Vol 20, No 4 (2013)
Original articles
Published online: 2013-07-26
Oral health status and the occurrence and clinical course of myocardial infarction in hospital phase: A case-control study
DOI: 10.5603/CJ.2013.0095
Cardiol J 2013;20(4):370-377.
Abstract
Background: Periodontitis may contribute to destabilization of atherosclerotic plaque leading
to acute coronary syndrome and myocardial infarction (MI). The aim of the paper was to evaluate
the state of the oral cavity and test the association between chosen parameters of acute,
hospital phase MI in patients aged 60 and younger.
Methods: We examined patients with acute MI, age 60. Control group consisted of matched
group of patients with stable angina. Patients enrolled in the study underwent dental, cardiovascular
and biochemical examination. Left ventricular ejection fraction (LVEF) was measured
during echocardiographic examination, intima-media thickness (IMT) was assessed by
ultrasonographic examination at the same time.
Results: The case group included 112 hospital patients with acute MI. Patients with acute
MI were characterized by higher level of cardiovascular disease risk factors and poor oral health
status in comparison to the control group. There was higher prevalence of edentulousness
(p = 0.0039) and advanced periodontal disease (APD) (p < 0.0001) in the case group than in the
control group. Patients with edentulousness and APD were characterized by the highest levels of
fi brinogen, interleukine-6, tumor necrosis factor-a, increased IMT and numerous atherosclerotic
plaques. Logistic regression analysis revealed association between biomarkers of myocardial
injury, LVEF and chosen periodontal parameter (API, CAL, PDI, BI) and edentulousness.
Conclusions: Poor oral health status, especially periodontal disease may infl uence on the
occurrence and clinical course of MI.
to acute coronary syndrome and myocardial infarction (MI). The aim of the paper was to evaluate
the state of the oral cavity and test the association between chosen parameters of acute,
hospital phase MI in patients aged 60 and younger.
Methods: We examined patients with acute MI, age 60. Control group consisted of matched
group of patients with stable angina. Patients enrolled in the study underwent dental, cardiovascular
and biochemical examination. Left ventricular ejection fraction (LVEF) was measured
during echocardiographic examination, intima-media thickness (IMT) was assessed by
ultrasonographic examination at the same time.
Results: The case group included 112 hospital patients with acute MI. Patients with acute
MI were characterized by higher level of cardiovascular disease risk factors and poor oral health
status in comparison to the control group. There was higher prevalence of edentulousness
(p = 0.0039) and advanced periodontal disease (APD) (p < 0.0001) in the case group than in the
control group. Patients with edentulousness and APD were characterized by the highest levels of
fi brinogen, interleukine-6, tumor necrosis factor-a, increased IMT and numerous atherosclerotic
plaques. Logistic regression analysis revealed association between biomarkers of myocardial
injury, LVEF and chosen periodontal parameter (API, CAL, PDI, BI) and edentulousness.
Conclusions: Poor oral health status, especially periodontal disease may infl uence on the
occurrence and clinical course of MI.
Keywords: periodontal diseaseatherosclerosismyocardial infarction
