Vol 19, No 5 (2012)
Review Article
Published online: 2012-10-06

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5-fluorouracil induced cardiotoxicity: Review of the literature

Michael F. Sorrentino, Jiwon Kim, Andrew E. Foderaro, Alexander G. Truesdell
DOI: 10.5603/CJ.2012.0084
Cardiol J 2012;19(5):453-457.

Abstract

5-fluorouracil (5-FU) is a key chemotherapeutic agent in the treatment of many gastrointestinal tract adenocarcinomas. Despite its proven therapeutic efficacy, 5-FU also possesses several undesired cardiac toxicities, including coronary vasospasm, coronary thrombosis, cardiomyopathy, and sudden cardiac death. This review addresses the incidence, mechanisms of action, clinical presentation, risk stratification, and management of 5-FU associated cardiotoxicity; it also highlights the importance of careful pre-administration cardiac risk stratification and close monitoring during and after drug administration. (Cardiol J 2012; 19, 5: 453-458)

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