open access

Vol 26, No 5 (2019)
Original articles — Clinical cardiology
Published online: 2017-10-18
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Morning and afternoon serum cortisol level in patients with post-myocardial infarction depression

Alina Wilkowska, Andrzej Rynkiewicz, Joanna Wdowczyk, Jerzy Landowski
DOI: 10.5603/CJ.a2017.0123
·
Pubmed: 29064538
·
Cardiol J 2019;26(5):550-554.

open access

Vol 26, No 5 (2019)
Original articles — Clinical cardiology
Published online: 2017-10-18

Abstract

Background: Post-myocardial depression is a highly prevalent condition which worsens the course and prognosis of coronary artery disease. One possible pathogenetic factor is dysregulation of the hypothalamic-pituitary-adrenal axis, resulting in cortisol profile disturbances. Methods: Thirty seven patients hospitalized due to a first myocardial infarction (MI) were enrolled in this study. The Beck Depression Inventory (BDI) was used to rate the severity of their depressive symptoms. Morning and afternoon serum cortisol samples were taken on the fifth day of the MI. Results: Depression, defined as BDI ≥ 10, was present in 34.4% of the patients. A statistically significant difference was observed between the mean morning and the evening plasma concentrations in patients with depression compared to the no-depression group: F (1.29) = 5.0405, p = 0.0328. Conclusions: Patients with depressive symptoms directly after MI have a flattened diurnal serum cortisol profile. This is particularly expressed in patients with longer lasting symptoms.

Abstract

Background: Post-myocardial depression is a highly prevalent condition which worsens the course and prognosis of coronary artery disease. One possible pathogenetic factor is dysregulation of the hypothalamic-pituitary-adrenal axis, resulting in cortisol profile disturbances. Methods: Thirty seven patients hospitalized due to a first myocardial infarction (MI) were enrolled in this study. The Beck Depression Inventory (BDI) was used to rate the severity of their depressive symptoms. Morning and afternoon serum cortisol samples were taken on the fifth day of the MI. Results: Depression, defined as BDI ≥ 10, was present in 34.4% of the patients. A statistically significant difference was observed between the mean morning and the evening plasma concentrations in patients with depression compared to the no-depression group: F (1.29) = 5.0405, p = 0.0328. Conclusions: Patients with depressive symptoms directly after MI have a flattened diurnal serum cortisol profile. This is particularly expressed in patients with longer lasting symptoms.

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Keywords

depression; myocardial infarction; cortisol; hypothalamic pituitary adrenal axis

About this article
Title

Morning and afternoon serum cortisol level in patients with post-myocardial infarction depression

Journal

Cardiology Journal

Issue

Vol 26, No 5 (2019)

Pages

550-554

Published online

2017-10-18

DOI

10.5603/CJ.a2017.0123

Pubmed

29064538

Bibliographic record

Cardiol J 2019;26(5):550-554.

Keywords

depression
myocardial infarction
cortisol
hypothalamic pituitary adrenal axis

Authors

Alina Wilkowska
Andrzej Rynkiewicz
Joanna Wdowczyk
Jerzy Landowski

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