open access

Vol 24, No 4 (2017)
Original articles — Clinical cardiology
Published online: 2017-01-11
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Muscle strength and carotid artery flow velocity is associated with increased risk of atherosclerosis in adults

Jinkee Park, Hyuntae Park
DOI: 10.5603/CJ.a2017.0007
·
Pubmed: 28150294
·
Cardiol J 2017;24(4):385-392.

open access

Vol 24, No 4 (2017)
Original articles — Clinical cardiology
Published online: 2017-01-11

Abstract

Background: Carotid intima–media thickness (CIMT) has been proposed as a surrogate marker of atherosclerotic disease. In addition, carotid flow velocity (FV) and muscle strength (MS) are reported to be associated with increased CIMT. As there remains insufficient evidence for a complex association of CIMT with FV and MS, the aim of this study was to examine this association in adults.

Methods: A total of 426 adults participated in this study. MS in all subjects was measured by hand grip strength. Carotid variables were measured with B-mode ultrasound. Analysis of covariance (ANCOVA) was performed to assess independent differences in the CIMT among four groups, according to the level of peak systolic flow velocity (PSV) and MS after multivariate adjustment. Logistic regression analysis was performed to calculate odds ratios (OR) and 95% confidence intervals (CI) for the independent as­sociations between PSV and MS and the estimated risk of atherosclerosis.

Results: Increased CIMT is associated with MS and PSV. ANCOVA showed that the CIMT varied significantly among groups according to the level of PSV and MS after multivariate adjustment. When calculated for the estimated risk of carotid atherosclerosis, the adjusted OR for the low PSV and MS group was 3.87 (95% CI 1.78–8.44).

Conclusions: The results suggest that CIMT and risk of carotid atherosclerosis are significantly cor­related with PSV and upper body MS, more closely for the PSV than for the MS after adjustment for po­tential confounders. PSV by itself, and/or PSV with grip strength may be an indicator of atherosclerotic plaque instability. (Cardiol J 2017; 24, 4: 385–392)

Abstract

Background: Carotid intima–media thickness (CIMT) has been proposed as a surrogate marker of atherosclerotic disease. In addition, carotid flow velocity (FV) and muscle strength (MS) are reported to be associated with increased CIMT. As there remains insufficient evidence for a complex association of CIMT with FV and MS, the aim of this study was to examine this association in adults.

Methods: A total of 426 adults participated in this study. MS in all subjects was measured by hand grip strength. Carotid variables were measured with B-mode ultrasound. Analysis of covariance (ANCOVA) was performed to assess independent differences in the CIMT among four groups, according to the level of peak systolic flow velocity (PSV) and MS after multivariate adjustment. Logistic regression analysis was performed to calculate odds ratios (OR) and 95% confidence intervals (CI) for the independent as­sociations between PSV and MS and the estimated risk of atherosclerosis.

Results: Increased CIMT is associated with MS and PSV. ANCOVA showed that the CIMT varied significantly among groups according to the level of PSV and MS after multivariate adjustment. When calculated for the estimated risk of carotid atherosclerosis, the adjusted OR for the low PSV and MS group was 3.87 (95% CI 1.78–8.44).

Conclusions: The results suggest that CIMT and risk of carotid atherosclerosis are significantly cor­related with PSV and upper body MS, more closely for the PSV than for the MS after adjustment for po­tential confounders. PSV by itself, and/or PSV with grip strength may be an indicator of atherosclerotic plaque instability. (Cardiol J 2017; 24, 4: 385–392)

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Keywords

carotid intima–media thickness, carotid flow velocity, muscle strength, atherosclerosis, adults

About this article
Title

Muscle strength and carotid artery flow velocity is associated with increased risk of atherosclerosis in adults

Journal

Cardiology Journal

Issue

Vol 24, No 4 (2017)

Pages

385-392

Published online

2017-01-11

DOI

10.5603/CJ.a2017.0007

Pubmed

28150294

Bibliographic record

Cardiol J 2017;24(4):385-392.

Keywords

carotid intima–media thickness
carotid flow velocity
muscle strength
atherosclerosis
adults

Authors

Jinkee Park
Hyuntae Park

References (39)
  1. Kablak-Ziembicka A, Przewlocki T, Tracz W, et al. Gender differences in carotid intima-media thickness in patients with suspected coronary artery disease. Am J Cardiol. 2005; 96(9): 1217–1222.
  2. O'Leary DH, Polak JF, Kronmal RA, et al. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med. 1999; 340(1): 14–22.
  3. Chambless LE, Folsom AR, Clegg LX, et al. Carotid wall thickness is predictive of incident clinical stroke: the Atherosclerosis Risk in Communities (ARIC) study. Am J Epidemiol. 2000; 151(5): 478–487.
  4. Murakami S, Otsuka K, Hotta N, et al. Common carotid intima-media thickness is predictive of all-cause and cardiovascular mortality in elderly community-dwelling people: Longitudinal Investigation for the Longevity and Aging in Hokkaido County (LILAC) study. Biomed Pharmacother. 2005; 59 Suppl 1: S49–S53.
  5. Takato T, Yamada N, Ashida T. Effects of aging and sex on progression of carotid intima-media thickness: a retrospective 6-year follow-up study. Geriatr Gerontol Int. 2008; 8(3): 172–179.
  6. Czernichow S, Bertrais S, Oppert JM, et al. Body composition and fat repartition in relation to structure and function of large arteries in middle-aged adults (the SU.VI.MAX study). Int J Obes (Lond). 2005; 29(7): 826–832.
  7. Pasha SM, Wiria AE, Wammes LJ, et al. Blood pressure class and carotid artery intima-media thickness in a population at the secondary epidemiological transition. J Hypertens. 2011; 29(11): 2194–2200.
  8. Beck JD, Elter JR, Heiss G, et al. Relationship of periodontal disease to carotid artery intima-media wall thickness: the atherosclerosis risk in communities (ARIC) study. Arterioscler Thromb Vasc Biol. 2001; 21(11): 1816–1822.
  9. Gando Y, Yamamoto K, Kawano H, et al. Attenuated age-related carotid arterial remodeling in adults with a high level of cardiorespiratory fitness. Med Sci Sport Exer. 2011; 43: 735–735.
  10. Lakka TA, Laukkanen JA, Rauramaa R, et al. Cardiorespiratory fitness and the progression of carotid atherosclerosis in middle-aged men. Ann Intern Med. 2001; 134(1): 12–20.
  11. Chuang SY, Bai CH, Chen JR, et al. Common carotid end-diastolic velocity and intima-media thickness jointly predict ischemic stroke in Taiwan. Stroke. 2011; 42(5): 1338–1344.
  12. Chuang SY, Bai CH, Cheng HM, et al. Common carotid artery end-diastolic velocity is independently associated with future cardiovascular events. Eur J Prev Cardiol. 2016; 23(2): 116–124.
  13. Melo X, Santa-Clara H, Santos DA, et al. Independent Association of Muscular Strength and Carotid Intima-Media Thickness in Children. Int J Sports Med. 2015; 36(8): 624–630.
  14. Bai CH, Chen JR, Chiu HC, et al. Lower blood flow velocity, higher resistance index, and larger diameter of extracranial carotid arteries are associated with ischemic stroke independently of carotid atherosclerosis and cardiovascular risk factors. J Clin Ultrasound. 2007; 35(6): 322–330.
  15. Bellinazzi VR, Cipolli JA, Pimenta MV, et al. Carotid flow velocity/diameter ratio is a predictor of cardiovascular events in hypertensive patients. J Hypertens. 2015; 33(10): 2054–2060.
  16. Silventoinen K, Magnusson PKE, Tynelius P, et al. Association of body size and muscle strength with incidence of coronary heart disease and cerebrovascular diseases: a population-based cohort study of one million Swedish men. Int J Epidemiol. 2009; 38(1): 110–118.
  17. Sasaki H, Kasagi F, Yamada M, et al. Grip strength predicts cause-specific mortality in middle-aged and elderly persons. Am J Med. 2007; 120(4): 337–342.
  18. Rantanen T, Volpato S, Ferrucci L, et al. Handgrip strength and cause-specific and total mortality in older disabled women: exploring the mechanism. J Am Geriatr Soc. 2003; 51(5): 636–641.
  19. Ling CHY, Taekema D, de Craen AJM, et al. Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study. CMAJ. 2010; 182(5): 429–435.
  20. Fitch KV, Looby SE, Rope A, et al. Effects of aging and smoking on carotid intima-media thickness in HIV-infection. AIDS. 2013; 27(1): 49–57.
  21. Scuteri A, Orru' M, Morrell CH, et al. Associations of large artery structure and function with adiposity: effects of age, gender, and hypertension. The SardiNIA Study. Atherosclerosis. 2012; 221(1): 189–197.
  22. Martiniuk A, Woodward M, Ueshima H, et al. Hypertension: Its prevalence and population attributable fraction for mortality from cardiovascular disease in the Asia-pacific region. J Hypertens. 2006; 24: 35–36.
  23. Schott LL, Kao AH, Cunningham A, et al. Do carotid artery diameters manifest early evidence of atherosclerosis in women with rheumatoid arthritis? J Womens Health (Larchmt). 2009; 18(1): 21–29.
  24. Sun Yu, Lin CH, Lu CJ, et al. Carotid atherosclerosis, intima media thickness and risk factors--an analysis of 1781 asymptomatic subjects in Taiwan. Atherosclerosis. 2002; 164(1): 89–94.
  25. Mateo I, Morillas P, Quiles J, et al. What measure of carotid wall thickening is the best atherosclerotic loading score in the hypertensive patient: maximum or mean value? Rev Esp Cardiol. 2011; 64(5): 417–420.
  26. Lorenz MW, Markus HS, Bots ML, et al. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation. 2007; 115(4): 459–467.
  27. Jae SY, Carnethon MR, Heffernan KS, et al. Association between cardiorespiratory fitness and prevalence of carotid atherosclerosis among men with hypertension. Am Heart J. 2007; 153(6): 1001–1005.
  28. Bertoni AG, Whitt-Glover MC, Chung H, et al. The association between physical activity and subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis. Am J Epidemiol. 2009; 169(4): 444–454.
  29. Hamer M, Kivimaki M, Lahiri A, et al. Walking speed and subclinical atherosclerosis in healthy older adults: the Whitehall II study. Heart. 2010; 96(5): 380–384.
  30. Jurca R, Lamonte MJ, Barlow CE, et al. Associations of muscle strength and fitness with metabolic syndrome in men. Med Sci Sports Exerc. 2004; 36(8): 1301–1307.
  31. Kawamoto R, Tomita H, Ohtsuka N, et al. Metabolic syndrome, diabetes and subclinical atherosclerosis as assessed by carotid intima-media thickness. J Atheroscler Thromb. 2007; 14(2): 78–85.
  32. Abdelghaffar S, El Amir M, El Hadidi A, et al. Carotid intima-media thickness: an index for subclinical atherosclerosis in type 1 diabetes. J Trop Pediatr. 2006; 52(1): 39–45.
  33. Yasuda T, Matsuhisa M, Fujiki N, et al. Is central obesity a good predictor of carotid atherosclerosis in Japanese type 2 diabetes with metabolic syndrome? Endocr J. 2007; 54(5): 695–702.
  34. Chen W, Srinivasan SR, Xu J, et al. Effect of parental coronary artery disease on adverse effects of the metabolic syndrome and aging on carotid artery intima-media thickness (from the Bogalusa Heart Study). Am J Cardiol. 2008; 102(2): 180–183.
  35. Ren C, Zhang J, Xu Yu, et al. Association between carotid intima-media thickness and index of central fat distribution in middle-aged and elderly Chinese. Cardiovasc Diabetol. 2014; 13: 139.
  36. Kozakova M, Palombo C, Mhamdi L, et al. RISC Investigators. Habitual physical activity and vascular aging in a young to middle-age population at low cardiovascular risk. Stroke. 2007; 38(9): 2549–2555.
  37. Juonala M, Viikari JSA, Rönnemaa T, et al. Associations of dyslipidemias from childhood to adulthood with carotid intima-media thickness, elasticity, and brachial flow-mediated dilatation in adulthood: the Cardiovascular Risk in Young Finns Study. Arterioscler Thromb Vasc Biol. 2008; 28(5): 1012–1017.
  38. Lorenz MW, von Kegler S, Steinmetz H, et al. Carotid intima-media thickening indicates a higher vascular risk across a wide age range: prospective data from the Carotid Atherosclerosis Progression Study (CAPS). Stroke. 2006; 37(1): 87–92.
  39. Lorenz MW, Karbstein P, Markus HS, et al. High-sensitivity C-reactive protein is not associated with carotid intima-media progression: the carotid atherosclerosis progression study. Stroke. 2007; 38(6): 1774–1779.

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