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open access

Vol 20, No 5 (2013)
Review Article
Submitted: 2013-10-03
Accepted: 2013-10-03
Published online: 2013-09-30
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Baroreceptor sensitivity and diabetes mellitus

Olumide Olatubosun Rowaiye, Ewa Anita Jankowska, Beata Ponikowska
DOI: 10.5603/CJ.2013.0130
·
Cardiol J 2013;20(5):453-463.

open access

Vol 20, No 5 (2013)
Review articles
Submitted: 2013-10-03
Accepted: 2013-10-03
Published online: 2013-09-30

Abstract

Diabetes mellitus (DM) is a disease of increasing incidence and prevalence. Arterial baroreceptors are stretch-sensitive receptors, which in a reflex manner are involved in the homeostatic control of arterial blood pressure. Diabetic subjects have depressed baroreflex sensitivity (BRS), although the exact pathomechanisms are unclear. In this review, we discuss the features, clinicaland prognostic implications of reduced BRS for diabetic patients and the potential involvement of cardiovascular autonomic neuropathy and atherosclerosis. Finally, we demonstrate evidence on interventions (e.g. pioglitazone, alpha-lipoic acid, leptin, fluvastatin, physicaltraining etc.) which could improve BRS and ameliorate cardiovascular autonomic dysfunction in diabetic patients.

Abstract

Diabetes mellitus (DM) is a disease of increasing incidence and prevalence. Arterial baroreceptors are stretch-sensitive receptors, which in a reflex manner are involved in the homeostatic control of arterial blood pressure. Diabetic subjects have depressed baroreflex sensitivity (BRS), although the exact pathomechanisms are unclear. In this review, we discuss the features, clinicaland prognostic implications of reduced BRS for diabetic patients and the potential involvement of cardiovascular autonomic neuropathy and atherosclerosis. Finally, we demonstrate evidence on interventions (e.g. pioglitazone, alpha-lipoic acid, leptin, fluvastatin, physicaltraining etc.) which could improve BRS and ameliorate cardiovascular autonomic dysfunction in diabetic patients.

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Keywords

arterial baroreceptors, autonomic dysfunction, baroreflex sensitivity, cardiovascular autonomic neuropathy, diabetes mellitus

About this article
Title

Baroreceptor sensitivity and diabetes mellitus

Journal

Cardiology Journal

Issue

Vol 20, No 5 (2013)

Article type

Review Article

Pages

453-463

Published online

2013-09-30

Page views

3746

Article views/downloads

4281

DOI

10.5603/CJ.2013.0130

Bibliographic record

Cardiol J 2013;20(5):453-463.

Keywords

arterial baroreceptors
autonomic dysfunction
baroreflex sensitivity
cardiovascular autonomic neuropathy
diabetes mellitus

Authors

Olumide Olatubosun Rowaiye
Ewa Anita Jankowska
Beata Ponikowska

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