open access

Vol 25, No 6 (2018)
Review articles — Basic science and experimental cardiology
Published online: 2017-12-14
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Non-coding RNAs in cardiac fibrosis: Emerging biomarkers and therapeutic targets

Zhongxiu Chen, Chen Li, Ke Lin, Huawei Cai, Weiqiang Ruan, Junyang Han, Li Rao
DOI: 10.5603/CJ.a2017.0153
·
Pubmed: 29240957
·
Cardiol J 2018;25(6):732-741.

open access

Vol 25, No 6 (2018)
Review articles — Basic science and experimental cardiology
Published online: 2017-12-14

Abstract

Non-coding RNAs (ncRNAs) are a class of RNA molecules that do not encode proteins. ncRNAs are involved in cell proliferation, apoptosis, differentiation, metabolism, and other physiological processes as well as the pathogenesis of diseases. Cardiac fibrosis is increasingly recognized as a common final pathway in advanced heart diseases. Many studies have shown that the occurrence and development of cardiac fibrosis is closely related to the regulation of ncRNAs. This review will highlight recent updates regarding the involvement of ncRNAs in cardiac fibrosis, and their potential as emerging biomarkers and therapeutic targets.

Abstract

Non-coding RNAs (ncRNAs) are a class of RNA molecules that do not encode proteins. ncRNAs are involved in cell proliferation, apoptosis, differentiation, metabolism, and other physiological processes as well as the pathogenesis of diseases. Cardiac fibrosis is increasingly recognized as a common final pathway in advanced heart diseases. Many studies have shown that the occurrence and development of cardiac fibrosis is closely related to the regulation of ncRNAs. This review will highlight recent updates regarding the involvement of ncRNAs in cardiac fibrosis, and their potential as emerging biomarkers and therapeutic targets.

Get Citation

Keywords

cardiac fibrosis, ncRNAs; biomarkers, therapeutic targets

About this article
Title

Non-coding RNAs in cardiac fibrosis: Emerging biomarkers and therapeutic targets

Journal

Cardiology Journal

Issue

Vol 25, No 6 (2018)

Pages

732-741

Published online

2017-12-14

DOI

10.5603/CJ.a2017.0153

Pubmed

29240957

Bibliographic record

Cardiol J 2018;25(6):732-741.

Keywords

cardiac fibrosis
ncRNAs
biomarkers
therapeutic targets

Authors

Zhongxiu Chen
Chen Li
Ke Lin
Huawei Cai
Weiqiang Ruan
Junyang Han
Li Rao

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