open access

Vol 25, No 4 (2018)
Original articles — Clinical cardiology
Published online: 2017-11-17
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Anxiety disorders and stressful events in Takotsubo syndrome

Davide Lazzeroni, Matteo Bini, Paolo Castiglioni, Luca Moderato, Chiara Ciracì, Umberto Camaiora, Pietro Tito Ugolotti, Lorenzo Brambilla, Valerio Brambilla, Silvia Garibaldi, Letizia Paglialonga, Valentina Ziveri, Fabrizio Ugo, Nicola Gaibazzi, Paolo Coruzzi
DOI: 10.5603/CJ.a2017.0136
·
Pubmed: 29168538
·
Cardiol J 2018;25(4):495-500.

open access

Vol 25, No 4 (2018)
Original articles — Clinical cardiology
Published online: 2017-11-17

Abstract

Background: Anxiety disorders are more common in Takotsubo syndrome (TS) than in acute coronary syndrome patients. The aim of this study was to investigate whether pre-existing anxiety disorders predispose to TS triggered by exclusively emotional stressful events.
Methods: Triggering events were compared in 58 TS patients with and without pre-existing anxiety disorders; clinical, electrocardiographic and echocardiographic data were also collected.
Results: Thirty-one (53%) patients had a previous history of anxiety disorders. The exclusively emotional stressful event-rate was higher in TS patients with pre-existing anxiety disorder (74% vs. 30%, p = 0.001), while TS caused by an undetermined trigger were significantly higher in patients without anxiety disorders (33% vs. 10%, p = 0.027). Moreover, in TS patients without a previous history of anxiety disorders, a trend of higher prevalence of physical events was found (16% vs. 37%, p = 0.07).
Conclusions: In patients with pre-existing anxiety disorders, TS was predominantly triggered by exclusively emotional stressful events, thereby suggesting a possible relationship between anxiety and emotional cardiac frailty in TS patients.

Abstract

Background: Anxiety disorders are more common in Takotsubo syndrome (TS) than in acute coronary syndrome patients. The aim of this study was to investigate whether pre-existing anxiety disorders predispose to TS triggered by exclusively emotional stressful events.
Methods: Triggering events were compared in 58 TS patients with and without pre-existing anxiety disorders; clinical, electrocardiographic and echocardiographic data were also collected.
Results: Thirty-one (53%) patients had a previous history of anxiety disorders. The exclusively emotional stressful event-rate was higher in TS patients with pre-existing anxiety disorder (74% vs. 30%, p = 0.001), while TS caused by an undetermined trigger were significantly higher in patients without anxiety disorders (33% vs. 10%, p = 0.027). Moreover, in TS patients without a previous history of anxiety disorders, a trend of higher prevalence of physical events was found (16% vs. 37%, p = 0.07).
Conclusions: In patients with pre-existing anxiety disorders, TS was predominantly triggered by exclusively emotional stressful events, thereby suggesting a possible relationship between anxiety and emotional cardiac frailty in TS patients.

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Keywords

Takotsubo syndrome; anxiety disorders; stressful events; stress cardiomyopathy; psychiatric disorders

About this article
Title

Anxiety disorders and stressful events in Takotsubo syndrome

Journal

Cardiology Journal

Issue

Vol 25, No 4 (2018)

Pages

495-500

Published online

2017-11-17

DOI

10.5603/CJ.a2017.0136

Pubmed

29168538

Bibliographic record

Cardiol J 2018;25(4):495-500.

Keywords

Takotsubo syndrome
anxiety disorders
stressful events
stress cardiomyopathy
psychiatric disorders

Authors

Davide Lazzeroni
Matteo Bini
Paolo Castiglioni
Luca Moderato
Chiara Ciracì
Umberto Camaiora
Pietro Tito Ugolotti
Lorenzo Brambilla
Valerio Brambilla
Silvia Garibaldi
Letizia Paglialonga
Valentina Ziveri
Fabrizio Ugo
Nicola Gaibazzi
Paolo Coruzzi

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