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Is metabolic syndrome related with coronary artery disease severity and complexity: An observational study about IDF and AHA/NHLBI metabolic syndrome definitions
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Abstract
Background: The aim of the present study was to assess the relation between metabolic syndrome (MS) and coronary artery disease (CAD) complexity, assessed by Syntax score (SS), and severity in non-diabetic patients with stable CAD who underwent coronary angiography, and to evaluate whether the MS defined by different definitions, including International Diabetes Federation (IDF) and American Heart Association/National Heart Lung Blood Institute (AHA/NHLBI) guidelines, similarly correlated with SS.
Methods: The present study is cross sectional and observational with prospective inclusion of 248 consecutive patients (157 male) who underwent coronary angiography due to stable CAD.
Results: The prevalence of MS was 54.4% according to IDF definition and 50.4% according to AHA/NHLBI definition. MS score according to IDF definitions (r = 0.446, p < 0.001), MS score according to AHA/NHLBI definitions (r = 0.341, p < 0.001) were moderately correlated with SS. In Fisher r to z transformation test the correlations of the presence of MS according to IDF and AHA/NHLBI definitions with SS were not statistically significant (p = 0.168, z = –1.38). The systolic blood pressure (p < 0.001, B = 0.354, 95% CI = –0.308 to 0.228), diastolic blood pressure (p = 0.006, B = –0.194, 95% CI = –0.333 to –0.056), age (p = 0.014, B = 0.147, 95% CI = 0.029 to 0.264), left ventricular ejection fraction (p = 0.031, B = –0.150, 95% CI= –0.286 to –0.014), waist/hip circumference (p < 0.001, B = 45.713, 95% CI = 23.235 to 68.1919) and log10 high density lipoprotein (p < 0.001, B = –22.209, 95% CI = –33.298 to–11.119) were the independent predictors of SS in linear regression analysis.
Conclusions: MS is associated with the presence and complexity of CAD. Besides the presence of discrepancy in the limits of waist circumference, both IDF and AHA/NHLBI criteria were similarly correlated with CAD complexity.
Abstract
Background: The aim of the present study was to assess the relation between metabolic syndrome (MS) and coronary artery disease (CAD) complexity, assessed by Syntax score (SS), and severity in non-diabetic patients with stable CAD who underwent coronary angiography, and to evaluate whether the MS defined by different definitions, including International Diabetes Federation (IDF) and American Heart Association/National Heart Lung Blood Institute (AHA/NHLBI) guidelines, similarly correlated with SS.
Methods: The present study is cross sectional and observational with prospective inclusion of 248 consecutive patients (157 male) who underwent coronary angiography due to stable CAD.
Results: The prevalence of MS was 54.4% according to IDF definition and 50.4% according to AHA/NHLBI definition. MS score according to IDF definitions (r = 0.446, p < 0.001), MS score according to AHA/NHLBI definitions (r = 0.341, p < 0.001) were moderately correlated with SS. In Fisher r to z transformation test the correlations of the presence of MS according to IDF and AHA/NHLBI definitions with SS were not statistically significant (p = 0.168, z = –1.38). The systolic blood pressure (p < 0.001, B = 0.354, 95% CI = –0.308 to 0.228), diastolic blood pressure (p = 0.006, B = –0.194, 95% CI = –0.333 to –0.056), age (p = 0.014, B = 0.147, 95% CI = 0.029 to 0.264), left ventricular ejection fraction (p = 0.031, B = –0.150, 95% CI= –0.286 to –0.014), waist/hip circumference (p < 0.001, B = 45.713, 95% CI = 23.235 to 68.1919) and log10 high density lipoprotein (p < 0.001, B = –22.209, 95% CI = –33.298 to–11.119) were the independent predictors of SS in linear regression analysis.
Conclusions: MS is associated with the presence and complexity of CAD. Besides the presence of discrepancy in the limits of waist circumference, both IDF and AHA/NHLBI criteria were similarly correlated with CAD complexity.
Keywords
metabolic syndrome, Syntax score, coronary, cardiovascular, IDF, AHA/NHLBI
About this articleTitle
Is metabolic syndrome related with coronary artery disease severity and complexity: An observational study about IDF and AHA/NHLBI metabolic syndrome definitions
Journal
Issue
Pages
245-251
Published online
2014-06-09
Page views
2342
Article views/downloads
1722
DOI
10.5603/CJ.a2013.0126
Bibliographic record
Cardiol J 2014;21(3):245-251.
Keywords
metabolic syndrome
Syntax score
coronary
cardiovascular
IDF
AHA/NHLBI
Authors
Ahmet Çağrı Aykan
İlker Gül
Ezgi Kalaycıoğlu
Tayyar Gökdeniz
Engin Hatem
Ümit Menteşe
Banu Şahin Yıldız
Mustafa Yıldız
