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open access

Vol 19, No 5 (2012)
Review Article
Submitted: 2013-01-24
Published online: 2012-10-06
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5-fluorouracil induced cardiotoxicity: Review of the literature

Michael F. Sorrentino, Jiwon Kim, Andrew E. Foderaro, Alexander G. Truesdell
DOI: 10.5603/CJ.2012.0084
·
Cardiol J 2012;19(5):453-457.

open access

Vol 19, No 5 (2012)
Review articles
Submitted: 2013-01-24
Published online: 2012-10-06

Abstract

5-fluorouracil (5-FU) is a key chemotherapeutic agent in the treatment of many gastrointestinal tract adenocarcinomas. Despite its proven therapeutic efficacy, 5-FU also possesses several undesired cardiac toxicities, including coronary vasospasm, coronary thrombosis, cardiomyopathy, and sudden cardiac death. This review addresses the incidence, mechanisms of action, clinical presentation, risk stratification, and management of 5-FU associated cardiotoxicity; it also highlights the importance of careful pre-administration cardiac risk stratification and close monitoring during and after drug administration. (Cardiol J 2012; 19, 5: 453-458)

Abstract

5-fluorouracil (5-FU) is a key chemotherapeutic agent in the treatment of many gastrointestinal tract adenocarcinomas. Despite its proven therapeutic efficacy, 5-FU also possesses several undesired cardiac toxicities, including coronary vasospasm, coronary thrombosis, cardiomyopathy, and sudden cardiac death. This review addresses the incidence, mechanisms of action, clinical presentation, risk stratification, and management of 5-FU associated cardiotoxicity; it also highlights the importance of careful pre-administration cardiac risk stratification and close monitoring during and after drug administration. (Cardiol J 2012; 19, 5: 453-458)

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Keywords

5-fluorouracil; acute coronary syndrome; cardiotoxicity

About this article
Title

5-fluorouracil induced cardiotoxicity: Review of the literature

Journal

Cardiology Journal

Issue

Vol 19, No 5 (2012)

Article type

Review Article

Pages

453-457

Published online

2012-10-06

Page views

3570

Article views/downloads

18531

DOI

10.5603/CJ.2012.0084

Bibliographic record

Cardiol J 2012;19(5):453-457.

Keywords

5-fluorouracil
acute coronary syndrome
cardiotoxicity

Authors

Michael F. Sorrentino
Jiwon Kim
Andrew E. Foderaro
Alexander G. Truesdell

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