open access

Vol 21, No 3 (2014)
Original articles
Published online: 2014-06-09
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The relationship between glycemic control and BNP levels in diabetic patients

Kursat Dal, Naim Ata, Bunyamin Yavuz, Omer Sen, Onur Sinan Deveci, Zekeriya Aksoz, Aslihan Mete Yildirim, Bulent Uygungelen, Kadir Okhan Akin, Esin Beyan, Derun Taner Ertugrul
DOI: 10.5603/CJ.a2013.0109
·
Cardiol J 2014;21(3):252-256.

open access

Vol 21, No 3 (2014)
Original articles
Published online: 2014-06-09

Abstract

Background: Glycemic control affects cardiovascular risk factors positively. The purpose of this study was to assess B-type natriuretic peptide (BNP) levels in patients with poorly controlled diabetes before and after glycemic regulation was achieved.

Methods: The study was performed in a prospective design. The study population consisted of 79 consecutive diabetic patients with poor glycemic control. All subjects underwent transthoracic echocardiography. Levels of fasting plasma glucose, glycosylated hemoglobin (HbA1c), lipid parameters, and BNP were measured before the onset of the treatment and after glycemic regulation was achieved.

Results: A significant decrease in BNP (95.0 [4.0–1807] ng/L vs. 52.0 [2.1–987.0] ng/L, p < 0.001) levels were observed, after improving glycemic control. The decrease in BNP levels was positively correlated with the decrease in HbA1c (r = 0.345, p = 0.003) and fasting plasma glucose (r = 0.366, p = 0.002). There was no correlation between the decrease in BNP levels and lipid parameters (p = NS).

Conclusions: We conclude that poor glycemic control may cause high levels of BNP which maylead to overdiagnosis of congestive heart failure. We suggest that HbA1c and fasting plasma glucose should be checked in patients with high levels of BNP.

Abstract

Background: Glycemic control affects cardiovascular risk factors positively. The purpose of this study was to assess B-type natriuretic peptide (BNP) levels in patients with poorly controlled diabetes before and after glycemic regulation was achieved.

Methods: The study was performed in a prospective design. The study population consisted of 79 consecutive diabetic patients with poor glycemic control. All subjects underwent transthoracic echocardiography. Levels of fasting plasma glucose, glycosylated hemoglobin (HbA1c), lipid parameters, and BNP were measured before the onset of the treatment and after glycemic regulation was achieved.

Results: A significant decrease in BNP (95.0 [4.0–1807] ng/L vs. 52.0 [2.1–987.0] ng/L, p < 0.001) levels were observed, after improving glycemic control. The decrease in BNP levels was positively correlated with the decrease in HbA1c (r = 0.345, p = 0.003) and fasting plasma glucose (r = 0.366, p = 0.002). There was no correlation between the decrease in BNP levels and lipid parameters (p = NS).

Conclusions: We conclude that poor glycemic control may cause high levels of BNP which maylead to overdiagnosis of congestive heart failure. We suggest that HbA1c and fasting plasma glucose should be checked in patients with high levels of BNP.

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Keywords

glycemic control, diabetes, BNP, echocardiography, heart failure

About this article
Title

The relationship between glycemic control and BNP levels in diabetic patients

Journal

Cardiology Journal

Issue

Vol 21, No 3 (2014)

Pages

252-256

Published online

2014-06-09

DOI

10.5603/CJ.a2013.0109

Bibliographic record

Cardiol J 2014;21(3):252-256.

Keywords

glycemic control
diabetes
BNP
echocardiography
heart failure

Authors

Kursat Dal
Naim Ata
Bunyamin Yavuz
Omer Sen
Onur Sinan Deveci
Zekeriya Aksoz
Aslihan Mete Yildirim
Bulent Uygungelen
Kadir Okhan Akin
Esin Beyan
Derun Taner Ertugrul

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