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Blood Pressure Decrease Analysis After the First Dose of Perindopril or Trandolapril in Acute Myocardial Infarction Patients
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Abstract
The objective of this study was to evaluate decrease of systolic and diastolic blood pressure in the analysis of mean difference between subsequent mean one hour blood pressure and initial one hour blood pressure in control group and group treated with perindopril or trandolapril.
Material and methods Study was conducted in 107 acute myocardial infarction patients, control group consisted of 40 patients, 32 were treated with perindopril and 35 with trandolapril. 24-hour blood pressure monitoring was performed in the 1, 2 or 3rd day of the acute myocardial infarction.
Results Despite significant systolic blood pressure decrease after the first dose of ACE inhibitor we have not observed excessive hypotensive reaction in studied groups. Mean maximal systolic blood pressure decrease and frequency of hypotensive effect exceeding 20 mm Hg in treated groups was similar in comparison to control group.
We have perceived greater hypotensive effect after the first dose of perindopril on systolic blood pressure and trandolapril on diastolic blood pressure in studied groups.
Conclusion There was no significant differences in mean maximal blood pressure decrease after the first dose of perindopril or trandolapril in acute myocardial infarction patients.
Abstract
The objective of this study was to evaluate decrease of systolic and diastolic blood pressure in the analysis of mean difference between subsequent mean one hour blood pressure and initial one hour blood pressure in control group and group treated with perindopril or trandolapril.
Material and methods Study was conducted in 107 acute myocardial infarction patients, control group consisted of 40 patients, 32 were treated with perindopril and 35 with trandolapril. 24-hour blood pressure monitoring was performed in the 1, 2 or 3rd day of the acute myocardial infarction.
Results Despite significant systolic blood pressure decrease after the first dose of ACE inhibitor we have not observed excessive hypotensive reaction in studied groups. Mean maximal systolic blood pressure decrease and frequency of hypotensive effect exceeding 20 mm Hg in treated groups was similar in comparison to control group.
We have perceived greater hypotensive effect after the first dose of perindopril on systolic blood pressure and trandolapril on diastolic blood pressure in studied groups.
Conclusion There was no significant differences in mean maximal blood pressure decrease after the first dose of perindopril or trandolapril in acute myocardial infarction patients.
Keywords
acute myocardial infarction; 24-hour blood pressure monitoring; perindopril; trandolapril
Title
Blood Pressure Decrease Analysis After the First Dose of Perindopril or Trandolapril in Acute Myocardial Infarction Patients
Journal
Issue
Article type
Original paper
Pages
27-33
Published online
2003-01-16
Page views
577
Article views/downloads
1122
Bibliographic record
Nadciśnienie tętnicze 2003;7(1):27-33.
Keywords
acute myocardial infarction
24-hour blood pressure monitoring
perindopril
trandolapril
Authors
Wojciech Sobiczewski
Marcin Gruchała
Rafał Dworakowski
Andrzej Koprowski
Adam Grzybowski
Andrzej Rynkiewicz