open access

Vol 21, No 5 (2014)
Original articles
Published online: 2014-10-29
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Influence of cardiac resynchronization therapy on oxidative stress markers in patients with chronic heart failure

Wojciech Krupa, Małgorzata Rozwodowska, Sławomir Sielski, Ewa Czarnecka-Żaba, Tomasz Fabiszak, Gerard Drewa, Michał Kasprzak, Jacek Kubica
DOI: 10.5603/CJ.a2014.0051
·
Cardiol J 2014;21(5):576-582.

open access

Vol 21, No 5 (2014)
Original articles
Published online: 2014-10-29

Abstract

Background: The aim of the study was to assess changes of substances of oxidative stress in patients treated with cardiac resynchronization therapy (CRT).

Methods: The study comprised 51 patients with median age of 66 years. The presence, severity, and changes of oxidative stress during CRT were assessed and expressed as malondialdehyde (MDA) concentration in plasma or in red blood cells. Antioxidant activity was assessed by the activity of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) in red blood cells. The concentration and activities were analyzed directly prior to implantation, 2–5 days after the procedure and after 6 months. Follow-up (6 months) included clinical, echocardiographic and implanted device assessments.

Results: During the follow-up, 14% patients died. The median percentage of biventricular pacing was 99.29%. After 6 months 88% of patients improved NYHA, 12% remained as non-responders. Left ventricular ejection fraction increased from median 21.5% to 29% (p < 0.05). Left ventricular end-diastolic diameter decreased significantly from a median of 69.5 mm to 63 mm (p < 0.05). After a 6-month study, MDA plasma concentration and the activity levels of each antioxidant enzymes (CAT, SOD, GPx) showed a statistically significant reduction (p < 0.05). Changes concerning MDA concentrations in red blood cells remained statistically insignificant.

Conclusions: Resynchronization effect oxidative stress by reducing plasma concentration of MDA, CAT, SOD and GPX.

Abstract

Background: The aim of the study was to assess changes of substances of oxidative stress in patients treated with cardiac resynchronization therapy (CRT).

Methods: The study comprised 51 patients with median age of 66 years. The presence, severity, and changes of oxidative stress during CRT were assessed and expressed as malondialdehyde (MDA) concentration in plasma or in red blood cells. Antioxidant activity was assessed by the activity of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) in red blood cells. The concentration and activities were analyzed directly prior to implantation, 2–5 days after the procedure and after 6 months. Follow-up (6 months) included clinical, echocardiographic and implanted device assessments.

Results: During the follow-up, 14% patients died. The median percentage of biventricular pacing was 99.29%. After 6 months 88% of patients improved NYHA, 12% remained as non-responders. Left ventricular ejection fraction increased from median 21.5% to 29% (p < 0.05). Left ventricular end-diastolic diameter decreased significantly from a median of 69.5 mm to 63 mm (p < 0.05). After a 6-month study, MDA plasma concentration and the activity levels of each antioxidant enzymes (CAT, SOD, GPx) showed a statistically significant reduction (p < 0.05). Changes concerning MDA concentrations in red blood cells remained statistically insignificant.

Conclusions: Resynchronization effect oxidative stress by reducing plasma concentration of MDA, CAT, SOD and GPX.

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Keywords

heart failure, cardiac resynchronization, oxidative stress

About this article
Title

Influence of cardiac resynchronization therapy on oxidative stress markers in patients with chronic heart failure

Journal

Cardiology Journal

Issue

Vol 21, No 5 (2014)

Pages

576-582

Published online

2014-10-29

DOI

10.5603/CJ.a2014.0051

Bibliographic record

Cardiol J 2014;21(5):576-582.

Keywords

heart failure
cardiac resynchronization
oxidative stress

Authors

Wojciech Krupa
Małgorzata Rozwodowska
Sławomir Sielski
Ewa Czarnecka-Żaba
Tomasz Fabiszak
Gerard Drewa
Michał Kasprzak
Jacek Kubica

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