open access

Vol 24, No 4 (2017)
Original articles — Clinical cardiology
Published online: 2017-01-11
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Erectile dysfunction as a predictor of two-year prognosis in acute myocardial infarction

Svetlana Apostolovic, Dragana Stanojevic, Ruzica Jankovic-Tomasevic, Sonja Salinger-Martinovic, Tomislav Kostic, Zoran Perisic
DOI: 10.5603/CJ.a2017.0006
·
Pubmed: 28150293
·
Cardiol J 2017;24(4):393-402.

open access

Vol 24, No 4 (2017)
Original articles — Clinical cardiology
Published online: 2017-01-11

Abstract

Background: Erectile dysfunction (ED) is a predictor or marker of coronary artery disease in patients at high risk of cardiovascular diseases. The aim of this study was to investigate the prevalence of ED in patients with acute myocardial infarction (AMI) and after 2 years of follow-up, and to determine the association between ED and the concentrations of the markers of inflammation, endothelial dysfunction and oxidative stress which were measured on the third day after hospital admission.

Methods: The study included 80 patients aged 62.25 ± 10.47 years. The primary endpoints of interest were re-hospitalization due to cardiovascular causes and death during the 2 year period after hospital­ization. The Sexual Health Inventory for Men (SHIM) was assessed at the point of hospital discharge and 24 months thereafter.

Results: 40.1% of patients had some degree of ED. The percentage of patients without ED increased (13.2%), while the percentage of patients with severe ED significantly decreased (14.7%) after 2 years. Patients with ED had significantly higher B-type natriuretic peptide (BNP) levels and decreased levels of nitric-oxide. During the 2 years of follow-up, 9 patients died (6.5% without ED, 68.6% with ED) (c2 = 7.19, p = 0.015). During the same time period, 22 (27.5%) patients were re-hospitalized due to cardiovascular causes, of whom 59.1% had ED at hospital admission (p < 0.05).

Conclusions: Low levels of nitric-oxide were the best predictors of ED during AMI and after 2 years. ED predicted the worst outcomes of AMI: death and re-hospitalization. Lifestyle changes and nitric- -oxide donors could assist in the treatment of ED and in the improvement of long-term prognosis for AMI. (Cardiol J 2017; 24, 4: 393–402)

Abstract

Background: Erectile dysfunction (ED) is a predictor or marker of coronary artery disease in patients at high risk of cardiovascular diseases. The aim of this study was to investigate the prevalence of ED in patients with acute myocardial infarction (AMI) and after 2 years of follow-up, and to determine the association between ED and the concentrations of the markers of inflammation, endothelial dysfunction and oxidative stress which were measured on the third day after hospital admission.

Methods: The study included 80 patients aged 62.25 ± 10.47 years. The primary endpoints of interest were re-hospitalization due to cardiovascular causes and death during the 2 year period after hospital­ization. The Sexual Health Inventory for Men (SHIM) was assessed at the point of hospital discharge and 24 months thereafter.

Results: 40.1% of patients had some degree of ED. The percentage of patients without ED increased (13.2%), while the percentage of patients with severe ED significantly decreased (14.7%) after 2 years. Patients with ED had significantly higher B-type natriuretic peptide (BNP) levels and decreased levels of nitric-oxide. During the 2 years of follow-up, 9 patients died (6.5% without ED, 68.6% with ED) (c2 = 7.19, p = 0.015). During the same time period, 22 (27.5%) patients were re-hospitalized due to cardiovascular causes, of whom 59.1% had ED at hospital admission (p < 0.05).

Conclusions: Low levels of nitric-oxide were the best predictors of ED during AMI and after 2 years. ED predicted the worst outcomes of AMI: death and re-hospitalization. Lifestyle changes and nitric- -oxide donors could assist in the treatment of ED and in the improvement of long-term prognosis for AMI. (Cardiol J 2017; 24, 4: 393–402)

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Keywords

erectile dysfunction, acute myocardial infarction, prognosis, biomarker, nitric-oxide, endothelin-1, oxidative stress

About this article
Title

Erectile dysfunction as a predictor of two-year prognosis in acute myocardial infarction

Journal

Cardiology Journal

Issue

Vol 24, No 4 (2017)

Pages

393-402

Published online

2017-01-11

DOI

10.5603/CJ.a2017.0006

Pubmed

28150293

Bibliographic record

Cardiol J 2017;24(4):393-402.

Keywords

erectile dysfunction
acute myocardial infarction
prognosis
biomarker
nitric-oxide
endothelin-1
oxidative stress

Authors

Svetlana Apostolovic
Dragana Stanojevic
Ruzica Jankovic-Tomasevic
Sonja Salinger-Martinovic
Tomislav Kostic
Zoran Perisic

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