-08

Abstract

Background: There are few studies which compare the efficacy and safety of the Resolute Onyx zotarolimus-eluting stent (O-ZES) and everolimus-eluting stent (EES) in patients with acute myocardial infarction (AMI). Therefore, the present study aimed to compare clinical outcomes of O-ZES and EES in patients with AMI undergoing successful percutaneous coronary intervention (PCI).

Methods: From January 2016 to December 2016, the Korea Acute Myocardial Infarction Registry (KAMIR) enrolled 3,364 consecutive patients. Among them, O-ZES was used in 402 patients and EES was used in 1,084 patients. The primary endpoint was target lesion failure (TLF), as defined by  composite of cardiac death, target vessel myocardial infarction (TV-MI), and ischemic driven-target lesion revascularization (ID-TLR) at six month clinical follow-up.

Results: At 6 months, the incidence of TLF was not significantly different between O-ZES and EES group (4.0% vs. 3.9%, adjusted hazard ratio [HR] 1.36, 95% confidential interval [CI] 0.67–2.77, p = 0.930). O-ZES also showed similar results of cardiac death (3.7% vs. 3.4%, adjusted HR 1.38, 95% CI 0.65–2.93, p = 0.771), TV-MI (0.2% vs. 0.6%, adjusted HR 0.86, 95% CI 0.09–7.90, p = 0.456), ID-TLR (0.0% vs. 0.3%, p = 0.524), and definite or probable stent thrombosis (0.2% vs. 0.3%, adjusted HR 1.71, 95% CI 0.06–46.09, p = 0.938) when compared with EES.

Conclusions: The present study shows that implantation of O-ZES or EES provided similar clinical outcomes with similar risk at 6-month of TLF and definite/probable ST in patients with AMI undergoing successful PCI.

Abstract

Background: There are few studies which compare the efficacy and safety of the Resolute Onyx zotarolimus-eluting stent (O-ZES) and everolimus-eluting stent (EES) in patients with acute myocardial infarction (AMI). Therefore, the present study aimed to compare clinical outcomes of O-ZES and EES in patients with AMI undergoing successful percutaneous coronary intervention (PCI).

Methods: From January 2016 to December 2016, the Korea Acute Myocardial Infarction Registry (KAMIR) enrolled 3,364 consecutive patients. Among them, O-ZES was used in 402 patients and EES was used in 1,084 patients. The primary endpoint was target lesion failure (TLF), as defined by  composite of cardiac death, target vessel myocardial infarction (TV-MI), and ischemic driven-target lesion revascularization (ID-TLR) at six month clinical follow-up.

Results: At 6 months, the incidence of TLF was not significantly different between O-ZES and EES group (4.0% vs. 3.9%, adjusted hazard ratio [HR] 1.36, 95% confidential interval [CI] 0.67–2.77, p = 0.930). O-ZES also showed similar results of cardiac death (3.7% vs. 3.4%, adjusted HR 1.38, 95% CI 0.65–2.93, p = 0.771), TV-MI (0.2% vs. 0.6%, adjusted HR 0.86, 95% CI 0.09–7.90, p = 0.456), ID-TLR (0.0% vs. 0.3%, p = 0.524), and definite or probable stent thrombosis (0.2% vs. 0.3%, adjusted HR 1.71, 95% CI 0.06–46.09, p = 0.938) when compared with EES.

Conclusions: The present study shows that implantation of O-ZES or EES provided similar clinical outcomes with similar risk at 6-month of TLF and definite/probable ST in patients with AMI undergoing successful PCI.

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Keywords

drug-eluting stents, myocardial infarction, percutaneous coronary intervention

About this article
Title

Comparison of short-term clinical outcomes between Resolute Onyx zotarolimus-eluting stents and everolimus-eluting stent in patients with acute myocardial infarction: Results from the Korea Acute Myocardial infarction Registry (KAMIR)

Journal

Cardiology Journal

Issue

Ahead of print

Published online

2018-05-08

DOI

10.5603/CJ.a2018.0053

Pubmed

29745969

Keywords

drug-eluting stents
myocardial infarction
percutaneous coronary intervention

Authors

Yongcheol Kim
Sung Sik Oh
Myung Ho Jeong
Youngkeun Ahn
Ju han Kim
Young Joon Hong
Doo Sun Sim
Min Chul Kim
Hyo-Soo Kim
Kyeong Ho Yun
Seok Kyu Oh
Chong Jin Kim
Myeong Chan Cho

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