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Association of interleukin-4 gene polymorphisms with ischemic heart failure
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Abstract
Background: As of the potential immunomodulatory effects of interleukin-4 (IL-4) and its importance in inhibiting the production of proinflammatory cytokines by monocytes and activated T cells, the IL-4 gene polymorphisms were investigated in a group of patients with chronic heart failure due to ischemic heart disease.
Methods: Forty three patients with ischemic heart failure (IHF) were enrolled in this study and compared with 139 healthy individuals. The allele and genotype frequency of 3 single nucleotide polymorphisms within the IL-4 gene were determined.
Results: The frequency of the IL-4 –590/T allele in the patient group was significantly higher than in the control group (p < 0.0001). The most frequent genotypes in patients with IHF were IL-4 (–590) CC (p < 0.0001), IL-4 (–33) CC (p = 0.021), and IL-4 (–33) TT (p < 0.0001). The frequency of the following genotypes was significantly lower in patients compared to controls: IL-4 (–1098) TG (p = 0.035), IL-4 (–590) TC (p < 0.0001), and IL-4 (–33) TC (p < 0.0001). The most frequent IL-4 haplotypes in the patient group, which were significantly higher than in the control group, were TCC (p < 0.0001), TCT (p = 0.0242), and GCT (p = 0.0108) haplotypes. In contrast, the frequencies of the following haplotypes in the patient group were significantly lower than in the controls: GCC (p = 0.032), TTT (p = 0.0268), and TTC (p = 0.0399).
Conclusions: Certain alleles, genotypes, and haplotypes in IL-4 gene were over represented inpatients with IHF, which may, in turn, predispose individuals to this disease.
Abstract
Background: As of the potential immunomodulatory effects of interleukin-4 (IL-4) and its importance in inhibiting the production of proinflammatory cytokines by monocytes and activated T cells, the IL-4 gene polymorphisms were investigated in a group of patients with chronic heart failure due to ischemic heart disease.
Methods: Forty three patients with ischemic heart failure (IHF) were enrolled in this study and compared with 139 healthy individuals. The allele and genotype frequency of 3 single nucleotide polymorphisms within the IL-4 gene were determined.
Results: The frequency of the IL-4 –590/T allele in the patient group was significantly higher than in the control group (p < 0.0001). The most frequent genotypes in patients with IHF were IL-4 (–590) CC (p < 0.0001), IL-4 (–33) CC (p = 0.021), and IL-4 (–33) TT (p < 0.0001). The frequency of the following genotypes was significantly lower in patients compared to controls: IL-4 (–1098) TG (p = 0.035), IL-4 (–590) TC (p < 0.0001), and IL-4 (–33) TC (p < 0.0001). The most frequent IL-4 haplotypes in the patient group, which were significantly higher than in the control group, were TCC (p < 0.0001), TCT (p = 0.0242), and GCT (p = 0.0108) haplotypes. In contrast, the frequencies of the following haplotypes in the patient group were significantly lower than in the controls: GCC (p = 0.032), TTT (p = 0.0268), and TTC (p = 0.0399).
Conclusions: Certain alleles, genotypes, and haplotypes in IL-4 gene were over represented inpatients with IHF, which may, in turn, predispose individuals to this disease.
Keywords
heart failure, gene polymorphisms, interleukin-4
About this articleTitle
Association of interleukin-4 gene polymorphisms with ischemic heart failure
Journal
Issue
Pages
24-28
Published online
2014-02-13
Page views
2373
Article views/downloads
1980
DOI
10.5603/CJ.a2013.0049
Bibliographic record
Cardiol J 2014;21(1):24-28.
Keywords
heart failure
gene polymorphisms
interleukin-4
Authors
Mohammad Jafar Mahmoudi
Mona Hedayat
Mohammad Taghvaei
Ebrahim Nematipour
Elham Farhadi
Nilufar Esfahanian
Maryam Sadr
Maryam Mahmoudi
Keramat Nourijelyani
Ali Akbar Amirzargar
Nima Rezaei
