open access

Vol 23, No 3 (2016)
INTERVENTIONS Original articles
Published online: 2015-12-04
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The impact of admission red cell distribution width on long-term cardiovascular events after primary percutaneous intervention: A four-year prospective study

Turgay Isik, Mustafa Kurt, Ibrahim Halil Tanboga, Erkan Ayhan, Zeki Yuksel Gunaydin, Ahmet Kaya, Huseyin Uyarel
DOI: 10.5603/CJ.a2015.0080
·
Pubmed: 26711461
·
Cardiol J 2016;23(3):281-288.

open access

Vol 23, No 3 (2016)
INTERVENTIONS Original articles
Published online: 2015-12-04

Abstract

Background: Red cell distribution width (RDW) is an indicator of erythrocyte in different size, and its prognostic value has been demonstrated in numerous cardiac and non-cardiac diseases. The purpose of this study was to evaluate the predictive value of RDW on the long- -term cardiovascular events in patients undergoing primary percutaneous coronary intervention (PCI).

Methods: Ninety-six consecutive patients (mean age 60.6 ± 12.5 years, 77.1% male) with ST-segment elevation myocardial infarction (STEMI), who were treated with primary PCI, were analyzed prospectively. Baseline RDW and high sensitive C-reactive protein (hs-CRP) were measured. The patients were followed up for major adverse cardiac events (MACE) for up to 48 months after discharge.

Results: There were 30 patients with long-term MACE (Group 1) and 66 patients without long-term MACE (Group 2). Age, admission RDW, hs-CRP and creatine kinase-MB levels, heart rate after PCI, previously used angiotensin converting enzyme inhibitor, left anterior descending artery lesion, and electrocardiographic no-reflow were higher in Group 1. Admission hemoglobin levels were lower in Group 1. An RDW level ≥ 13.85% measured on admission had 80% sensitivity and 64% specificity in predicting long-term MACE on receiver-operating characteristic curve analysis. In multivariate analyses, only admission RDW (HR 5.26, < 95% CI 1.71–16.10; p = 0.004) was an independent predictor of long-term MACE.

Conclusions: A high baseline RDW value in patients with STEMI undergoing primary PCI is independently associated with increased risk for long term MACE.

Abstract

Background: Red cell distribution width (RDW) is an indicator of erythrocyte in different size, and its prognostic value has been demonstrated in numerous cardiac and non-cardiac diseases. The purpose of this study was to evaluate the predictive value of RDW on the long- -term cardiovascular events in patients undergoing primary percutaneous coronary intervention (PCI).

Methods: Ninety-six consecutive patients (mean age 60.6 ± 12.5 years, 77.1% male) with ST-segment elevation myocardial infarction (STEMI), who were treated with primary PCI, were analyzed prospectively. Baseline RDW and high sensitive C-reactive protein (hs-CRP) were measured. The patients were followed up for major adverse cardiac events (MACE) for up to 48 months after discharge.

Results: There were 30 patients with long-term MACE (Group 1) and 66 patients without long-term MACE (Group 2). Age, admission RDW, hs-CRP and creatine kinase-MB levels, heart rate after PCI, previously used angiotensin converting enzyme inhibitor, left anterior descending artery lesion, and electrocardiographic no-reflow were higher in Group 1. Admission hemoglobin levels were lower in Group 1. An RDW level ≥ 13.85% measured on admission had 80% sensitivity and 64% specificity in predicting long-term MACE on receiver-operating characteristic curve analysis. In multivariate analyses, only admission RDW (HR 5.26, < 95% CI 1.71–16.10; p = 0.004) was an independent predictor of long-term MACE.

Conclusions: A high baseline RDW value in patients with STEMI undergoing primary PCI is independently associated with increased risk for long term MACE.

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Keywords

red cell distribution width, ST-segment elevation myocardial infarction, long-term prognosis

About this article
Title

The impact of admission red cell distribution width on long-term cardiovascular events after primary percutaneous intervention: A four-year prospective study

Journal

Cardiology Journal

Issue

Vol 23, No 3 (2016)

Pages

281-288

Published online

2015-12-04

DOI

10.5603/CJ.a2015.0080

Pubmed

26711461

Bibliographic record

Cardiol J 2016;23(3):281-288.

Keywords

red cell distribution width
ST-segment elevation myocardial infarction
long-term prognosis

Authors

Turgay Isik
Mustafa Kurt
Ibrahim Halil Tanboga
Erkan Ayhan
Zeki Yuksel Gunaydin
Ahmet Kaya
Huseyin Uyarel

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