open access

Vol 23, No 4 (2016)
CLINICAL CARDIOLOGY Original articles
Published online: 2016-06-16
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Increased Rho kinase activity predicts worse cardiovascular outcome in ST-segment elevation myocardial infarction patients

Xiaohui Li, Xing Wu, Hongwei Li, Hui Chen, Yongliang Wang, Weiping Li, Xiaosong Ding, Xu Hong
DOI: 10.5603/CJ.a2016.0031
·
Pubmed: 27320957
·
Cardiol J 2016;23(4):456-464.

open access

Vol 23, No 4 (2016)
CLINICAL CARDIOLOGY Original articles
Published online: 2016-06-16

Abstract

Background: Few clinical studies have assessed Rho kinase (ROCK) in patients with dia­betes mellitus (DM) and ST-segment elevation myocardial infarction (STEMI). This study aimed to determine whether ROCK activity in circulating leukocytes is increased in STEMI patients with DM and whether ROCK activity predicts the onset of cardiovascular events.

Methods: Blood samples were collected from 60 STEMI patients, divided into non-diabetes mellitus (NDM) and DM groups. Main outcome measures were all-cause mortality, readmission for acute coronary syndrome (ACS), congestive heart failure (CHF), or stroke from pres­entation to approximately 5 years (mean: 41.3 ± 19.6 months; range: 3–60 months).

Results: Compared with the NDM group (n = 34), ROCK1 activity was greater in the DM group (n = 26) (33.14 ± 11.31 vs. 26.24 ± 11.06, p = 0.021), while ROCK2 activity was not different between the groups. There occurred 3 deaths, and 10 readmissions with ACS, 4 with CHF and 2 with stroke during the follow-up period. Patients with a high ROCK1 activity on admission had a 3-fold risk of cardiovascular events (RR 3.15, 95% CI 1.04–9.58) compared with those with low ROCK1 activity. Patients with history of stroke had almost a 4-fold risk of cardiovascular events (RR 3.74; 95% CI 1.02–13.80).

Conclusions: ROCK1 activity was increased in STEMI patients with DM, which suggests that ROCK1 activity may be a useful diagnostic and prognostic marker of cardiovascular events for these patients. ROCK1 activity might help identify a subset of STEMI patients at particularly high risk.

Abstract

Background: Few clinical studies have assessed Rho kinase (ROCK) in patients with dia­betes mellitus (DM) and ST-segment elevation myocardial infarction (STEMI). This study aimed to determine whether ROCK activity in circulating leukocytes is increased in STEMI patients with DM and whether ROCK activity predicts the onset of cardiovascular events.

Methods: Blood samples were collected from 60 STEMI patients, divided into non-diabetes mellitus (NDM) and DM groups. Main outcome measures were all-cause mortality, readmission for acute coronary syndrome (ACS), congestive heart failure (CHF), or stroke from pres­entation to approximately 5 years (mean: 41.3 ± 19.6 months; range: 3–60 months).

Results: Compared with the NDM group (n = 34), ROCK1 activity was greater in the DM group (n = 26) (33.14 ± 11.31 vs. 26.24 ± 11.06, p = 0.021), while ROCK2 activity was not different between the groups. There occurred 3 deaths, and 10 readmissions with ACS, 4 with CHF and 2 with stroke during the follow-up period. Patients with a high ROCK1 activity on admission had a 3-fold risk of cardiovascular events (RR 3.15, 95% CI 1.04–9.58) compared with those with low ROCK1 activity. Patients with history of stroke had almost a 4-fold risk of cardiovascular events (RR 3.74; 95% CI 1.02–13.80).

Conclusions: ROCK1 activity was increased in STEMI patients with DM, which suggests that ROCK1 activity may be a useful diagnostic and prognostic marker of cardiovascular events for these patients. ROCK1 activity might help identify a subset of STEMI patients at particularly high risk.

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Keywords

Rho kinase activity, diabetes mellitus, ST-segment elevation myocardial infarction, circulating leukocytes, insulin resistance

About this article
Title

Increased Rho kinase activity predicts worse cardiovascular outcome in ST-segment elevation myocardial infarction patients

Journal

Cardiology Journal

Issue

Vol 23, No 4 (2016)

Pages

456-464

Published online

2016-06-16

DOI

10.5603/CJ.a2016.0031

Pubmed

27320957

Bibliographic record

Cardiol J 2016;23(4):456-464.

Keywords

Rho kinase activity
diabetes mellitus
ST-segment elevation myocardial infarction
circulating leukocytes
insulin resistance

Authors

Xiaohui Li
Xing Wu
Hongwei Li
Hui Chen
Yongliang Wang
Weiping Li
Xiaosong Ding
Xu Hong

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