open access

Vol 21, No 5 (2014)
Original articles
Published online: 2014-10-29
Submitted: 2013-10-27
Accepted: 2013-11-26
Get Citation

Effect of oral vitamin C on atrial fibrillation development after isolated coronary artery bypass grafting surgery: A prospective randomized clinical trial

Mohammad Reza Dehghani, Nader Majidi, Alireza Rahmani, Behnam Asgari, Yousef Rezaei
DOI: 10.5603/CJ.a2013.0154
·
Cardiol J 2014;21(5):492-499.

open access

Vol 21, No 5 (2014)
Original articles
Published online: 2014-10-29
Submitted: 2013-10-27
Accepted: 2013-11-26

Abstract

Background: Some evidences have shown the role of antioxidant vitamins in preventing atrial fibrillation (AF) after coronary artery bypass grafting (CABG) surgery. We sought to determine the effect of oral vitamin C on the incidence of postoperative AF in patients undergoing elective isolated on-pump CABG surgery.

Methods: One-hundred patients who underwent isolated CABG surgery were prospectively assigned into two groups: Group 1 — 50 patients received 2 g of oral vitamin C before and 500 mg twice daily lasting for 5 days after surgery; Group 2 — 50 patients as the control group did not receive any. All patients were continuously monitored after surgery in the intensive careunit (ICU), and then Holter monitoring was implemented for 72 h.

Results: The mean of patients’ age was 61.31 ± 6.42 years. Postoperative AF occurred in 16 and 4 patients in control and treatment groups, respectively (32% vs. 8%, p = 0.003). The ICU stay was 1.79 ± 0.313 and 2.10 ± 0.61 days for vitamin C and control groups, respectively (p = 0.002). The hospital stay was significantly lower in vitamin C group compared with that of the control group (5.32 ± 0.59 vs. 5.74 ± 1.30 days, respectively, p = 0.041). Baseline erythrocyte sedimentation rate (OR 1.030, 95% CI 1.003–1.058, p = 0.030) and taking vitamin C (OR 8.068, 95% CI 1.783–36.517, p = 0.007) were the independent predictors of postoperative AF.

Conclusions: Oral vitamin C can be safely used to decrease the incidence of postoperative AF in patients undergoing elective isolated on-pump CABG surgery.

Abstract

Background: Some evidences have shown the role of antioxidant vitamins in preventing atrial fibrillation (AF) after coronary artery bypass grafting (CABG) surgery. We sought to determine the effect of oral vitamin C on the incidence of postoperative AF in patients undergoing elective isolated on-pump CABG surgery.

Methods: One-hundred patients who underwent isolated CABG surgery were prospectively assigned into two groups: Group 1 — 50 patients received 2 g of oral vitamin C before and 500 mg twice daily lasting for 5 days after surgery; Group 2 — 50 patients as the control group did not receive any. All patients were continuously monitored after surgery in the intensive careunit (ICU), and then Holter monitoring was implemented for 72 h.

Results: The mean of patients’ age was 61.31 ± 6.42 years. Postoperative AF occurred in 16 and 4 patients in control and treatment groups, respectively (32% vs. 8%, p = 0.003). The ICU stay was 1.79 ± 0.313 and 2.10 ± 0.61 days for vitamin C and control groups, respectively (p = 0.002). The hospital stay was significantly lower in vitamin C group compared with that of the control group (5.32 ± 0.59 vs. 5.74 ± 1.30 days, respectively, p = 0.041). Baseline erythrocyte sedimentation rate (OR 1.030, 95% CI 1.003–1.058, p = 0.030) and taking vitamin C (OR 8.068, 95% CI 1.783–36.517, p = 0.007) were the independent predictors of postoperative AF.

Conclusions: Oral vitamin C can be safely used to decrease the incidence of postoperative AF in patients undergoing elective isolated on-pump CABG surgery.

Get Citation

Keywords

atrial fibrillation, coronary artery bypass grafting, ascorbic acid, vitamin C

About this article
Title

Effect of oral vitamin C on atrial fibrillation development after isolated coronary artery bypass grafting surgery: A prospective randomized clinical trial

Journal

Cardiology Journal

Issue

Vol 21, No 5 (2014)

Pages

492-499

Published online

2014-10-29

DOI

10.5603/CJ.a2013.0154

Bibliographic record

Cardiol J 2014;21(5):492-499.

Keywords

atrial fibrillation
coronary artery bypass grafting
ascorbic acid
vitamin C

Authors

Mohammad Reza Dehghani
Nader Majidi
Alireza Rahmani
Behnam Asgari
Yousef Rezaei

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: viamedica@viamedica.pl