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Neutrophil/lymphocyte ratio is associated with right ventricular dysfunction in patients with acute inferior ST-segment elevation myocardial infarction
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Abstract
Background: Acute inferior ST-segment elevation myocardial infarction (STEMI) is associated with increased in-hospital morbidity and mortality particularly among patients with coexisting right ventricular (RV) involvement. High neutrophil to lymphocyte ratio (NLR) is an independent predictor of major adverse cardiac events and mortality in patients with myocardial infarction. This study evaluated the relationship between the NLR and RV dysfunction (RVD) in patients with inferior STEMI who underwent primary percutaneous coronary intervention (PCI).
Methods: A total of 213 subjects with inferior STEMI were divided into two groups according to the presence of RVD. The groups were compared according to NLR and receiver operating characteristic (ROC) analysis was performed to access the predictability of NLR on having RVD.
Results: The NLR was significantly higher in the group with RVD compared to that without RVD (p < 0.001). In ROC analysis, NLR > 3.5 predicted RVD with sensitivity of 83% and specificity of 55%. In a multivariate regression analysis, NLR remained an independent predictor of RVD (OR 1.55, 95% CI 1.285–1.750, p < 0.001).
Conclusions: NLR was an independent predictor of RVD in patients with inferior STEMI undergoing primary PCI.
Abstract
Background: Acute inferior ST-segment elevation myocardial infarction (STEMI) is associated with increased in-hospital morbidity and mortality particularly among patients with coexisting right ventricular (RV) involvement. High neutrophil to lymphocyte ratio (NLR) is an independent predictor of major adverse cardiac events and mortality in patients with myocardial infarction. This study evaluated the relationship between the NLR and RV dysfunction (RVD) in patients with inferior STEMI who underwent primary percutaneous coronary intervention (PCI).
Methods: A total of 213 subjects with inferior STEMI were divided into two groups according to the presence of RVD. The groups were compared according to NLR and receiver operating characteristic (ROC) analysis was performed to access the predictability of NLR on having RVD.
Results: The NLR was significantly higher in the group with RVD compared to that without RVD (p < 0.001). In ROC analysis, NLR > 3.5 predicted RVD with sensitivity of 83% and specificity of 55%. In a multivariate regression analysis, NLR remained an independent predictor of RVD (OR 1.55, 95% CI 1.285–1.750, p < 0.001).
Conclusions: NLR was an independent predictor of RVD in patients with inferior STEMI undergoing primary PCI.
Keywords
neutrophil/lymphocyte ratio, inferior wall myocardial infarction, right ventricular dysfunction, primary percutaneous coronary intervention
About this articleTitle
Neutrophil/lymphocyte ratio is associated with right ventricular dysfunction in patients with acute inferior ST-segment elevation myocardial infarction
Journal
Issue
Pages
100-106
Published online
2015-09-23
Page views
2337
Article views/downloads
1989
DOI
10.5603/CJ.a2015.0061
Pubmed
Bibliographic record
Cardiol J 2016;23(1):100-106.
Keywords
neutrophil/lymphocyte ratio
inferior wall myocardial infarction
right ventricular dysfunction
primary percutaneous coronary intervention
Authors
Barıs Yaylak
Huseyin Ede
Erkan Baysal
Bernas Altıntas
Sukru Akyuz
Utkan Sevuk
Guney Erdoğan
Nuri Comert
Ender Ozgun Cakmak
Rojhat Altındag
Zulkuf Karahan
Onder Bilge
Kemal Cevik
