open access

Vol 6, No 1 (2002)
Prace oryginalne
Published online: 2001-12-31
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The Association between Ambulatory Blood Pressure and Fasting Insulin and Glucose Plasma Levels in Normotensive Premenopausal Women

Andrzej Płoszyński, Wojciech Sobiczewski, Elżbieta Kusiak, Bartosz Curyłło, Andrzej Koprowski, Marcin Fijałkowski, Czesław Wójcikowski, Jerzy Mielnik, Andrzej Rynkiewicz
Nadciśnienie tętnicze 2002;6(1):35-44.

open access

Vol 6, No 1 (2002)
Prace oryginalne
Published online: 2001-12-31

Abstract

Background Elevated plasma glucose and insulin levels are associated with increased risk of hypertension and coronary heart disease. However there are very few reports on the relation between fasting insulin and glucose and blood pressure profile in normotensive premenopausal women. The aim of our study was to assess the influence of fasting plasma glucose and insulin level on 24-h systolic (SBP) and diastolic (DBP) blood pressure in normotensive premenopausal women.
Material and methods The study was performed in 88 premenopausal women, mean age 46 ± 4 years (22 women with normal hormone profile, 33 women with hiperandrogenism and 33 women with disturbed estrogen secretion). Mean 24 hour, day and night blood pressure and heart rate recorded by Spacelabs 90207 were analysed.
Results There was a significant correlation between fasting serum insulin level and 24-h SBP (r = 0,41, p < 0,001) and 24-h DBP (r = 0,33, p < 0,002). Fasting plasma glucose significantly correlated with 24-h SBP (r = 0,28, p < 0,01) but not with 24-h DBP. Similarly fasting insulin correlated significantly with day and night SBP (r = 0,36, p < 0,001 and r = 0,42, p < 0,001 respectively). Fasting insulin correlated significantly with day and night DBP (r = 0,28, p < 0,01 and r = 0,32, p < 0,002 respectively).
In the study group we observed significant correlation between mean night heart rate and fasting plasma glucose and insulin (r = 0,29, p < 0,005 and r = 0,37, p < 0,001 respectively).
Conclusions Our study revealed that fasting insulin level is significantly related to 24-h, day and night systolic and diastolic blood pressure in normotensive premenopausal women.

Abstract

Background Elevated plasma glucose and insulin levels are associated with increased risk of hypertension and coronary heart disease. However there are very few reports on the relation between fasting insulin and glucose and blood pressure profile in normotensive premenopausal women. The aim of our study was to assess the influence of fasting plasma glucose and insulin level on 24-h systolic (SBP) and diastolic (DBP) blood pressure in normotensive premenopausal women.
Material and methods The study was performed in 88 premenopausal women, mean age 46 ± 4 years (22 women with normal hormone profile, 33 women with hiperandrogenism and 33 women with disturbed estrogen secretion). Mean 24 hour, day and night blood pressure and heart rate recorded by Spacelabs 90207 were analysed.
Results There was a significant correlation between fasting serum insulin level and 24-h SBP (r = 0,41, p < 0,001) and 24-h DBP (r = 0,33, p < 0,002). Fasting plasma glucose significantly correlated with 24-h SBP (r = 0,28, p < 0,01) but not with 24-h DBP. Similarly fasting insulin correlated significantly with day and night SBP (r = 0,36, p < 0,001 and r = 0,42, p < 0,001 respectively). Fasting insulin correlated significantly with day and night DBP (r = 0,28, p < 0,01 and r = 0,32, p < 0,002 respectively).
In the study group we observed significant correlation between mean night heart rate and fasting plasma glucose and insulin (r = 0,29, p < 0,005 and r = 0,37, p < 0,001 respectively).
Conclusions Our study revealed that fasting insulin level is significantly related to 24-h, day and night systolic and diastolic blood pressure in normotensive premenopausal women.
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Keywords

blood pressure; hypertension; fasting insulin; fasting glucose level; hyperinsulinemia; insulin resistance; hyperandrogenism

About this article
Title

The Association between Ambulatory Blood Pressure and Fasting Insulin and Glucose Plasma Levels in Normotensive Premenopausal Women

Journal

Arterial Hypertension

Issue

Vol 6, No 1 (2002)

Pages

35-44

Published online

2001-12-31

Bibliographic record

Nadciśnienie tętnicze 2002;6(1):35-44.

Keywords

blood pressure
hypertension
fasting insulin
fasting glucose level
hyperinsulinemia
insulin resistance
hyperandrogenism

Authors

Andrzej Płoszyński
Wojciech Sobiczewski
Elżbieta Kusiak
Bartosz Curyłło
Andrzej Koprowski
Marcin Fijałkowski
Czesław Wójcikowski
Jerzy Mielnik
Andrzej Rynkiewicz

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