open access

Vol 25, No 6 (2018)
Original articles — Interventional cardiology
Published online: 2017-07-14
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Different postconditioning cycles affect prognosis of aged patients undergoing primary percutaneous coronary intervention

Jie Zhang, Xin Zhang, Yuqi Cui, Misbahul Ferdous, Lianqun Cui, Peng Zhao
DOI: 10.5603/CJ.a2017.0083
·
Pubmed: 28714526
·
Cardiol J 2018;25(6):666-673.

open access

Vol 25, No 6 (2018)
Original articles — Interventional cardiology
Published online: 2017-07-14

Abstract

Background: Postconditioning can affect the infarct size in acute myocardial infarction (AMI). How­ever, few studies show an effect of different postconditioning cycles on AMI aged patients. This study sought to assess the effect of different postconditioning cycles on prognosis in aged patients with AMI who underwent primary percutaneous coronary intervention (PCI).

Methods: Seventy four aged patients were randomly assigned to three groups. Control group; PC-1 group accepted postconditioning 4 cycles of 30 s inflation and 30 s deflation; PC-2 group accepted postconditioning 4 cycles of 60 s. Creatine kinase MB (CK-MB), troponin I (cTnI), high-sensitive C-reactive protein (hs-CRP) and corrected Thrombolysis in Myocardial Infarction (TIMI) frame counts (CTFC) were analyzed before and after treatment. All patients received an echocardiographic examina­tion for whole heart function, wall motion score index (WMSI) and single-photon emission computed tomography (SPECT) examination at 7 days and 6 months after treatment.

Results: The peak of CK-MB, postoperative 72 h cTnI and CTFC were significantly attenuated by postconditioning when compared with the control group. The hs-CRP of the postconditioning group was lower than the control group 24 h postoperative. No difference was observed between PC-1 and PC-2 group about the effect described above. At 7 days, heart function in the postconditioning group was im­proved when compared with the control group. At 6 months, the WMSI and SPECT score significantly reduced in the PC-2 group compared with the control and PC-1 groups, but there was no difference among the three groups about echo data except the left ventricular end-systolic diameter.

Conclusions: Postconditioning is significantly beneficial to prognosis in aged patients with AMI. The cardiac protective effect of 4 cycles of 60 s procedure was observed in WMSI and SPECT. It is favorable to implement this procedure in aged patients with AMI in clinic.

Abstract

Background: Postconditioning can affect the infarct size in acute myocardial infarction (AMI). How­ever, few studies show an effect of different postconditioning cycles on AMI aged patients. This study sought to assess the effect of different postconditioning cycles on prognosis in aged patients with AMI who underwent primary percutaneous coronary intervention (PCI).

Methods: Seventy four aged patients were randomly assigned to three groups. Control group; PC-1 group accepted postconditioning 4 cycles of 30 s inflation and 30 s deflation; PC-2 group accepted postconditioning 4 cycles of 60 s. Creatine kinase MB (CK-MB), troponin I (cTnI), high-sensitive C-reactive protein (hs-CRP) and corrected Thrombolysis in Myocardial Infarction (TIMI) frame counts (CTFC) were analyzed before and after treatment. All patients received an echocardiographic examina­tion for whole heart function, wall motion score index (WMSI) and single-photon emission computed tomography (SPECT) examination at 7 days and 6 months after treatment.

Results: The peak of CK-MB, postoperative 72 h cTnI and CTFC were significantly attenuated by postconditioning when compared with the control group. The hs-CRP of the postconditioning group was lower than the control group 24 h postoperative. No difference was observed between PC-1 and PC-2 group about the effect described above. At 7 days, heart function in the postconditioning group was im­proved when compared with the control group. At 6 months, the WMSI and SPECT score significantly reduced in the PC-2 group compared with the control and PC-1 groups, but there was no difference among the three groups about echo data except the left ventricular end-systolic diameter.

Conclusions: Postconditioning is significantly beneficial to prognosis in aged patients with AMI. The cardiac protective effect of 4 cycles of 60 s procedure was observed in WMSI and SPECT. It is favorable to implement this procedure in aged patients with AMI in clinic.

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Keywords

aged, acute myocardial infarction, primary percutaneous coronary intervention, postconditioning cycles

About this article
Title

Different postconditioning cycles affect prognosis of aged patients undergoing primary percutaneous coronary intervention

Journal

Cardiology Journal

Issue

Vol 25, No 6 (2018)

Pages

666-673

Published online

2017-07-14

DOI

10.5603/CJ.a2017.0083

Pubmed

28714526

Bibliographic record

Cardiol J 2018;25(6):666-673.

Keywords

aged
acute myocardial infarction
primary percutaneous coronary intervention
postconditioning cycles

Authors

Jie Zhang
Xin Zhang
Yuqi Cui
Misbahul Ferdous
Lianqun Cui
Peng Zhao

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