open access
Influence of obesity on biological age in patients with arterial hypertension
- L.T. Mala Therapy National Institute of the National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine
open access
Abstract
Background: The aim of this study was to establish the relationship between metabolic disorders, overweight and obesity with markers of accelerated ageing in patients with hypertension.
Materials and methods: One hundred sixteen patients (the age 35–65 years, women 62.3%) with stage 1–2 grade 1–2 hypertension and low/moderate cardiovascular risk (CVR) were included in the study. 34 patients (27.59%) were obese, 50 patients (43.1%) were overweight, 32 patients (29.31%) had normal weight. Anthropometric, clinical, biochemical and molecular genetic methods (relative telomere length (RTL-b), telomerase activity (TA) and 5-methylcytosine global methyl level (GML) in DNA of blood mononuclear cells) were used. Epigenetic age was calculated using the DNAm PhenoAge epigenetic clock.
Results: The increase markers of carbohydrate metabolism [glycated haemoglobin (HbA1c), fasting plasma glucose (FPG), insulin, homeostasis model assessment of insulin resistance (HOMA-IR)], changes of lipid metabolism indicators [an increase in triglycerides (TG) and a decrease in high-density lipoprotein cholesterol (HDL)] were revealed in the obese group, compared with the normal weight group (p < 0.05). We didn’t find differences in RTL-b in any groups (p > 0.05). But at the same time obese patients had higher GML and lower TA (p < 0.05). The accelerated ageing (by DNAm PhenoAge epigenetic clock) was association with higher visceral fat%, higher levels, TG, very low-density lipoprotein cholesterol, all parameters of carbohydrate metabolism (HbA1c, FPG, Insulin, HOMA-IR) and lower HDL-C (p < 0.05).
Conclusions: Pathological weight gain associated with the progression of metabolic disorders and accelerated ageing
in patients with hypertension and low/moderate cardiovascular risk.
Abstract
Background: The aim of this study was to establish the relationship between metabolic disorders, overweight and obesity with markers of accelerated ageing in patients with hypertension.
Materials and methods: One hundred sixteen patients (the age 35–65 years, women 62.3%) with stage 1–2 grade 1–2 hypertension and low/moderate cardiovascular risk (CVR) were included in the study. 34 patients (27.59%) were obese, 50 patients (43.1%) were overweight, 32 patients (29.31%) had normal weight. Anthropometric, clinical, biochemical and molecular genetic methods (relative telomere length (RTL-b), telomerase activity (TA) and 5-methylcytosine global methyl level (GML) in DNA of blood mononuclear cells) were used. Epigenetic age was calculated using the DNAm PhenoAge epigenetic clock.
Results: The increase markers of carbohydrate metabolism [glycated haemoglobin (HbA1c), fasting plasma glucose (FPG), insulin, homeostasis model assessment of insulin resistance (HOMA-IR)], changes of lipid metabolism indicators [an increase in triglycerides (TG) and a decrease in high-density lipoprotein cholesterol (HDL)] were revealed in the obese group, compared with the normal weight group (p < 0.05). We didn’t find differences in RTL-b in any groups (p > 0.05). But at the same time obese patients had higher GML and lower TA (p < 0.05). The accelerated ageing (by DNAm PhenoAge epigenetic clock) was association with higher visceral fat%, higher levels, TG, very low-density lipoprotein cholesterol, all parameters of carbohydrate metabolism (HbA1c, FPG, Insulin, HOMA-IR) and lower HDL-C (p < 0.05).
Conclusions: Pathological weight gain associated with the progression of metabolic disorders and accelerated ageing
in patients with hypertension and low/moderate cardiovascular risk.
Keywords
overweight; obesity; arterial hypertension; epigenetic age; accelerated ageing
Title
Influence of obesity on biological age in patients with arterial hypertension
Journal
Issue
Article type
Original paper
Pages
88-98
Published online
2023-01-11
Page views
1688
Article views/downloads
291
DOI
Bibliographic record
Arterial Hypertension 2023;27(2):88-98.
Keywords
overweight
obesity
arterial hypertension
epigenetic age
accelerated ageing
Authors
Olena Kolesnikova
Olga Zaprovalna
Tetiana Bondar
Anna Potapenko
- Obesity and overweight. https://www.who.int/en/news-room/fact-sheets/detail/obesity-and-overweight (Accessed 22/11 2019).
- Bays HE, McCarthy W, Burridge K et al, Obesity Algorithm eBook, presented by the Obesity Medicine Association. www.obesityalgorithm.org. 2021. https://obesitymedicine.org/obesity-algorithm/.
- Ageing and health. World Health Organization, 05 Feb 2018. https://www.who.int/news-room/fact-sheets/detail/ageing-and-health..
- Aging Well in the 21st Century: Strategic Directions for Research on Aging. NIA Strategic Directions, 2016, 35 pp. https://www.nia.nih.gov/sites/default/files/2017-07/nia-strategic-directions-2016.pdf..
- Santos AL, Sinha S. Obesity and aging: Molecular mechanisms and therapeutic approaches. Ageing Res Rev. 2021; 67: 101268.
- Assmann KE, Ruhunuhewa I, Adjibade M, et al. The Mediating Role of Overweight and Obesity in the Prospective Association between Overall Dietary Quality and Healthy Aging. Nutrients. 2018; 10(4).
- Lin YH, Chiou JM, Chen TF, et al. The association between metabolic syndrome and successful aging- using an extended definition of successful aging. PLoS One. 2021; 16(11): e0260550.
- National Health and Nutrition Examination Survey 2017–March 2020 Prepandemic Data Files Development of Files and Prevalence Estimates for Selected Health Outcomes: National Center for Health Statistics (U.S.) NHSR National Health Statistics Reports URL No. 158. 2021 14 Jun. https://stacks.cdc.gov/view/cdc/106273.
- Csige I, Ujvárosy D, Szabó Z, et al. The Impact of Obesity on the Cardiovascular System. J Diabetes Res. 2018; 2018: 3407306.
- Riaz H, Khan MS, Siddiqi TJ, et al. Association Between Obesity and Cardiovascular Outcomes: A Systematic Review and Meta-analysis of Mendelian Randomization Studies. JAMA Netw Open. 2018; 1(7): e183788.
- Diebel LWM, Rockwood K. Determination of Biological Age: Geriatric Assessment vs Biological Biomarkers. Curr Oncol Rep. 2021; 23(9): 104.
- Guerville F, De Souto Barreto P, Ader I, et al. Revisiting the Hallmarks of Aging to Identify Markers of Biological Age. J Prev Alzheimers Dis. 2020; 7(1): 56–64.
- Belsky DW, Moffitt TE, Cohen AA, et al. Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing? Am J Epidemiol. 2018; 187(6): 1220–1230.
- Jansen R, Han LKm, Verhoeven JE, et al. An integrative study of five biological clocks in somatic and mental health. Elife. 2021; 10.
- Yeh JK, Lin MH, Wang CY. Telomeres as Therapeutic Targets in Heart Disease. JACC Basic Transl Sci. 2019; 4(7): 855–865.
- Schellnegger M, Lin AC, Hammer N, et al. Physical Activity on Telomere Length as a Biomarker for Aging: A Systematic Review. Sports Med Open. 2022; 8(1): 111.
- Amano H, Chaudhury A, Rodriguez-Aguayo C, et al. Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease. Cell Metab. 2019; 29(6): 1274–1290.e9.
- Cheng F, Carroll L, Joglekar M, et al. Diabetes, metabolic disease, and telomere length. Lancet Diabetes Endocrinol. 2021; 9(2): 117–126.
- Verma AK, Singh P, Al-Saeed FA, et al. Unravelling the role of telomere shortening with ageing and their potential association with diabetes, cancer, and related lifestyle factors. Tissue Cell. 2022; 79: 101925.
- Zhou Y, Hambly BD, McLachlan CS. FTO associations with obesity and telomere length. J Biomed Sci. 2017; 24(1): 65.
- Peña E, León-Mengíbar J, Powell TR, et al. Telomere length in patients with obesity submitted to bariatric surgery: A systematic review. Eur Eat Disord Rev. 2021; 29(6): 842–853.
- Welendorf C, Nicoletti CF, Pinhel MA, et al. Obesity, weight loss, and influence on telomere length: New insights for personalized nutrition. Nutrition. 2019; 66: 115–121.
- Field AE, Robertson NA, Wang T, et al. DNA Methylation Clocks in Aging: Categories, Causes, and Consequences. Mol Cell. 2018; 71(6): 882–895.
- Horvath S, Pirazzini C, Bacalini MG, et al. Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring. Aging (Albany NY). 2015; 7(12): 1159–1170.
- Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013; 14(10): R115.
- Quach A, Levine ME, Tanaka T, et al. Epigenetic clock analysis of diet, exercise, education, and lifestyle factors. Aging (Albany NY). 2017; 9(2): 419–446.
- Salameh Y, Bejaoui Y, El Hajj N. DNA Methylation Biomarkers in Aging and Age-Related Diseases. Front Genet. 2020; 11: 171.
- Salvestrini V, Sell C, Lorenzini A. Obesity May Accelerate the Aging Process. Front Endocrinol (Lausanne). 2019; 10: 266.
- Zgheib NK, Sleiman F, Nasreddine L, et al. Short Telomere Length is Associated with Aging, Central Obesity, Poor Sleep and Hypertension in Lebanese Individuals. Aging Dis. 2018; 9(1): 77–89.
- Kolesnikova O, Potapenko A, Vysotska O, et al. Evaluation of hormonal and metabolic parameters, along with cardiovascular risk factors in women with non-alcoholic fatty liver disease combined with subclinical hypothyroidism depending on age. EUREKA: Health Sciences. 2021(1): 48–57.
- Shalimova A, Psarova V, Kochuieva M, et al. Features of hemodynamic and metabolic disorders in obese patients with resistant hypertension. Arterial Hypertens. 2020; 24(1): 22–29.
- Conte M, Martucci M, Sandri M, et al. The Dual Role of the Pervasive "Fattish" Tissue Remodeling With Age. Front Endocrinol (Lausanne). 2019; 10: 114.
- Salmon AB. Beyond Diabetes: Does Obesity-Induced Oxidative Stress Drive the Aging Process? Antioxidants (Basel). 2016; 5(3).
- Zhang Y, Fischer KE, Soto V, et al. Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice. Arch Biochem Biophys. 2015; 576: 39–48.
- Balayah Z, Alsheikh-Ali AA, Rashed W, et al. Association of obesity indices with in-hospital and 1-year mortality following acute coronary syndrome. Int J Obes (Lond). 2021; 45(2): 358–368.
- Grover SA, Kaouache M, Rempel P, et al. Years of life lost and healthy life-years lost from diabetes and cardiovascular disease in overweight and obese people: a modelling study. Lancet Diabetes Endocrinol. 2015; 3(2): 114–122.
- Rodríguez-González GL, Reyes-Castro LA, Bautista CJ, et al. Maternal obesity accelerates rat offspring metabolic ageing in a sex-dependent manner. J Physiol. 2019; 597(23): 5549–5563.
- Stout MB, Justice JN, Nicklas BJ, et al. Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty. Physiology (Bethesda). 2017; 32(1): 9–19.
- Phillips MCl. Metabolic Strategies in Healthcare: A New Era. Aging Dis. 2022; 13(3): 655–672.