open access

Vol 23, No 5 (2016)
CLINICAL CARDIOLOGY - REVIEW ARTICLE
Published online: 2016-07-20
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Medication adherence in patients after percutaneous coronary intervention due to acute myocardial infarction: From research to clinical implications

Damian Swieczkowski, Mariusz Mogielnicki, Natalia Cwalina, Grzegorz Zuk, Izabela Pisowodzka, Dariusz Ciecwierz, Marcin Gruchala, Milosz Jaguszewski
DOI: 10.5603/CJ.a2016.0048
·
Pubmed: 27439366
·
Cardiol J 2016;23(5):483-490.

open access

Vol 23, No 5 (2016)
CLINICAL CARDIOLOGY - REVIEW ARTICLE
Published online: 2016-07-20

Abstract

Adherence to medication is one of the most significant challenges of secondary prevention in patients after an acute myocardial infarction (AMI). Indeed, it has been well established that higher adherence is associated with better cardiovascular outcomes. Research pertaining to secondary prevention after AMI treated with percutaneous coronary intervention (PCI) focuses mainly on the adherence to antiplatelet therapy. Adherence levels have been found to be particularly poor and thus, insufficient with regards to prevention; with a high rate of discontinuation of therapy occurring during the 12-month follow-up. There are numerous predicting factors associated with non-adherence to antiplatelet therapy in patients after PCI. These include, but are not limited to, a lack of education on antiplatelet treatment, various comorbidities, depression, or even, unmarried status. Financial limitations of the patient also play a relevant role, however, the nature of this impediment is problematic and requires further investigation. It would seem beneficial to carry out advanced research based on a randomized and double-blind protocol, however, large-cohort, real-world observations are also essential to investigate non-adherence across a broad array of treatment settings above and beyond the scope of prospective clinical trials. Research about adherence under the context of invasive treatment of AMI has a tremendous practical impact and should be considered a matter of importance concerning both clinicians and scientists. Close collaboration between not only researchers, health practitioners, i.e. physicians and pharmacists, but also politicians, is strongly recommended to aid in designing an intervention that might improve patient adherence.

Abstract

Adherence to medication is one of the most significant challenges of secondary prevention in patients after an acute myocardial infarction (AMI). Indeed, it has been well established that higher adherence is associated with better cardiovascular outcomes. Research pertaining to secondary prevention after AMI treated with percutaneous coronary intervention (PCI) focuses mainly on the adherence to antiplatelet therapy. Adherence levels have been found to be particularly poor and thus, insufficient with regards to prevention; with a high rate of discontinuation of therapy occurring during the 12-month follow-up. There are numerous predicting factors associated with non-adherence to antiplatelet therapy in patients after PCI. These include, but are not limited to, a lack of education on antiplatelet treatment, various comorbidities, depression, or even, unmarried status. Financial limitations of the patient also play a relevant role, however, the nature of this impediment is problematic and requires further investigation. It would seem beneficial to carry out advanced research based on a randomized and double-blind protocol, however, large-cohort, real-world observations are also essential to investigate non-adherence across a broad array of treatment settings above and beyond the scope of prospective clinical trials. Research about adherence under the context of invasive treatment of AMI has a tremendous practical impact and should be considered a matter of importance concerning both clinicians and scientists. Close collaboration between not only researchers, health practitioners, i.e. physicians and pharmacists, but also politicians, is strongly recommended to aid in designing an intervention that might improve patient adherence.

Get Citation

Keywords

medication adherence, compliance, myocardial infarction, acute coronary syndrome, percutaneous coronary intervention, platelet aggregation inhibitors

About this article
Title

Medication adherence in patients after percutaneous coronary intervention due to acute myocardial infarction: From research to clinical implications

Journal

Cardiology Journal

Issue

Vol 23, No 5 (2016)

Pages

483-490

Published online

2016-07-20

DOI

10.5603/CJ.a2016.0048

Pubmed

27439366

Bibliographic record

Cardiol J 2016;23(5):483-490.

Keywords

medication adherence
compliance
myocardial infarction
acute coronary syndrome
percutaneous coronary intervention
platelet aggregation inhibitors

Authors

Damian Swieczkowski
Mariusz Mogielnicki
Natalia Cwalina
Grzegorz Zuk
Izabela Pisowodzka
Dariusz Ciecwierz
Marcin Gruchala
Milosz Jaguszewski

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