open access

Vol 22, No 4 (2015)
Original articles
Published online: 2015-08-28
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White blood cell count to mean platelet volume ratio as a novel non-invasive marker predicting long-term outcomes in patients with non-ST elevation acute coronary syndrome

Mohammad Reza Dehghani, Yousef Rezaei, Leila Taghipour-Sani
DOI: 10.5603/CJ.a2015.0015
·
Pubmed: 25733319
·
Cardiol J 2015;22(4):437-445.

open access

Vol 22, No 4 (2015)
Original articles
Published online: 2015-08-28

Abstract

Background: Total white blood cell (WBC) count and mean platelet volume have previously been shown to predict outcomes in acute coronary syndrome (ACS) patients. In this prospective study, we sought to determine the prognostic value of baseline WBC count to mean platelet volume ratio (WMR) in patients with non-ST elevation acute coronary syndrome (NSTE-ACS).

Methods: A total of 490 patients with NSTE-ACS were prospectively enrolled. The relationship between baseline WMR and major adverse cardiovascular events (MACE) incidence was assessed during a mean follow-up of 330.8 ± 38 days.

Results: The patients’ mean age was 60.4 ± 12.9 year, 59% of them were male. The patients were categorized into two groups based on WMR values, high- and low-WMR groups (< 755 vs. ≥ 755). The incidence of MACE was significantly higher in high-WMR compared with that of low-WMR group (22.4% vs. 10.7%, p < 0.001). Total WBC counts (median 7.9 vs. 6.9 ×103/μL, p = 0.004), neutrophil count (median 4.6 vs. 4.2 ×103/μL, p = 0.021), and WMR (median 863.2 vs. 731.5, p = 0.001) were significantly higher in the MACE-positive than MACE-negative group. The high-WMR was found to be significantly associated with the MACE-free survival rate (p < 0.001). In an adjusted cox regression model, the elevated WMR was independently predicted the incidence of MACE (hazard ratio 2.419, 95% CI 1.515–3.862, p < 0.001).

Conclusions: The elevated baseline WMR independently predicted the MACE incidence in patients with NSTE-ACS during long-term follow-up.  

Abstract

Background: Total white blood cell (WBC) count and mean platelet volume have previously been shown to predict outcomes in acute coronary syndrome (ACS) patients. In this prospective study, we sought to determine the prognostic value of baseline WBC count to mean platelet volume ratio (WMR) in patients with non-ST elevation acute coronary syndrome (NSTE-ACS).

Methods: A total of 490 patients with NSTE-ACS were prospectively enrolled. The relationship between baseline WMR and major adverse cardiovascular events (MACE) incidence was assessed during a mean follow-up of 330.8 ± 38 days.

Results: The patients’ mean age was 60.4 ± 12.9 year, 59% of them were male. The patients were categorized into two groups based on WMR values, high- and low-WMR groups (< 755 vs. ≥ 755). The incidence of MACE was significantly higher in high-WMR compared with that of low-WMR group (22.4% vs. 10.7%, p < 0.001). Total WBC counts (median 7.9 vs. 6.9 ×103/μL, p = 0.004), neutrophil count (median 4.6 vs. 4.2 ×103/μL, p = 0.021), and WMR (median 863.2 vs. 731.5, p = 0.001) were significantly higher in the MACE-positive than MACE-negative group. The high-WMR was found to be significantly associated with the MACE-free survival rate (p < 0.001). In an adjusted cox regression model, the elevated WMR was independently predicted the incidence of MACE (hazard ratio 2.419, 95% CI 1.515–3.862, p < 0.001).

Conclusions: The elevated baseline WMR independently predicted the MACE incidence in patients with NSTE-ACS during long-term follow-up.  

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Keywords

white blood cell to mean platelet volume ratio, non-ST elevation acute coronary syndrome, major adverse cardiovascular events

About this article
Title

White blood cell count to mean platelet volume ratio as a novel non-invasive marker predicting long-term outcomes in patients with non-ST elevation acute coronary syndrome

Journal

Cardiology Journal

Issue

Vol 22, No 4 (2015)

Pages

437-445

Published online

2015-08-28

DOI

10.5603/CJ.a2015.0015

Pubmed

25733319

Bibliographic record

Cardiol J 2015;22(4):437-445.

Keywords

white blood cell to mean platelet volume ratio
non-ST elevation acute coronary syndrome
major adverse cardiovascular events

Authors

Mohammad Reza Dehghani
Yousef Rezaei
Leila Taghipour-Sani

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