open access

Vol 23, No 1 (2016)
Original articles
Published online: 2015-09-23
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Neutrophil/lymphocyte ratio is associated with right ventricular dysfunction in patients with acute inferior ST-segment elevation myocardial infarction

Barıs Yaylak, Huseyin Ede, Erkan Baysal, Bernas Altıntas, Sukru Akyuz, Utkan Sevuk, Guney Erdoğan, Nuri Comert, Ender Ozgun Cakmak, Rojhat Altındag, Zulkuf Karahan, Onder Bilge, Kemal Cevik
DOI: 10.5603/CJ.a2015.0061
·
Pubmed: 26412608
·
Cardiol J 2016;23(1):100-106.

open access

Vol 23, No 1 (2016)
Original articles
Published online: 2015-09-23

Abstract

Background: Acute inferior ST-segment elevation myocardial infarction (STEMI) is associated with increased in-hospital morbidity and mortality particularly among patients with coexisting right ventricular (RV) involvement. High neutrophil to lymphocyte ratio (NLR) is an independent predictor of major adverse cardiac events and mortality in patients with myocardial infarction. This study evaluated the relationship between the NLR and RV dysfunction (RVD) in patients with inferior STEMI who underwent primary percutaneous coronary intervention (PCI).

Methods: A total of 213 subjects with inferior STEMI were divided into two groups according to the presence of RVD. The groups were compared according to NLR and receiver operating characteristic (ROC) analysis was performed to access the predictability of NLR on having RVD.

Results: The NLR was significantly higher in the group with RVD compared to that without RVD (p < 0.001). In ROC analysis, NLR > 3.5 predicted RVD with sensitivity of 83% and specificity of 55%. In a multivariate regression analysis, NLR remained an independent predictor of RVD (OR 1.55, 95% CI 1.285–1.750, p < 0.001).

Conclusions: NLR was an independent predictor of RVD in patients with inferior STEMI undergoing primary PCI.  

Abstract

Background: Acute inferior ST-segment elevation myocardial infarction (STEMI) is associated with increased in-hospital morbidity and mortality particularly among patients with coexisting right ventricular (RV) involvement. High neutrophil to lymphocyte ratio (NLR) is an independent predictor of major adverse cardiac events and mortality in patients with myocardial infarction. This study evaluated the relationship between the NLR and RV dysfunction (RVD) in patients with inferior STEMI who underwent primary percutaneous coronary intervention (PCI).

Methods: A total of 213 subjects with inferior STEMI were divided into two groups according to the presence of RVD. The groups were compared according to NLR and receiver operating characteristic (ROC) analysis was performed to access the predictability of NLR on having RVD.

Results: The NLR was significantly higher in the group with RVD compared to that without RVD (p < 0.001). In ROC analysis, NLR > 3.5 predicted RVD with sensitivity of 83% and specificity of 55%. In a multivariate regression analysis, NLR remained an independent predictor of RVD (OR 1.55, 95% CI 1.285–1.750, p < 0.001).

Conclusions: NLR was an independent predictor of RVD in patients with inferior STEMI undergoing primary PCI.  

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Keywords

neutrophil/lymphocyte ratio, inferior wall myocardial infarction, right ventricular dysfunction, primary percutaneous coronary intervention

About this article
Title

Neutrophil/lymphocyte ratio is associated with right ventricular dysfunction in patients with acute inferior ST-segment elevation myocardial infarction

Journal

Cardiology Journal

Issue

Vol 23, No 1 (2016)

Pages

100-106

Published online

2015-09-23

DOI

10.5603/CJ.a2015.0061

Pubmed

26412608

Bibliographic record

Cardiol J 2016;23(1):100-106.

Keywords

neutrophil/lymphocyte ratio
inferior wall myocardial infarction
right ventricular dysfunction
primary percutaneous coronary intervention

Authors

Barıs Yaylak
Huseyin Ede
Erkan Baysal
Bernas Altıntas
Sukru Akyuz
Utkan Sevuk
Guney Erdoğan
Nuri Comert
Ender Ozgun Cakmak
Rojhat Altındag
Zulkuf Karahan
Onder Bilge
Kemal Cevik

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