open access

Vol 27, No 2 (2023)
Original paper
Published online: 2023-01-11
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Influence of obesity on biological age in patients with arterial hypertension

Olena Kolesnikova1, Olga Zaprovalna1, Tetiana Bondar1, Anna Potapenko1
·
Arterial Hypertension 2023;27(2):88-98.
Affiliations
  1. L.T. Mala Therapy National Institute of the National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine

open access

Vol 27, No 2 (2023)
ORIGINAL PAPERS
Published online: 2023-01-11

Abstract

Background: The aim of this study was to establish the relationship between metabolic disorders, overweight and obesity with markers of accelerated ageing in patients with hypertension.

Materials and methods: One hundred sixteen patients (the age 35–65 years, women 62.3%) with stage 1–2 grade 1–2 hypertension and low/moderate cardiovascular risk (CVR) were included in the study. 34 patients (27.59%) were obese, 50 patients (43.1%) were overweight, 32 patients (29.31%) had normal weight. Anthropometric, clinical, biochemical and molecular genetic methods (relative telomere length (RTL-b), telomerase activity (TA) and 5-methylcytosine global methyl level (GML) in DNA of blood mononuclear cells) were used. Epigenetic age was calculated using the DNAm PhenoAge epigenetic clock.

Results: The increase markers of carbohydrate metabolism [glycated haemoglobin (HbA1c), fasting plasma glucose (FPG), insulin, homeostasis model assessment of insulin resistance (HOMA-IR)], changes of lipid metabolism indicators [an increase in triglycerides (TG) and a decrease in high-density lipoprotein cholesterol (HDL)] were revealed in the obese group, compared with the normal weight group (p < 0.05). We didn’t find differences in RTL-b in any groups (p > 0.05). But at the same time obese patients had higher GML and lower TA (p < 0.05). The accelerated ageing (by DNAm PhenoAge epigenetic clock) was association with higher visceral fat%, higher levels, TG, very low-density lipoprotein cholesterol, all parameters of carbohydrate metabolism (HbA1c, FPG, Insulin, HOMA-IR) and lower HDL-C (p < 0.05).

Conclusions: Pathological weight gain associated with the progression of metabolic disorders and accelerated ageing
in patients with hypertension and low/moderate cardiovascular risk.

Abstract

Background: The aim of this study was to establish the relationship between metabolic disorders, overweight and obesity with markers of accelerated ageing in patients with hypertension.

Materials and methods: One hundred sixteen patients (the age 35–65 years, women 62.3%) with stage 1–2 grade 1–2 hypertension and low/moderate cardiovascular risk (CVR) were included in the study. 34 patients (27.59%) were obese, 50 patients (43.1%) were overweight, 32 patients (29.31%) had normal weight. Anthropometric, clinical, biochemical and molecular genetic methods (relative telomere length (RTL-b), telomerase activity (TA) and 5-methylcytosine global methyl level (GML) in DNA of blood mononuclear cells) were used. Epigenetic age was calculated using the DNAm PhenoAge epigenetic clock.

Results: The increase markers of carbohydrate metabolism [glycated haemoglobin (HbA1c), fasting plasma glucose (FPG), insulin, homeostasis model assessment of insulin resistance (HOMA-IR)], changes of lipid metabolism indicators [an increase in triglycerides (TG) and a decrease in high-density lipoprotein cholesterol (HDL)] were revealed in the obese group, compared with the normal weight group (p < 0.05). We didn’t find differences in RTL-b in any groups (p > 0.05). But at the same time obese patients had higher GML and lower TA (p < 0.05). The accelerated ageing (by DNAm PhenoAge epigenetic clock) was association with higher visceral fat%, higher levels, TG, very low-density lipoprotein cholesterol, all parameters of carbohydrate metabolism (HbA1c, FPG, Insulin, HOMA-IR) and lower HDL-C (p < 0.05).

Conclusions: Pathological weight gain associated with the progression of metabolic disorders and accelerated ageing
in patients with hypertension and low/moderate cardiovascular risk.

Get Citation

Keywords

overweight; obesity; arterial hypertension; epigenetic age; accelerated ageing

About this article
Title

Influence of obesity on biological age in patients with arterial hypertension

Journal

Arterial Hypertension

Issue

Vol 27, No 2 (2023)

Article type

Original paper

Pages

88-98

Published online

2023-01-11

Page views

1688

Article views/downloads

291

DOI

10.5603/AH.a2023.0001

Bibliographic record

Arterial Hypertension 2023;27(2):88-98.

Keywords

overweight
obesity
arterial hypertension
epigenetic age
accelerated ageing

Authors

Olena Kolesnikova
Olga Zaprovalna
Tetiana Bondar
Anna Potapenko

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