open access

Vol 19, No 5 (2012)
Original articles
Published online: 2012-10-06
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Lack of significant association between Helicobacter pylori infection and homocysteine levels in patients with cardiac syndrome X

Yousef Rasmi, Kamal Mehraban, Masoud Sadreddini, Javad Zeynalzadeh, Maryam Majidinia, MirHossein Seyyed-Mohammadzad, Homayoon Babazadeh
DOI: 10.5603/CJ.2012.0086
·
Cardiol J 2012;19(5):466-469.

open access

Vol 19, No 5 (2012)
Original articles
Published online: 2012-10-06

Abstract


Background: Helicobacter pylori (H.pylori) has been implicated in the pathogenesis of several diseases such as cardiac syndrome X (CSX), which includes chest pain, positive exercise stress test and normal angiography. Also, elevation of homocysteine (Hcy) level is associated with CSX, as it can severely disturb vascular endothelial function. We aimed to elucidate whether the infection of H.pylori affect the level of Hcy in CSX.
Methods: Eighty-eight patients with CSX (32 men, 56 women; mean age: 53.8 ± 11.9) and 97 healthy controls (36 men, 61 women; mean age: 45.7 ± 7.3) were enrolled. Plasma samples were tested for the presence of IgG antibody to H.pylori using enzyme linked immunosorbent assay method. Hcy levels were measured enzymatically.
Results: Plasma Hcy concentration in CSX patients is higher than control group (13.1 ± 2.6 vs. 11.8 ± 2.5 mmol/L; p = 0.002). There was no significant difference between Hcy in H.pylori+ and H.pylori individuals in CSX group (13.1 ± 2.7 vs. 12.2 ± 0.6 mmol/L; p = 0.554) and between two groups in controls, respectively (12.1 ± 2.2 vs. 11.4 ± 2.9 mmol/L; p = 0.148).
Conclusions: Although there is Hcy level increase in H.pylori+ CSX patients and controls comparing to H.pylori subjects, but other factors may affect on Hcy level, too. (Cardiol J 2012; 19, 5: 466-469)

Abstract


Background: Helicobacter pylori (H.pylori) has been implicated in the pathogenesis of several diseases such as cardiac syndrome X (CSX), which includes chest pain, positive exercise stress test and normal angiography. Also, elevation of homocysteine (Hcy) level is associated with CSX, as it can severely disturb vascular endothelial function. We aimed to elucidate whether the infection of H.pylori affect the level of Hcy in CSX.
Methods: Eighty-eight patients with CSX (32 men, 56 women; mean age: 53.8 ± 11.9) and 97 healthy controls (36 men, 61 women; mean age: 45.7 ± 7.3) were enrolled. Plasma samples were tested for the presence of IgG antibody to H.pylori using enzyme linked immunosorbent assay method. Hcy levels were measured enzymatically.
Results: Plasma Hcy concentration in CSX patients is higher than control group (13.1 ± 2.6 vs. 11.8 ± 2.5 mmol/L; p = 0.002). There was no significant difference between Hcy in H.pylori+ and H.pylori individuals in CSX group (13.1 ± 2.7 vs. 12.2 ± 0.6 mmol/L; p = 0.554) and between two groups in controls, respectively (12.1 ± 2.2 vs. 11.4 ± 2.9 mmol/L; p = 0.148).
Conclusions: Although there is Hcy level increase in H.pylori+ CSX patients and controls comparing to H.pylori subjects, but other factors may affect on Hcy level, too. (Cardiol J 2012; 19, 5: 466-469)
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Keywords

cardiac syndrome X; Helicobacter pylori; homocysteine

About this article
Title

Lack of significant association between Helicobacter pylori infection and homocysteine levels in patients with cardiac syndrome X

Journal

Cardiology Journal

Issue

Vol 19, No 5 (2012)

Pages

466-469

Published online

2012-10-06

DOI

10.5603/CJ.2012.0086

Bibliographic record

Cardiol J 2012;19(5):466-469.

Keywords

cardiac syndrome X
Helicobacter pylori
homocysteine

Authors

Yousef Rasmi
Kamal Mehraban
Masoud Sadreddini
Javad Zeynalzadeh
Maryam Majidinia
MirHossein Seyyed-Mohammadzad
Homayoon Babazadeh

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