open access

Vol 23, No 4 (2016)
INTERVENTION/VALVULAR HEART DISEASE - Review articles
Published online: 2016-07-20
Get Citation

Wall shear stress in the development of in-stent restenosis revisited. A critical review of clinical data on shear stress after intracoronary stent implantation

Csaba Jenei, Emília Balogh, Gábor Tamás Szabó, Csaba András Dézsi, Zsolt Kőszegi
DOI: 10.5603/CJ.a2016.0047
·
Pubmed: 27439365
·
Cardiol J 2016;23(4):365-373.

open access

Vol 23, No 4 (2016)
INTERVENTION/VALVULAR HEART DISEASE - Review articles
Published online: 2016-07-20

Abstract

The average wall shear stress (WSS) is in 1 Pa range in coronary arteries, while the stretching effect of an implanted coronary stent can generate up to 3 × 105 times higher circumferential stress in the vessel wall. It is widely accepted that WSS plays a critical role in the development of restenosis after coronary stent implantation, but relevant clinical endpoint studies are lack­ing. Fluid dynamics modeling suggests an association between WSS and intimal hyperplasia, however, such an association is not established when the compensating healing process becomes an overshoot phenomenon. This review summarizes available clinical results and concepts of potential clinical importance.

Abstract

The average wall shear stress (WSS) is in 1 Pa range in coronary arteries, while the stretching effect of an implanted coronary stent can generate up to 3 × 105 times higher circumferential stress in the vessel wall. It is widely accepted that WSS plays a critical role in the development of restenosis after coronary stent implantation, but relevant clinical endpoint studies are lack­ing. Fluid dynamics modeling suggests an association between WSS and intimal hyperplasia, however, such an association is not established when the compensating healing process becomes an overshoot phenomenon. This review summarizes available clinical results and concepts of potential clinical importance.

Get Citation

Keywords

wall shear stress, percutaneous coronary intervention, stent implantation, in-stent restenosis

About this article
Title

Wall shear stress in the development of in-stent restenosis revisited. A critical review of clinical data on shear stress after intracoronary stent implantation

Journal

Cardiology Journal

Issue

Vol 23, No 4 (2016)

Pages

365-373

Published online

2016-07-20

DOI

10.5603/CJ.a2016.0047

Pubmed

27439365

Bibliographic record

Cardiol J 2016;23(4):365-373.

Keywords

wall shear stress
percutaneous coronary intervention
stent implantation
in-stent restenosis

Authors

Csaba Jenei
Emília Balogh
Gábor Tamás Szabó
Csaba András Dézsi
Zsolt Kőszegi

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