open access

Vol 7, No 1 (2003)
Prace oryginalne
Published online: 2003-01-16
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Blood Pressure Decrease Analysis After the First Dose of Perindopril or Trandolapril in Acute Myocardial Infarction Patients

Wojciech Sobiczewski, Marcin Gruchała, Rafał Dworakowski, Andrzej Koprowski, Adam Grzybowski, Andrzej Rynkiewicz
Nadciśnienie tętnicze 2003;7(1):27-33.

open access

Vol 7, No 1 (2003)
Prace oryginalne
Published online: 2003-01-16

Abstract

Background Angiotensin converting enzyme inhibitors became very important therapeutic agents in the treatment of cardiovascular diseases in the recent years. Several clinical trials confirmed significant benefits of the early use of ACE inhibitors in acute myocardial infarction patients. However reasonable is apprehension for potential risk of the first dose hypotension specially in selected groups of high risk patients.
The objective of this study was to evaluate decrease of systolic and diastolic blood pressure in the analysis of mean difference between subsequent mean one hour blood pressure and initial one hour blood pressure in control group and group treated with perindopril or trandolapril.
Material and methods Study was conducted in 107 acute myocardial infarction patients, control group consisted of 40 patients, 32 were treated with perindopril and 35 with trandolapril. 24-hour blood pressure monitoring was performed in the 1, 2 or 3rd day of the acute myocardial infarction.
Results Despite significant systolic blood pressure decrease after the first dose of ACE inhibitor we have not observed excessive hypotensive reaction in studied groups. Mean maximal systolic blood pressure decrease and frequency of hypotensive effect exceeding 20 mm Hg in treated groups was similar in comparison to control group.
We have perceived greater hypotensive effect after the first dose of perindopril on systolic blood pressure and trandolapril on diastolic blood pressure in studied groups.
Conclusion There was no significant differences in mean maximal blood pressure decrease after the first dose of perindopril or trandolapril in acute myocardial infarction patients.

Abstract

Background Angiotensin converting enzyme inhibitors became very important therapeutic agents in the treatment of cardiovascular diseases in the recent years. Several clinical trials confirmed significant benefits of the early use of ACE inhibitors in acute myocardial infarction patients. However reasonable is apprehension for potential risk of the first dose hypotension specially in selected groups of high risk patients.
The objective of this study was to evaluate decrease of systolic and diastolic blood pressure in the analysis of mean difference between subsequent mean one hour blood pressure and initial one hour blood pressure in control group and group treated with perindopril or trandolapril.
Material and methods Study was conducted in 107 acute myocardial infarction patients, control group consisted of 40 patients, 32 were treated with perindopril and 35 with trandolapril. 24-hour blood pressure monitoring was performed in the 1, 2 or 3rd day of the acute myocardial infarction.
Results Despite significant systolic blood pressure decrease after the first dose of ACE inhibitor we have not observed excessive hypotensive reaction in studied groups. Mean maximal systolic blood pressure decrease and frequency of hypotensive effect exceeding 20 mm Hg in treated groups was similar in comparison to control group.
We have perceived greater hypotensive effect after the first dose of perindopril on systolic blood pressure and trandolapril on diastolic blood pressure in studied groups.
Conclusion There was no significant differences in mean maximal blood pressure decrease after the first dose of perindopril or trandolapril in acute myocardial infarction patients.
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Keywords

acute myocardial infarction; 24-hour blood pressure monitoring; perindopril; trandolapril

About this article
Title

Blood Pressure Decrease Analysis After the First Dose of Perindopril or Trandolapril in Acute Myocardial Infarction Patients

Journal

Arterial Hypertension

Issue

Vol 7, No 1 (2003)

Pages

27-33

Published online

2003-01-16

Bibliographic record

Nadciśnienie tętnicze 2003;7(1):27-33.

Keywords

acute myocardial infarction
24-hour blood pressure monitoring
perindopril
trandolapril

Authors

Wojciech Sobiczewski
Marcin Gruchała
Rafał Dworakowski
Andrzej Koprowski
Adam Grzybowski
Andrzej Rynkiewicz

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