open access

Vol 26, No 4 (2019)
Original articles — Basic science and experimental cardiology
Published online: 2018-03-26
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Increased plasma cathepsin S and trombospondin-1 in patients with acute ST-segment elevation myocardial infarction

Rahel Befekadu, Kjeld Christiansen, Anders Larsson, Magnus Grenegård
DOI: 10.5603/CJ.a2018.0030
·
Pubmed: 29611169
·
Cardiol J 2019;26(4):385-393.

open access

Vol 26, No 4 (2019)
Original articles — Basic science and experimental cardiology
Published online: 2018-03-26

Abstract

Background: The role of cathepsins in the pathological progression of atherosclerotic lesions in ischem­ic heart disease have been defined in detail more than numerous times. This investigation examined the platelet-specific biomarker trombospondin-1 (TSP-1) and platelet function ex vivo, and compared this with cathepsin S (Cat-S; a biomarker unrelated to platelet activation but also associated this with increased mortality risk) in patients with ST-segment elevation myocardial infarction (STEMI).

Methods: The STEMI patients were divided into two groups depending on the degree of coronary vessel occlusion: those with closed (n = 90) and open culprit vessel (n = 40). Cat-S and TSP-1 were analyzed before, 1–3 days after and 3 months after percutanous coronary intervention (PCI).

Results: During acute STEMI, plasma TSP-1 was significantly elevated in patients with closed cul­prit lesions, but rapidly declined after PCI. In fact, TSP-1 after PCI was significantly lower inpatient samples compared to healthy individuals. In comparison, plasma Cat-S was significantly elevated both before and after PCI. In patients with closed culprit lesions, Cat-S was significantly higher compared to patients with open culprit lesions 3 months after PCI. Although troponin-I were higher (p < 0.01) in patients with closed culprit lesion, there was no correlation with Cat-S and TSP-1.

Conclusions: Cat-S but not TSP-1 may be a useful risk biomarker in relation to the severity of STEMI. However, the causality of Cat-S as a predictor for long-term mortality in STEMI remains to be ascertained in future studies.

Abstract

Background: The role of cathepsins in the pathological progression of atherosclerotic lesions in ischem­ic heart disease have been defined in detail more than numerous times. This investigation examined the platelet-specific biomarker trombospondin-1 (TSP-1) and platelet function ex vivo, and compared this with cathepsin S (Cat-S; a biomarker unrelated to platelet activation but also associated this with increased mortality risk) in patients with ST-segment elevation myocardial infarction (STEMI).

Methods: The STEMI patients were divided into two groups depending on the degree of coronary vessel occlusion: those with closed (n = 90) and open culprit vessel (n = 40). Cat-S and TSP-1 were analyzed before, 1–3 days after and 3 months after percutanous coronary intervention (PCI).

Results: During acute STEMI, plasma TSP-1 was significantly elevated in patients with closed cul­prit lesions, but rapidly declined after PCI. In fact, TSP-1 after PCI was significantly lower inpatient samples compared to healthy individuals. In comparison, plasma Cat-S was significantly elevated both before and after PCI. In patients with closed culprit lesions, Cat-S was significantly higher compared to patients with open culprit lesions 3 months after PCI. Although troponin-I were higher (p < 0.01) in patients with closed culprit lesion, there was no correlation with Cat-S and TSP-1.

Conclusions: Cat-S but not TSP-1 may be a useful risk biomarker in relation to the severity of STEMI. However, the causality of Cat-S as a predictor for long-term mortality in STEMI remains to be ascertained in future studies.

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Keywords

ST-segment elevation myocardial infarction; cathepsin S; percutaneous coronary intervention; platelets

About this article
Title

Increased plasma cathepsin S and trombospondin-1 in patients with acute ST-segment elevation myocardial infarction

Journal

Cardiology Journal

Issue

Vol 26, No 4 (2019)

Pages

385-393

Published online

2018-03-26

DOI

10.5603/CJ.a2018.0030

Pubmed

29611169

Bibliographic record

Cardiol J 2019;26(4):385-393.

Keywords

ST-segment elevation myocardial infarction
cathepsin S
percutaneous coronary intervention
platelets

Authors

Rahel Befekadu
Kjeld Christiansen
Anders Larsson
Magnus Grenegård

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