open access

Vol 4, No 3 (2000)
REVIEV
Published online: 2000-07-20
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The Role of Mineralocorticoid Receptors in Pathogenesis of Hypertension

Zygmunt Zdrojewicz, Aleksandra Sztuka-Pietkiewicz, Wojciech Pietkiewicz
Nadciśnienie tętnicze 2000;4(3):209-216.

open access

Vol 4, No 3 (2000)
REVIEV
Published online: 2000-07-20

Abstract

Mineralocorticoids, among which aldosterone is the most important factor, have great influence on cardio-vascular system: they regulate ion transport in renal distal tubules causing chloride and sodium retention and potassium and hydrogen secretion. They maintain proper blood pressure, have positive inotropic effect and may cause heart-fibrosis. Aldosterone and other mineralocorticoids act through intracellular and membrane receptors (MRs). Thus mineralocorticoids regulate genes’ transciption and have their own intracellular mediators (HSP, calcineurin, cAMP, inositol-1,4,5-trisphosphate). One of the most important factors determining aldosterone selectivity for MRs is the presence of 11-b-hydroxysteroid dehydrogenase (11-b-HSD). It is supposed that some manifestations of arterial blood pressure can be connected with MRs system disturbance and some changes in 11-b-HSD activity. Mediation on the receptor level appears to be very promising way of treatment of many aldosterone-related diseases, that is why a general interest in selective antagonists of MRs lowering the arterial blood pressure is taken.

Abstract

Mineralocorticoids, among which aldosterone is the most important factor, have great influence on cardio-vascular system: they regulate ion transport in renal distal tubules causing chloride and sodium retention and potassium and hydrogen secretion. They maintain proper blood pressure, have positive inotropic effect and may cause heart-fibrosis. Aldosterone and other mineralocorticoids act through intracellular and membrane receptors (MRs). Thus mineralocorticoids regulate genes’ transciption and have their own intracellular mediators (HSP, calcineurin, cAMP, inositol-1,4,5-trisphosphate). One of the most important factors determining aldosterone selectivity for MRs is the presence of 11-b-hydroxysteroid dehydrogenase (11-b-HSD). It is supposed that some manifestations of arterial blood pressure can be connected with MRs system disturbance and some changes in 11-b-HSD activity. Mediation on the receptor level appears to be very promising way of treatment of many aldosterone-related diseases, that is why a general interest in selective antagonists of MRs lowering the arterial blood pressure is taken.
Get Citation

Keywords

: mineralocorticoid receptor; antagonist; of 11-b-hydroxysteroid dehydrogenase; calcineurin; carbe-noxolone; canrenoate

About this article
Title

The Role of Mineralocorticoid Receptors in Pathogenesis of Hypertension

Journal

Arterial Hypertension

Issue

Vol 4, No 3 (2000)

Pages

209-216

Published online

2000-07-20

Bibliographic record

Nadciśnienie tętnicze 2000;4(3):209-216.

Keywords

: mineralocorticoid receptor
antagonist
of 11-b-hydroxysteroid dehydrogenase
calcineurin
carbe-noxolone
canrenoate

Authors

Zygmunt Zdrojewicz
Aleksandra Sztuka-Pietkiewicz
Wojciech Pietkiewicz

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