open access

Vol 21, No 2 (2014)
Original articles
Published online: 2014-04-15
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A prospective study about impact of renal dysfunction and morbidity and mortality on cardiovascular events after ischemic stroke

Meta Penko, Tanja Hojs Fabjan, Sebastjan Bevc, Vojko Kanič, Radovan Hojs
DOI: 10.5603/CJ.a2013.0083
·
Cardiol J 2014;21(2):163-169.

open access

Vol 21, No 2 (2014)
Original articles
Published online: 2014-04-15

Abstract

Background: The aim of our prospective study was to define the impact of renal dysfunction on future cardiovascular events and total mortality in 390 patients suffering from ischemic stroke.

Methods: A quantitative measurement of neurologic deficit according to National Institutes of Health Stroke Scale (NIHSS) score was performed. Blood parameters were measured. Diabetes, hypertension and smoking habits were defined. Estimated glomerular filtration rate was calculated.

Results: 153 (39.2%) patients had renal dysfunction. In the follow-up period in 36 (9.2%) patients acute coronary syndrome, in 102 (26.2%) recurrent ischemic stroke and in 44 (11.3%) peripheral arterial disease were documented. 191 (49%) patient died, 118 (30.3%) of whom died of cardiovascular events. Patients who died were older, had higher prevalence of renal dysfunction and NIHSS score. The Kaplan-Meier survival analysis showed that total mortality (p < 0.003) and cardiovascular mortality (p < 0.01) were higher in patients with renal dysfunction. According to Cox’s regression analysis, renal dysfunction was the predictor of cardiovascular events, cardiovascular and total mortality.

Conclusions: Patients with ischemic stroke and renal dysfunction are at higher risk for long term cardiovascular and total mortality. The patients with ischemic stroke and renal dysfunction are also at higher risk of new cardiovascular morbidity. Renal dysfunction should be added to the other known prognostic factors in patients with ischemic stroke. Our results also emphasize the importance of identification and management of renal dysfunction in stroke patients.

 

Abstract

Background: The aim of our prospective study was to define the impact of renal dysfunction on future cardiovascular events and total mortality in 390 patients suffering from ischemic stroke.

Methods: A quantitative measurement of neurologic deficit according to National Institutes of Health Stroke Scale (NIHSS) score was performed. Blood parameters were measured. Diabetes, hypertension and smoking habits were defined. Estimated glomerular filtration rate was calculated.

Results: 153 (39.2%) patients had renal dysfunction. In the follow-up period in 36 (9.2%) patients acute coronary syndrome, in 102 (26.2%) recurrent ischemic stroke and in 44 (11.3%) peripheral arterial disease were documented. 191 (49%) patient died, 118 (30.3%) of whom died of cardiovascular events. Patients who died were older, had higher prevalence of renal dysfunction and NIHSS score. The Kaplan-Meier survival analysis showed that total mortality (p < 0.003) and cardiovascular mortality (p < 0.01) were higher in patients with renal dysfunction. According to Cox’s regression analysis, renal dysfunction was the predictor of cardiovascular events, cardiovascular and total mortality.

Conclusions: Patients with ischemic stroke and renal dysfunction are at higher risk for long term cardiovascular and total mortality. The patients with ischemic stroke and renal dysfunction are also at higher risk of new cardiovascular morbidity. Renal dysfunction should be added to the other known prognostic factors in patients with ischemic stroke. Our results also emphasize the importance of identification and management of renal dysfunction in stroke patients.

 

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Keywords

renal dysfunction, ischemic stroke, coronary heart disease, cardiovascular events, mortality

About this article
Title

A prospective study about impact of renal dysfunction and morbidity and mortality on cardiovascular events after ischemic stroke

Journal

Cardiology Journal

Issue

Vol 21, No 2 (2014)

Pages

163-169

Published online

2014-04-15

DOI

10.5603/CJ.a2013.0083

Bibliographic record

Cardiol J 2014;21(2):163-169.

Keywords

renal dysfunction
ischemic stroke
coronary heart disease
cardiovascular events
mortality

Authors

Meta Penko
Tanja Hojs Fabjan
Sebastjan Bevc
Vojko Kanič
Radovan Hojs

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