Vol 24, No 4 (2017)
Review articles — Interventional cardiology
Published online: 2017-06-20

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Fractional flow reserve (FFR)-based therapy in patients presenting with acute coronary syndrome: Current data and everyday practice

Grzegorz Zuk1, Dariusz Ciecwierz1, Natalia Cwalina1, Marcin Gruchala1, Florim Cuculi2
Pubmed: 28653314
Cardiol J 2017;24(4):426-435.


Fractional flow reserve (FFR) is an evidence-based diagnostic tool of physiological significance of coronary artery stenosis in patients with stable coronary artery disease (CAD). Due to microvascular dysfunction in acute coronary syndrome (ACS), information obtained from FFR assessment could be less reliable and, thus, its clinical role remains controversial. Indeed, results of currently published studies are essentially discrepant. Only a few randomized clinical trials have been performed showing the efficacy of FFR-guided percutaneous coronary intervention in ACS. Consequently, its role in acute scenarios remains substantially understudied. Herein, is presented the current state of knowledge re­garding FFR use in ACS setting. (Cardiol J 2017; 24, 4: 426–435)

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