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Vol 22, No 3 (2018)
Original paper
Published online: 2018-09-28
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Vitamin D in children with primary hypertension

Piotr Skrzypczyk1, Anna Ofiara1, Michał Szyszka2, Katarzyna Dziedzic-Jankowska1, Jarosław Sołtyski1, Małgorzata Pańczyk-Tomaszewska1
DOI: 10.5603/AH.2018.0015
·
Arterial Hypertension 2018;22(3):127-134.
Affiliations
  1. Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland
  2. Student Scientific Group at the Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland

open access

Vol 22, No 3 (2018)
ORIGINAL PAPERS
Published online: 2018-09-28

Abstract

Introduction: Recent evidence suggests that vitamin D plays a role in pathogenesis of arterial hypertension. The aim was to assess vitamin D in children and adolescents with arterial hypertension.

Material and methods: In 49 children (14.29 ± 3.17 years) with arterial hypertension we evaluated vitamin D status (according to Polish 2018 Guidelines), serum calcium, phosphorus, parathormone, alkaline phosphatase, office blood pressure, ABPM (including ambulatory arterial stiffness index [AASI]), BMI, GFR, uric acid, lipids and albuminuria. None of the children were supplemented with vitamin D.

Results: Mean vitamin D concentration was 19.74 ± 9.68 ng/mL. Vitamin D severe deficiency (0–10 ng/mL) was found in 5 (10.2%), deficiency (> 10–20 ng/mL) in 29 (49.0%), suboptimal concentration (> 20–30 ng/mL) in 17 (34.7%), optimal concentration (> 30 to 50 ng/mL) in 1 (2.0%), and high concentration (> 50 to 100 ng/mL) in 2 (4.1%) children. Vitamin D was higher in spring-summer vs. autumn-winter (21.79 ± 10.19 vs. 15.53 ± 7.08 ng/mL, p = 0.03). Vitamin D correlated with height Z-score (r = 0.39, p < 0.01), BMI Z-score (r = -0.34, p = 0.02), uric acid (r = -0.31, p = 0.04), triglycerides (r = -0.37, p = 0.01), but not with office blood pressure and ABPM parameters except for heart rate (r = -0.38, p < 0.01). In 24 children treated with antihypertensive medications vitamin D correlated with AASI (r = 0.50, p = 0.04).

Conclusions:

  1. Inadequate vitamin D supply is ubiquitous in children with arterial hypertension.
  2. Vitamin D deficiency should be suspected especially in autumn-winter period and among obese and short children.
  3. The relation between vitamin D status and ambulatory arterial stiffness index suggests negative influence of vitamin D on arterial wall but requires further investigations.

Abstract

Introduction: Recent evidence suggests that vitamin D plays a role in pathogenesis of arterial hypertension. The aim was to assess vitamin D in children and adolescents with arterial hypertension.

Material and methods: In 49 children (14.29 ± 3.17 years) with arterial hypertension we evaluated vitamin D status (according to Polish 2018 Guidelines), serum calcium, phosphorus, parathormone, alkaline phosphatase, office blood pressure, ABPM (including ambulatory arterial stiffness index [AASI]), BMI, GFR, uric acid, lipids and albuminuria. None of the children were supplemented with vitamin D.

Results: Mean vitamin D concentration was 19.74 ± 9.68 ng/mL. Vitamin D severe deficiency (0–10 ng/mL) was found in 5 (10.2%), deficiency (> 10–20 ng/mL) in 29 (49.0%), suboptimal concentration (> 20–30 ng/mL) in 17 (34.7%), optimal concentration (> 30 to 50 ng/mL) in 1 (2.0%), and high concentration (> 50 to 100 ng/mL) in 2 (4.1%) children. Vitamin D was higher in spring-summer vs. autumn-winter (21.79 ± 10.19 vs. 15.53 ± 7.08 ng/mL, p = 0.03). Vitamin D correlated with height Z-score (r = 0.39, p < 0.01), BMI Z-score (r = -0.34, p = 0.02), uric acid (r = -0.31, p = 0.04), triglycerides (r = -0.37, p = 0.01), but not with office blood pressure and ABPM parameters except for heart rate (r = -0.38, p < 0.01). In 24 children treated with antihypertensive medications vitamin D correlated with AASI (r = 0.50, p = 0.04).

Conclusions:

  1. Inadequate vitamin D supply is ubiquitous in children with arterial hypertension.
  2. Vitamin D deficiency should be suspected especially in autumn-winter period and among obese and short children.
  3. The relation between vitamin D status and ambulatory arterial stiffness index suggests negative influence of vitamin D on arterial wall but requires further investigations.

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Keywords

children, adolescents, primary hypertension, vitamin D, ambulatory blood pressure monitoring, arterial stiffness

About this article
Title

Vitamin D in children with primary hypertension

Journal

Arterial Hypertension

Issue

Vol 22, No 3 (2018)

Article type

Original paper

Pages

127-134

Published online

2018-09-28

Page views

1358

Article views/downloads

908

DOI

10.5603/AH.2018.0015

Bibliographic record

Arterial Hypertension 2018;22(3):127-134.

Keywords

children
adolescents
primary hypertension
vitamin D
ambulatory blood pressure monitoring
arterial stiffness

Authors

Piotr Skrzypczyk
Anna Ofiara
Michał Szyszka
Katarzyna Dziedzic-Jankowska
Jarosław Sołtyski
Małgorzata Pańczyk-Tomaszewska

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