Estimation of shear stress by using a myocardial bridge-mural coronary artery simulating device
Abstract
Background: This study was aimed at developing a myocardial bridge-mural coronary artery simulative device and analyzing the relationship between shear stress on the mural coronary artery and atherosclerosis.
Methods: A myocardial bridge-mural coronary artery simulative device was used to simulate experiments in vitro. In the condition of maintaining any related parameters such as system temperature, average flow rate, and heart rate, we calculated and observed changes in proximal and distal mean values, and oscillatory value of shear stress on the mural coronary artery by regulating the compression level of the myocardial bridge to the mural coronary artery.
Results: Under 0% compression, no significant differences were observed in distal and proximal mean values and oscillatory value of the shear stress on the mural coronary artery. With the increase in the degree of compression, the mean shear stress at the distal end was greater than that at the proximal end, but the oscillatory value of the shear stress at the proximal end was greater than that at the distal end.
Conclusions: The experimental results of this study indicate that myocardial bridge compression leads to abnormal hemodynamics at the proximal end of the mural coronary artery. This abnormal phenomenon is of great significance in the study of atherosclerosis hemodynamic pathogenesis, which has potential clinical value for pathological effects and treatments of myocardial bridge
Keywords: mural coronary arterymyocardial bridgehemodynamicshear stress
References
- Balamuthusamy S, Kosla S, Benatar D, et al. Myocardial infarction in a young African-American male due to myocardial bridging. Cardiology. 2006; 105(3): 165–167.
- Yetman AT, McCrindle BW, MacDonald C, et al. Myocardial bridging in children with hypertrophic cardiomyopathy--a risk factor for sudden death. N Engl J Med. 1998; 339(17): 1201–1209.
- Channer KS, Bukis E, Hartnell G, et al. Myocardial bridging of the coronary arteries. Clin Radiol. 1989; 40(4): 355–359.
- Hansen BF. Myocardial covering on epicardial coronary arteries. Prevalence, localization and significance. Scand J Thorac Cardiovasc Surg. 1982; 16(2): 151–155.
- Debbarma J, Das P, Debbarma A. Myocardial bridging and sudden death: a care report. J Evolution Med Dental Scien. 2002; 4: 116–119.
- Alegria JR, Herrmann J, Holmes DR, et al. Myocardial bridging. Eur Heart J. 2005; 26(12): 1159–1168.
- Ishii T, Asuwa N, Masuda S, et al. The effects of a myocardial bridge on coronary atherosclerosis and ischaemia. J Pathol. 1998; 185(1): 4–9, doi: 10.1002/(SICI)1096-9896(199805)185:1<4::AID-PATH50>3.0.CO;2-3.
- Ishii T, Hosoda Y, Osaka T, et al. The significance of myocardial bridge upon atherosclerosis in the left anterior descending coronary artery. J Pathol. 1986; 148(4): 279–291.
- Chiu JJ, Wang DL, Chien S, et al. Effects of disturbed flow on endothelial cells. J Biomech Eng. 1998; 120(1): 2–8.
- Rosencrance G, Deer TR, Lee KC, et al. Coronary artery muscle bridging causing class III angina in a patient with no coronary atherosclerosis. W V Med J. 1995; 91(5): 196–197.
- Zheng Z, Xu G, Li W, et al. Effect of myocardial bridge on blood flow of coronary arter. J Shanghai Jiaotong University (Med Sci). 2006; 26: 166–168.
- Warboys CM, Amini N, de Luca A, et al. The role of blood flow in determining the sites of atherosclerotic plaques. F1000 Med Rep. 2011; 3: 5.
- Woo KV, Qu X, Babaev VR, et al. Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress-specific manner. J Clin Invest. 2011; 121(4): 1624–1635.
- Ravensbergen J, Ravensbergen JW, Krijger JK, et al. Localizing role of hemodynamics in atherosclerosis in several human vertebrobasilar junction geometries. Arterioscler Thromb Vasc Biol. 1998; 18(5): 708–716.
- Jenei C, Balogh E, Szabó GT, et al. Wall shear stress in the development of in-stent restenosis revisited. A critical review of clinical data on shear stress after intracoronary stent implantation. Cardiol J. 2016; 23(4): 365–373.
- Pan S. Molecular mechanisms responsible for the atheroprotective effects of laminar shear stress. Antioxid Redox Signal. 2009; 11(7): 1669–1682.
- Ding H, Shen L, Xu GL, et al. Heart pump system in heart-coronary artery-myocardial bridge circulation apparatus. J University of Shanghai for Science and Technology. 2003; 25: 201–204.
- Zhang H, Huang Y. Hydraulic transmission. Chinese Machine Press, Beijing. ; 1991.
- Ding H, Qiao A, Shen L, et al. Design of compliance chamber and after-load in apparatus for cultured endothelial cells subjected to stresses. Cell Biol Int. 2006; 30(5): 439–444.
- Noble J, Bourassa MG, Dyrda I, et al. Myocardial bridging and milking effect of the left anterior descending coronary artery: normal variant or obstruction? Am J Cardiol. 1976; 37(7): 993–999.
- Xu G, Qin K, Liu Z, et al. Calculation of the shear stress in the parallel-plate flow chamber under pulsatile flow condition. Chinese Quarterly Mech. 2000; 21: 45–51.
- Liu B, Liu Z. Fluid shear stress distribution of periodic oscillatory blood flow in rigid circular tube. Chinese Quarterly Mech. 2002; 23: 7–8.
- Jun Y, Tao G. The discussion of normal blood viscosity. Chin J Hemorheol. 1998; 8: 69.
- Zhang G, Ge J, Shen L, et al. Design and manufacture of medeling of fluid dynamics related to the myocardial bridging and mural coronary artery. J Biomed Eng. 2005; 22: 593–597.
- Xinghua G, Hua W, Keqiang W, et al. The effect of shear stress on endothelium membrane fluidity. Chin J Anat. 2000; 23: 352–354.
- Werner M, Bräunlich S, Ulrich M, et al. Drug-eluting stents for the treatment of vertebral artery origin stenosis. J Endovasc Ther. 2010; 17(2): 232–240.
- Haiqiang Q, Xingquan Z, Ping Z, et al. Preliminary study for association of blood pressure and heart rate on carotid hemodynamics. Chin J Stroke. 2012; 7: 461–465.
- Niu J, Dai X, Qiao A, et al. Hemodynamics analysis of vertebral artery ostium stenosis treated with stent implantation undergoing different protrusion distances. J Med Biomech. 2012; 27: 598–602.
- Gao J, Wang G, Xiao J. Numerical simulation of hemodynamics in suturing and sutureless anastomotic models. Chin J Biomed Engineering. 2012; 31: 866–874.
- Mintz GS. Clinical utility of intravascular imaging and physiology in coronary artery disease. J Am Coll Cardiol. 2014; 64(2): 207–222.
- Peng H, Yang D. [A boundary element analysis on hemodynamic characteristics at the bifurcation of abdominal arterial]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2012; 29(4): 697–700.
- Yang J, Liu J, Yu H, et al. Comparison of hemodynamics in iliac aortic with thrombosis and normal iliac aortic based on numerical simulation. BME Clin Med. 2012; 16: 1–6.
- Ling S-L, Zhang Y, Liao B, et al. The influence of low laminar shear stress on the expression of scavenger receptor B I in endothelial cells. Chin J Arterioscler. 2009; 17: 661–664.
- Stone PH, Coskun AU, Kinlay S, et al. Effect of endothelial shear stress on the progression of coronary artery disease, vascular remodeling, and in-stent restenosis in humans: in vivo 6-month follow-up study. Circulation. 2003; 108(4): 438–444.
- Pivkin IV, Richardson PD, Laidlaw DH, et al. Combined effects of pulsatile flow and dynamic curvature on wall shear stress in a coronary artery bifurcation model. J Biomech. 2005; 38(6): 1283–1290.
- Chaichana T, Sun Z, Jewkes J. Impact of plaques in the left coronary artery on wall shear stress and pressure gradient in coronary side branches. Com Methods in Biomech Biomed Engineer. 2013; 17: 108–118.
- Zhou Y, Ding H, Xu M, et al. Effect of oscillatory shear stress on endothelial cells in cell culture system. J Clin Rehab Tissue Eng Res. 2009; 13: 1669–1671.
- Liu Z, Li X. Principles and methods of blood dynamics. Shanghai, Fudan University Press. ; 1997.
