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Serum amphiregulin and cerebellin 1 levels in primary hypertension patients
, 1, 2, 3, 4
Affiliations- Department of Emergency Medicine, Kahramanmaraş Sütçü İmam University School of Medicine, Kahramanmaraş, Türkiye
- Department of Cardiology, Kahramanmaraş Necip Fazıl State Hospital, Kahramanmaraş, Turkey
- Department of Biochemistry, Kahramanmaraş Sütçü İmam University School of Medicine, Kahramanmaraş, Turkey
- Department of Cardiology, Kahramanmaraş Sütçü İmam University School of Medicine, Kahramanmaraş, Turkey
open access
Abstract
Background: Hypertension is a major risk factor for cardiovascular diseases, stroke, congestive heart disease and renal failure. Primary hypertension is a multi-factorial complex disease and its exact etiology still remains unknown. In this study we aimed to compare serum amphiregulin and cerebellin-1 levels of primary hypertension patients with healthy subjects.
Material and methods: Forty-four hypertensive patients and 44 healthy people were included. Patients with systolic blood pressure measurements ≥ 140 mm Hg and diastolic blood pressure measurements ≥ 90 mm Hg were evaluated as hypertensive. Serum amphiregulin and cerebellin 1 levels were measured using ELISA method.
Results: Mean amphiregulin level was 32.1 (10.2–72.5) pg/mL in hypertension group and 36.9 (15.9–109.5) pg/mL in control group (p = 0.002). Mean cerebellin 1 levels were comparable in both groups, 82.1 (23.9–286.1) pg/mL in hypertensive group and 95.1 (60.2–293) pg/mL in control group (p = 0.261). Serum amphiregulin to predict hypertension was found to be ≤ 23 pg/mL with specificity of 97% and sensitivity of 48.5% (AUC = 0.74; 95% CI, 0.62–0.86; p = 0.001).
Conclusions: Hypertension is associated with lower serum amphiregulin concentrations.
Abstract
Background: Hypertension is a major risk factor for cardiovascular diseases, stroke, congestive heart disease and renal failure. Primary hypertension is a multi-factorial complex disease and its exact etiology still remains unknown. In this study we aimed to compare serum amphiregulin and cerebellin-1 levels of primary hypertension patients with healthy subjects.
Material and methods: Forty-four hypertensive patients and 44 healthy people were included. Patients with systolic blood pressure measurements ≥ 140 mm Hg and diastolic blood pressure measurements ≥ 90 mm Hg were evaluated as hypertensive. Serum amphiregulin and cerebellin 1 levels were measured using ELISA method.
Results: Mean amphiregulin level was 32.1 (10.2–72.5) pg/mL in hypertension group and 36.9 (15.9–109.5) pg/mL in control group (p = 0.002). Mean cerebellin 1 levels were comparable in both groups, 82.1 (23.9–286.1) pg/mL in hypertensive group and 95.1 (60.2–293) pg/mL in control group (p = 0.261). Serum amphiregulin to predict hypertension was found to be ≤ 23 pg/mL with specificity of 97% and sensitivity of 48.5% (AUC = 0.74; 95% CI, 0.62–0.86; p = 0.001).
Conclusions: Hypertension is associated with lower serum amphiregulin concentrations.
Keywords
amphiregulin; cerebellin 1; primary hypertension; ELISA
About this articleTitle
Serum amphiregulin and cerebellin 1 levels in primary hypertension patients
Journal
Issue
Article type
Original paper
Pages
120-127
Published online
2020-09-16
Page views
735
Article views/downloads
597
DOI
Bibliographic record
Arterial Hypertension 2020;24(3):120-127.
Keywords
amphiregulin
cerebellin 1
primary hypertension
ELISA
Authors
Özlem Güler
Hakan Hakkoymaz
Sedat Köroğlu
Muhammed Seyithanoğlu
Hakan Güneş
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